4GYY

Crystal structure of human O-GlcNAc Transferase with UDP-5SGlcNAc and a peptide substrate

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	TPR_11_1	e4gyyA7	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_1	ECOD (1.6)
A	Glyco_transf_41_2nd	e4gyyA5	A: a+b complex topology	X: Insertion domain in O-GlcNAc transferase (From Topology)	H: Insertion domain in O-GlcNAc transferase (From Topology)	T: Insertion domain in O-GlcNAc transferase	F: Glyco_transf_41_2nd	ECOD (1.6)
A	Glyco_transf_41_1st	e4gyyA8	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_41_1st	ECOD (1.6)
A	Glyco_transf_41_3rd	e4gyyA4	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_41_3rd	ECOD (1.6)
C	TPR_11_1	e4gyyC20	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_11_1	ECOD (1.6)
C	Glyco_transf_41_2nd	e4gyyC19	A: a+b complex topology	X: Insertion domain in O-GlcNAc transferase (From Topology)	H: Insertion domain in O-GlcNAc transferase (From Topology)	T: Insertion domain in O-GlcNAc transferase	F: Glyco_transf_41_2nd	ECOD (1.6)
C	Glyco_transf_41_1st	e4gyyC18	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_41_1st	ECOD (1.6)
C	Glyco_transf_41_3rd	e4gyyC17	A: a/b three-layered sandwiches	X: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)	T: UDP-Glycosyltransferase/glycogen phosphorylase	F: Glyco_transf_41_3rd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
A	3.40.50.11380	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.30.720.150	Alpha Beta	2-Layer Sandwich	Signal recognition particle alu RNA binding heterodimer, srp9/1		CATH (4.3.0)
A	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)
C	1.25.40.10	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Tetratricopeptide repeat domain	CATH (4.3.0)
C	3.40.50.11380	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.30.720.150	Alpha Beta	2-Layer Sandwich	Signal recognition particle alu RNA binding heterodimer, srp9/1		CATH (4.3.0)
C	3.40.50.2000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Glycogen Phosphorylase B	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF13844	Glycosyl transferase family 41 (Glyco_transf_41)	Glycosyl transferase family 41	-	Family
A, C	PF13414	TPR repeat (TPR_11)	TPR repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	UDP-glycosyltransferase activity glycosyltransferase activity acetylglucosaminyltransferase activity transferase activity hexosyltransferase activity catalytic activity catalytic activity, acting on a protein protein O-acetylglucosaminyltransferase activity DNA binding binding chromatin binding organic cyclic compound binding nucleic acid binding chromatin DNA binding UDP-glycosyltransferase activity glycosyltransferase activity acetylglucosaminyltransferase activity transferase activity hexosyltransferase activity catalytic activity catalytic activity, acting on a protein protein O-acetylglucosaminyltransferase activity DNA binding binding chromatin binding organic cyclic compound binding nucleic acid binding chromatin DNA binding ion binding phosphatidylinositol-3,4,5-trisphosphate binding anion binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding	cellular response to stimulus regulation of biological process regulation of signaling small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling regulation of small GTPase mediated signal transduction Rac protein signal transduction biological regulation regulation of signal transduction intracellular signal transduction regulation of Rac protein signal transduction cell communication regulation of intracellular signal transduction cellular response to stimulus regulation of biological process regulation of signaling small GTPase-mediated signal transduction regulation of cellular process response to stimulus signaling regulation of small GTPase mediated signal transduction Rac protein signal transduction biological regulation regulation of signal transduction intracellular signal transduction regulation of Rac protein signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication cellular process signal transduction negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process protein metabolic process negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal apoptotic process cell death programmed cell death developmental process cellular developmental process hemopoiesis cell differentiation anatomical structure development cell development ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process pyruvate metabolic process cellular metabolic process purine nucleoside diphosphate metabolic process regulation of cellular metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process regulation of biosynthetic process rhythmic process circadian regulation of gene expression cellular biosynthetic process circadian rhythm gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process negative regulation of proteolysis negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process regulation of ubiquitin-dependent protein catabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis modification-dependent macromolecule catabolic process proteolysis negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process proteasomal protein catabolic process protein catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process regulation of protein catabolic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of metabolic process positive regulation of proteolysis positive regulation of macromolecule metabolic process negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus negative regulation of signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion necroptotic process programmed necrotic cell death regulation of programmed cell death regulation of necroptotic process regulation of programmed necrotic cell death multicellular organismal process regulation of cellular component organization cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly regulation of synapse structure or activity regulation of synapse assembly synapse organization cellular component organization or biogenesis regulation of biological quality system development nervous system development regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly regulation of developmental process negative regulation of developmental process regulation of stem cell population maintenance stem cell population maintenance negative regulation of stem cell population maintenance regulation of multicellular organismal process maintenance of cell number negative regulation of multicellular organismal process regulation of transcription from RNA polymerase II promoter by glucose carbon catabolite regulation of transcription positive regulation of macromolecule biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of transcription by glucose regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process cellular response to nutrient levels carbon catabolite regulation of transcription from RNA polymerase II promoter carbon catabolite activation of transcription from RNA polymerase II promoter response to chemical regulation of DNA-templated transcription carbon catabolite activation of transcription response to nutrient levels positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process positive regulation of transcription from RNA polymerase II promoter by glucose RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process response to nutrient nucleobase-containing compound biosynthetic process nucleic acid metabolic process cellular response to chemical stimulus positive regulation of RNA biosynthetic process cellular response to nutrient regulation of transcription by glucose positive regulation of cellular biosynthetic process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process glycoprotein metabolic process protein glycosylation glycosylation macromolecule glycosylation protein O-linked glycosylation chromatin organization monosaccharide metabolic process gluconeogenesis regulation of glucose metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process glucose metabolic process homeostatic process response to oxygen-containing compound cellular response to glucose stimulus intracellular glucose homeostasis cellular response to oxygen-containing compound response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway response to biotic stimulus non-canonical inflammasome complex assembly immune response-activating signaling pathway inflammasome-mediated signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway negative regulation of non-canonical inflammasome complex assembly negative regulation of cellular component organization immune response response to other organism regulation of innate immune response response to external stimulus regulation of inflammasome-mediated signaling pathway negative regulation of protein-containing complex assembly defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway negative regulation of cytoplasmic pattern recognition receptor signaling pathway negative regulation of intracellular signal transduction regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus regulation of protein-containing complex assembly positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response protein-containing complex assembly response to external biotic stimulus positive regulation of innate immune response defense response protein-containing complex organization defense response to symbiont negative regulation of immune system process immune system process negative regulation of inflammasome-mediated signaling pathway positive regulation of developmental process positive regulation of stem cell population maintenance positive regulation of multicellular organismal process protein maturation protein processing regulation of lipid metabolic process lipid biosynthetic process positive regulation of lipid biosynthetic process positive regulation of lipid metabolic process regulation of lipid biosynthetic process lipid metabolic process cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway response to hormone cellular response to hormone stimulus regulation of insulin receptor signaling pathway cellular response to peptide hormone stimulus response to nitrogen compound response to insulin cellular response to insulin stimulus positive regulation of cell communication positive regulation of signal transduction positive regulation of TORC1 signaling positive regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling positive regulation of intracellular signal transduction TORC1 signaling positive regulation of signaling positive regulation of translation post-transcriptional regulation of gene expression translation positive regulation of gene expression regulation of translation adaptive thermogenesis multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis protein localization regulation of localization cellular localization protein localization to synapse regulation of protein localization regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane localization cellular macromolecule localization regulation of protein localization to membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels regulation of cellular localization macromolecule localization protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse cellular catabolic process mitophagy macroautophagy autophagy autophagy of mitochondrion process utilizing autophagic mechanism	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane cytosol membrane-bounded organelle mitochondrial membrane intracellular anatomical structure mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane cytosol synapse cell junction glutamatergic synapse protein-containing complex catalytic complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex intracellular non-membrane-bounded organelle protein acetyltransferase complex intracellular protein-containing complex non-membrane-bounded organelle Sin3-type complex nucleus membrane-enclosed lumen nuclear chromosome nuclear protein-containing complex intracellular organelle lumen histone deacetylase complex organelle lumen nucleoplasm nuclear lumen cell periphery plasma membrane NSL complex H4 histone acetyltransferase complex protein N-acetylglucosaminyltransferase complex cell projection
B, D	Casein kinase II subunit alpha	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups Hsp90 protein binding protein binding binding heat shock protein binding catalytic activity, acting on a protein protein kinase activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor adenyl ribonucleotide binding nucleotide binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups Hsp90 protein binding protein binding binding heat shock protein binding catalytic activity, acting on a protein protein kinase activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity identical protein binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of growth regulation of cellular process regulation of cellular component organization positive regulation of biological process biological regulation growth positive regulation of cell growth cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of biological process regulation of growth regulation of cellular process regulation of cellular component organization positive regulation of biological process biological regulation growth positive regulation of cell growth regulation of cell growth cell growth cellular component organization positive regulation of growth cellular component organization or biogenesis positive regulation of cellular process regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress negative regulation of biological process regulation of primary metabolic process negative regulation of DNA repair nucleobase-containing compound metabolic process regulation of response to stress negative regulation of double-strand break repair negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process recombinational repair regulation of nucleobase-containing compound metabolic process negative regulation of double-strand break repair via homologous recombination double-strand break repair via homologous recombination DNA repair negative regulation of macromolecule metabolic process double-strand break repair negative regulation of response to stimulus negative regulation of metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination negative regulation of DNA recombination regulation of response to stimulus metabolic process negative regulation of DNA metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process negative regulation of hydrolase activity negative regulation of proteolysis regulation of catalytic activity negative regulation of catalytic activity regulation of programmed cell death negative regulation of endopeptidase activity negative regulation of peptidase activity regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity negative regulation of cysteine-type endopeptidase activity involved in apoptotic process protein metabolic process negative regulation of protein metabolic process regulation of cysteine-type endopeptidase activity negative regulation of programmed cell death regulation of protein metabolic process regulation of apoptotic process regulation of peptidase activity negative regulation of molecular function cell death regulation of molecular function negative regulation of apoptotic process regulation of hydrolase activity negative regulation of cysteine-type endopeptidase activity apoptotic process programmed cell death cellular biosynthetic process negative regulation of cellular metabolic process post-transcriptional regulation of gene expression negative regulation of translation regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of protein stability regulation of biological quality protein stabilization chaperone-mediated protein folding protein maturation protein folding catabolic process positive regulation of protein metabolic process protein catabolic process regulation of catabolic process positive regulation of protein catabolic process macromolecule catabolic process positive regulation of catabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of protein catabolic process protein phosphorylation phosphorylation macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation signaling signal transduction cell communication negative regulation of proteolysis involved in protein catabolic process proteolysis involved in protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of ubiquitin-dependent protein catabolic process negative regulation of protein catabolic process regulation of proteolysis involved in protein catabolic process modification-dependent macromolecule catabolic process negative regulation of ubiquitin-dependent protein catabolic process negative regulation of catabolic process negative regulation of proteasomal ubiquitin-dependent protein catabolic process proteasomal protein catabolic process regulation of proteasomal ubiquitin-dependent protein catabolic process modification-dependent protein catabolic process negative regulation of proteasomal protein catabolic process regulation of proteasomal protein catabolic process ubiquitin-dependent protein catabolic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation negative regulation of signaling regulation of signal transduction negative regulation of cell communication negative regulation of apoptotic signaling pathway regulation of signaling negative regulation of signal transduction apoptotic signaling pathway regulation of cell communication regulation of apoptotic signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway Wnt signaling pathway cell surface receptor signaling pathway regulation of Wnt signaling pathway positive regulation of signaling macroautophagy autophagy positive regulation of cellular metabolic process regulation of autophagy positive regulation of aggrephagy cellular catabolic process aggrephagy positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of autophagy regulation of aggrephagy regulation of macroautophagy regulation of cellular catabolic process positive regulation of cellular catabolic process symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms symbiont-mediated disruption of host cell PML body symbiont-mediated disruption of host cellular anatomical entity disruption of anatomical structure in another organism rhythmic process regulation of chromosome segregation regulation of cell cycle process chromosome separation regulation of chromosome separation cell cycle regulation of cell cycle chromosome segregation cell cycle process peptidyl-serine modification peptidyl-serine phosphorylation	membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex Sin3-type complex nucleus membrane-enclosed lumen nuclear chromosome nuclear protein-containing complex chromosome chromatin intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure catalytic complex Sin3-type complex nucleus membrane-enclosed lumen nuclear chromosome nuclear protein-containing complex chromosome chromatin intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen histone deacetylase complex intracellular organelle organelle lumen nucleoplasm organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cytoplasm cytosol cell periphery plasma membrane membrane protein kinase complex transferase complex, transferring phosphorus-containing groups protein kinase CK2 complex serine/threonine protein kinase complex transferase complex intracellular protein-containing complex nuclear body PML body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR019734	Tetratricopeptide repeat	Repeat
A, C	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, C	IPR029489	O-GlcNAc transferase, C-terminal	Domain
B, D	IPR045216	Casein Kinase 2, subunit alpha	Family
B, D	IPR017441	Protein kinase, ATP binding site	Binding Site
B, D	IPR000719	Protein kinase domain	Domain
B, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, D	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: O15294	Pick disease subependymal giant cell astrocytoma Alzheimer disease B-cell chronic lymphocytic leukemia glioblastoma intellectual disability, X-linked 106 medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma progressive supranuclear palsy astrocytic tumor cystic fibrosis hereditary spastic paraplegia malignant colon neoplasm MENTAL RETARDATION, X-LINKED 106 Pick disease subependymal giant cell astrocytoma Alzheimer disease B-cell chronic lymphocytic leukemia glioblastoma intellectual disability, X-linked 106 medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma progressive supranuclear palsy astrocytic tumor cystic fibrosis hereditary spastic paraplegia malignant colon neoplasm MENTAL RETARDATION, X-LINKED 106 ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor dermatomyositis intellectual disability malignant ependymoma oligodendroglioma pancreatic ductal adenocarcinoma
B, D	Pharos: P68400	squamous cell carcinoma adult T-cell leukemia/lymphoma Okur-Chung neurodevelopmental syndrome skin cancer intellectual disability skin neoplasm acute T cell leukemia large cell medulloblastoma medulloblastoma osteosarcoma rheumatoid arthritis lung cancer non-small cell lung carcinoma ovarian cancer Malformations of Cortical Development squamous cell carcinoma adult T-cell leukemia/lymphoma Okur-Chung neurodevelopmental syndrome skin cancer intellectual disability skin neoplasm acute T cell leukemia large cell medulloblastoma medulloblastoma osteosarcoma rheumatoid arthritis lung cancer non-small cell lung carcinoma ovarian cancer Malformations of Cortical Development pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.