4H04

Lacto-N-biosidase from Bifidobacterium bifidum

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RicinB_lectin_2	e4h04A3	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: RicinB_lectin_2	ECOD (1.6)
A	Glyco_hydro_20	e4h04A1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_20	ECOD (1.6)
A	Glyco_hydro_20b,RNAse_Pc_like	e4h04A2	A: mixed a+b and a/b	X: Zincin-like	H: beta-N-acetylhexosaminidase-like domain (From Topology)	T: beta-N-acetylhexosaminidase-like domain	F: Glyco_hydro_20b,RNAse_Pc_like	ECOD (1.6)
B	RicinB_lectin_2	e4h04B12	A: beta duplicates or obligate multimers	X: beta-Trefoil (From Topology)	H: beta-Trefoil (From Topology)	T: beta-Trefoil	F: RicinB_lectin_2	ECOD (1.6)
B	Glyco_hydro_20	e4h04B10	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_20	ECOD (1.6)
B	Glyco_hydro_20b,RNAse_Pc_like	e4h04B11	A: mixed a+b and a/b	X: Zincin-like	H: beta-N-acetylhexosaminidase-like domain (From Topology)	T: beta-N-acetylhexosaminidase-like domain	F: Glyco_hydro_20b,RNAse_Pc_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.379.10	Alpha Beta	2-Layer Sandwich	Chitobiase	domain 2	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)
B	3.30.379.10	Alpha Beta	2-Layer Sandwich	Chitobiase	domain 2	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	2.80.10.50	Mainly Beta	Trefoil	Trefoil (Acidic Fibroblast Growth Factor, subunit A)		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02838	Glycosyl hydrolase family 20, domain 2 (Glyco_hydro_20b)	Glycosyl hydrolase family 20, domain 2	This domain has a zincin-like fold.	Domain
A, B	PF00728	Glycosyl hydrolase family 20, catalytic domain (Glyco_hydro_20)	Glycosyl hydrolase family 20, catalytic domain	This domain has a TIM barrel fold.	Domain
A, B	PF14200	Ricin-type beta-trefoil lectin domain-like (RicinB_lectin_2)	Ricin-type beta-trefoil lectin domain-like	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Lacto-N-biosidase	hydrolase activity, acting on glycosyl bonds lacto-N-biosidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity hexosaminidase activity beta-N-acetylhexosaminidase activity	carbohydrate metabolic process primary metabolic process metabolic process	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B	IPR029018	Beta-hexosaminidase-like, domain 2	Homologous Superfamily
A, B	IPR015883	Glycoside hydrolase family 20, catalytic domain	Domain
A, B	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B	IPR003343	Bacterial Ig-like domain, group 2	Domain
A, B	IPR000421	Coagulation factor 5/8, C-terminal domain	Domain
A, B	IPR035992	Ricin B-like lectins	Homologous Superfamily
A, B	IPR052764	Glycosyl Hydrolase 20 Enzymes	Family
A, B	IPR025705	Beta-hexosaminidase	Family
A, B	IPR015882	Beta-hexosaminidase, bacterial type, N-terminal	Domain
A, B	IPR008964	Invasin/intimin cell-adhesion fragments	Homologous Superfamily
A, B	IPR000772	Ricin B, lectin domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.