4HT2

Crystal structure of human carbonic anhydrase isozyme XII with the inhibitor.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4ht2b_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4ht2a_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4ht2c_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4ht2d_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	Carbonic anhydrase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Carbonic anhydrase	8034342	3001672	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Carbonic anhydrase	8034342	3001672	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Carbonic anhydrase	8034342	3001672	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Carbonic anhydrase	8034342	3001672	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Carb_anhydrase	e4ht2B1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
A	Carb_anhydrase	e4ht2A1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
C	Carb_anhydrase	e4ht2C1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
D	Carb_anhydrase	e4ht2D1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
A	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
C	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
D	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Carbonic anhydrase 12	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process ovulation cycle rhythmic process estrous cycle reproductive process multicellular organismal reproductive process inorganic ion homeostasis chemical homeostasis homeostatic process monoatomic ion homeostasis chloride ion homeostasis monoatomic anion homeostasis	membrane cellular anatomical entity cell periphery apical part of cell plasma membrane plasma membrane region apical plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018338	Carbonic anhydrase, alpha-class, conserved site	Conserved Site
A, B, C, D	IPR001148	Alpha carbonic anhydrase domain	Domain
A, B, C, D	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A, B, C, D	IPR023561	Carbonic anhydrase, alpha-class	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: O43570	isolated hyperchlorhidrosis Lung Neoplasms nephrosclerosis adrenal cortex carcinoma open-angle glaucoma atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma breast fibroadenoma cystic fibrosis sinusitis glioblastoma lung cancer malignant colon neoplasm malignant glioma malignant pancreatic neoplasm isolated hyperchlorhidrosis Lung Neoplasms nephrosclerosis adrenal cortex carcinoma open-angle glaucoma atypical teratoid rhabdoid tumor pancreatic ductal adenocarcinoma breast fibroadenoma cystic fibrosis sinusitis glioblastoma lung cancer malignant colon neoplasm malignant glioma malignant pancreatic neoplasm non-small cell lung carcinoma angle-closure glaucoma osteosarcoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia childhood absence epilepsy psoriasis dental caries subependymal giant cell astrocytoma heart disease large cell medulloblastoma lung carcinoma malignant ependymoma malignant mesothelioma medulloblastoma oligodendroglioma ovarian cancer breast carcinoma cutaneous lupus erythematosus ulcerative colitis interstitial cystitis lung benign neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.