4IE2

Crystal structure of human Arginase-2 complexed with inhibitor 1h

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d4ie2b_	Alpha and beta proteins (a/b)	Arginase/deacetylase	Arginase/deacetylase	Arginase-like amidino hydrolases	Arginase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4ie2a_	Alpha and beta proteins (a/b)	Arginase/deacetylase	Arginase/deacetylase	Arginase-like amidino hydrolases	Arginase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4ie2c_	Alpha and beta proteins (a/b)	Arginase/deacetylase	Arginase/deacetylase	Arginase-like amidino hydrolases	Arginase	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Arginase/deacetylase-like	8039065	3000260	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Arginase/deacetylase-like	8039065	3000260	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Arginase/deacetylase-like	8039065	3000260	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Arginase	e4ie2B1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Arginase/deacetylase	F: Arginase	ECOD (1.6)
A	Arginase	e4ie2A1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Arginase/deacetylase	F: Arginase	ECOD (1.6)
C	Arginase	e4ie2C1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Arginase/deacetylase	F: Arginase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.800.10	Alpha Beta	3-Layer(aba) Sandwich	Arginase	Chain A	CATH (4.3.0)
A	3.40.800.10	Alpha Beta	3-Layer(aba) Sandwich	Arginase	Chain A	CATH (4.3.0)
C	3.40.800.10	Alpha Beta	3-Layer(aba) Sandwich	Arginase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00491	Arginase family (Arginase)	Arginase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Arginase-2, mitochondrial	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds arginase activity cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding	multicellular organismal process system process muscle contraction muscle system process striated muscle contraction regulation of tumor necrosis factor production regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process multicellular organismal process system process muscle contraction muscle system process striated muscle contraction regulation of tumor necrosis factor production regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process cellular metabolic process negative regulation of metabolic process biological regulation tumor necrosis factor superfamily cytokine production regulation of cellular metabolic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of metabolic process response to stimulus immune response immune system process adaptive immune response leukocyte apoptotic process regulation of programmed cell death lymphocyte apoptotic process regulation of activated CD8-positive, alpha-beta T cell apoptotic process negative regulation of leukocyte apoptotic process activated CD8-positive, alpha-beta T cell apoptotic process regulation of T cell apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process negative regulation of programmed cell death regulation of apoptotic process cell death negative regulation of T cell apoptotic process negative regulation of apoptotic process negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process T cell apoptotic process apoptotic process programmed cell death negative regulation of lymphocyte apoptotic process biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism response to stress innate immune response response to external biotic stimulus negative regulation of response to stimulus negative regulation of immune response negative regulation of type 2 immune response type 2 immune response regulation of response to stimulus negative regulation of immune system process regulation of type 2 immune response regulation of immune response regulation of immune system process ornithine metabolic process arginine catabolic process to ornithine catabolic process oxoacid metabolic process glutamine family amino acid catabolic process amino acid metabolic process arginine catabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process arginine metabolic process non-proteinogenic amino acid metabolic process carboxylic acid catabolic process small molecule metabolic process amino acid catabolic process carboxylic acid metabolic process L-amino acid catabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process small molecule catabolic process negative regulation of chemokine production regulation of chemokine (C-C motif) ligand 4 production negative regulation of chemokine (C-C motif) ligand 4 production chemokine (C-C motif) ligand 4 production regulation of chemokine production chemokine production regulation of defense response regulation of response to biotic stimulus negative regulation of response to biotic stimulus regulation of response to external stimulus defense response to bacterium regulation of response to stress response to bacterium regulation of defense response to bacterium negative regulation of defense response to bacterium negative regulation of response to external stimulus negative regulation of defense response chemokine (C-C motif) ligand 5 production negative regulation of chemokine (C-C motif) ligand 5 production regulation of chemokine (C-C motif) ligand 5 production ureteric bud development developmental process mesonephric epithelium development epithelium development kidney epithelium development mesonephros development tube development animal organ development tissue development renal system development multicellular organism development anatomical structure development kidney development mesonephric tubule development system development cellular response to stimulus regulation of cellular senescence positive regulation of biological process cellular senescence positive regulation of cellular metabolic process positive regulation of metabolic process positive regulation of cellular senescence cellular response to stress positive regulation of cellular process reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process regulation of reactive oxygen species metabolic process interleukin-17 production negative regulation of interleukin-17 production regulation of interleukin-17 production negative regulation of lymphocyte proliferation regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation alpha-beta T cell proliferation T cell activation lymphocyte proliferation alpha-beta T cell activation regulation of leukocyte proliferation cell population proliferation regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion mononuclear cell proliferation regulation of cell population proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation regulation of alpha-beta T cell proliferation cell adhesion cell-cell adhesion CD4-positive, alpha-beta T cell activation regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation CD4-positive, alpha-beta T cell proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell activation negative regulation of CD4-positive, alpha-beta T cell proliferation regulation of mononuclear cell proliferation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation interleukin-1 production regulation of interleukin-1 beta production regulation of interleukin-1 production interleukin-1 beta production interleukin-13 production negative regulation of interleukin-13 production regulation of interleukin-13 production nitrogen cycle metabolic process urea cycle amide biosynthetic process amide metabolic process urea metabolic process negative regulation of macrophage inflammatory protein 1 alpha production macrophage inflammatory protein-1 alpha production regulation of macrophage inflammatory protein 1 alpha production nitric oxide metabolic process nitric oxide biosynthetic process reactive nitrogen species metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR014033	Arginase	Family
A, B, C	IPR020855	Ureohydrolase, manganese-binding site	Binding Site
A, B, C	IPR023696	Ureohydrolase domain superfamily	Homologous Superfamily
A, B, C	IPR006035	Ureohydrolase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P78540	pancreatic ductal adenocarcinoma asthma Necrosis prostate cancer pulmonary hypertension medulloblastoma non-small cell lung carcinoma tuberculosis Crohn disease endometriosis glioblastoma juvenile dermatomyositis lung cancer malignant glioma oligodendroglioma pancreatic ductal adenocarcinoma asthma Necrosis prostate cancer pulmonary hypertension medulloblastoma non-small cell lung carcinoma tuberculosis Crohn disease endometriosis glioblastoma juvenile dermatomyositis lung cancer malignant glioma oligodendroglioma pituitary cancer psoriasis astrocytic tumor esophageal adenocarcinoma hereditary spastic paraplegia large cell medulloblastoma lung carcinoma malignant pancreatic neoplasm nephrosclerosis osteosarcoma atypical teratoid rhabdoid tumor exocrine pancreatic carcinoma interstitial cystitis lung adenocarcinoma malignant ependymoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.