Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4k4ha1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad4k4ha2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad4k4ha3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ad4k4ha4 Artifacts Tags Tags Tags C-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed4k4he1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed4k4he2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed4k4he3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Ed4k4he4 Artifacts Tags Tags Tags C-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Id4k4hi1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Id4k4hi2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Id4k4hi3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Id4k4hi4 Artifacts Tags Tags Tags C-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Md4k4hm1 All alpha proteins SAM domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase beta, N-terminal domain-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Md4k4hm2 All alpha proteins SAM domain-like PsbU/PolX domain-like DNA polymerase beta-like, second domain DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Md4k4hm3 Alpha and beta proteins (a+b) Nucleotidyltransferase Nucleotidyltransferase DNA polymerase beta-like DNA polymerase lambda human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
Md4k4hm4 Artifacts Tags Tags Tags C-terminal Tags human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)
ISCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyDNA polymerase beta, N-terminal domain-like 8037849 3000524 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyNucleotidyltransferase-like 8037852 3000129 SCOP2B (2022-06-29)
MSCOP2B SuperfamilyPsbU/PolX domain-like 8037850 3000893 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADNA_pol_lambd_fe4k4hA2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
AHHH_8e4k4hA3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
ADNA_pol_B_palme4k4hA1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
EDNA_pol_lambd_fe4k4hE2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
EHHH_8e4k4hE3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
EDNA_pol_B_palme4k4hE1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
IDNA_pol_lambd_fe4k4hI2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
IHHH_8e4k4hI3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
IDNA_pol_B_palme4k4hI1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)
MDNA_pol_lambd_fe4k4hM2 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: DNA_pol_lambd_fECOD (1.6)
MHHH_8e4k4hM3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_8ECOD (1.6)
MDNA_pol_B_palme4k4hM1 A: a+b three layersX: Nucleotidyltransferase-likeH: Nucleotidyltransferase (From Topology)T: NucleotidyltransferaseF: DNA_pol_B_palmECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, E, I, M
PF14716Helix-hairpin-helix domain (HHH_8)Helix-hairpin-helix domain- Domain
A, E, I, M
PF14791DNA polymerase beta thumb (DNA_pol_B_thumb)DNA polymerase beta thumb- Family
A, E, I, M
PF14792DNA polymerase beta palm (DNA_pol_B_palm)DNA polymerase beta palmThe catalytic region of DNA polymerase beta is split into three domains. An N-terminal fingers domain, a central palm domain and a C-terminal thumb domain. This entry represents the palm domain [1].Domain
A, E, I, M
PF10391Fingers domain of DNA polymerase lambda (DNA_pol_lambd_f)Fingers domain of DNA polymerase lambdaDNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the centr ...DNA polymerases catalyse the addition of dNMPs onto the 3-prime ends of DNA chains. There is a general polymerase fold consisting of three subdomains that have been likened to the fingers, palm, and thumb of a right hand. DNA_pol_lambd_f is the central three-helical region of DNA polymerase lambda referred to as the F and G helices of the fingers domain. Contacts with DNA involve this conserved helix-hairpin-helix motif in the fingers region which interacts with the primer strand. This motif is common to several DNA binding proteins and confers a sequence-independent interaction with the DNA backbone [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, E, I, M
DNA polymerase lambda
B, F, J, N
DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3')---
C, G, K, O
DNA (5'-D(*CP*AP*GP*TP*AP*C)-3')---
D, H, L, P
DNA (5'-D(P*GP*CP*CP*G)-3')---

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, E, I, M
PharosQ9UGP5