4K5Y

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	G protein-coupled receptor-like	8091128	3000473	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lysozyme-like	8033861	3001879	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	G protein-coupled receptor-like	8091128	3000473	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	G protein-coupled receptor-like	8091128	3000473	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	7tm_2	e4k5yA2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_2	ECOD (1.6)
A	Phage_lysozyme_2	e4k5yA1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
B	7tm_2	e4k5yB2	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_2	ECOD (1.6)
B	Phage_lysozyme_2	e4k5yB1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: Phage_lysozyme_2	ECOD (1.6)
C	7tm_2	e4k5yC1	A: alpha bundles	X: Family A G protein-coupled receptor-like (From Topology)	H: Family A G protein-coupled receptor-like (From Topology)	T: Family A G protein-coupled receptor-like	F: 7tm_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.3.0)
A	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
B	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.3.0)
B	1.10.530.40	Mainly Alpha	Orthogonal Bundle	Lysozyme		CATH (4.3.0)
C	1.20.1070.10	Mainly Alpha	Up-down Bundle	Rhopdopsin 7-helix transmembrane proteins	Rhodopsin 7-helix transmembrane proteins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A, B, C	PF00002	7 transmembrane receptor (Secretin family) (7tm_2)	7 transmembrane receptor (Secretin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Corticotropin-releasing factor receptor 1, T4-Lysozyme chimeric construct	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity corticotrophin-releasing factor receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity amide binding binding peptide hormone binding hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity corticotrophin-releasing factor receptor activity molecular transducer activity G protein-coupled receptor activity transmembrane signaling receptor activity signaling receptor activity amide binding binding peptide hormone binding hormone binding corticotropin-releasing hormone binding peptide receptor activity G protein-coupled peptide receptor activity	biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus carbohydrate derivative catabolic process catabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process metabolic process macromolecule metabolic process symbiont-mediated cytolysis of host cell viral life cycle disruption of cell in another organism cytolysis biological process involved in interaction with host biological process involved in symbiotic interaction viral release from host cell by cytolysis disruption of cellular anatomical structure in another organism exit from host cell viral process cytolysis in another organism cellular process viral release from host cell disruption of anatomical structure in another organism symbiont-mediated killing of host cell killing of cells of another organism cell killing disruption of plasma membrane integrity in another organism cell wall organization or biogenesis cell wall macromolecule catabolic process cell wall macromolecule metabolic process cellular response to nitrogen compound cellular response to stimulus response to corticotropin-releasing hormone response to endogenous stimulus response to peptide hormone cellular response to peptide hormone stimulus response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to corticotropin-releasing hormone stimulus cellular response to hormone stimulus multicellular organismal process system process nitrogen compound transport transport signaling hormone secretion cell communication peptide secretion localization secretion by cell amide transport signal release regulation of biological quality regulation of biological process secretion corticotropin secretion regulation of hormone levels biological regulation cell-cell signaling export from cell establishment of localization peptide transport endocrine hormone secretion endocrine process peptide hormone secretion hormone transport behavior exploration behavior multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process immune response immune system process regulation of localization corticosterone secretion regulation of cellular process regulation of system process regulation of glucocorticoid secretion regulation of steroid hormone secretion lipid transport regulation of corticosteroid hormone secretion regulation of secretion lipid export from cell glucocorticoid secretion regulation of endocrine process corticosteroid hormone secretion regulation of corticosterone secretion regulation of hormone secretion steroid hormone secretion regulation of lipid transport organic hydroxy compound transport regulation of secretion by cell regulation of multicellular organismal process regulation of signaling regulation of transport lipid localization regulation of lipid localization macromolecule localization regulation of cell communication general adaptation syndrome general adaptation syndrome, behavioral process multicellular organismal response to stress parturition fear response adult behavior response to alcohol behavioral response to ethanol response to ethanol adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction cell surface receptor signaling pathway regulation of catalytic activity regulation of lyase activity regulation of molecular function regulation of adenylate cyclase activity regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway regulation of cyclase activity developmental process multicellular organism development adrenal gland development endocrine system development anatomical structure development gland development animal organ development system development positive regulation of adenylate cyclase activity positive regulation of cyclase activity positive regulation of catalytic activity positive regulation of molecular function activation of adenylate cyclase activity positive regulation of lyase activity regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport negative regulation of voltage-gated calcium channel activity negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity negative regulation of biological process negative regulation of transport regulation of voltage-gated calcium channel activity calcium ion transport negative regulation of cation transmembrane transport monoatomic cation transport regulation of monoatomic ion transport inorganic ion transmembrane transport regulation of cation channel activity inorganic cation transmembrane transport transmembrane transport regulation of transmembrane transport negative regulation of calcium ion transmembrane transport negative regulation of cation channel activity monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of transmembrane transporter activity regulation of monoatomic ion transmembrane transport metal ion transport negative regulation of transmembrane transport regulation of transporter activity regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport negative regulation of monoatomic ion transmembrane transport negative regulation of cellular process monoatomic ion transport regulation of metal ion transport regulation of monoatomic ion transmembrane transporter activity negative regulation of transporter activity negative regulation of molecular function negative regulation of calcium ion transport regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport	host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity membrane cell periphery plasma membrane cell projection neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular anatomical structure host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity membrane cell periphery plasma membrane cell projection neuron projection plasma membrane bounded cell projection membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR052619	Bacteriophage lysozyme-like	Family
A, B, C	IPR001165	T4-type lysozyme	Family
A, B, C	IPR034690	Endolysin T4 type	Family
A, B, C	IPR002196	Glycoside hydrolase, family 24	Family
A, B, C	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A, B, C	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
A, B, C	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
A, B, C	IPR050332	G-protein coupled receptor 2	Family
A, B, C	IPR003052	GPCR, family 2, corticotropin releasing factor receptor, type 1	Family
A, B, C	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
A, B, C	IPR000832	GPCR, family 2, secretin-like	Family
A, B, C	IPR003051	GPCR, family 2, corticotropin releasing factor receptor	Family
A, B, C	IPR017981	GPCR, family 2-like, 7TM	Domain
A, B, C	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: P34998	major depressive disorder Pain, Postoperative cocaine abuse contact dermatitis cocaine dependence anxiety disorder depressive disorder glioblastoma atypical teratoid rhabdoid tumor breast carcinoma psoriasis malignant ependymoma bipolar disorder cancer pilocytic astrocytoma major depressive disorder Pain, Postoperative cocaine abuse contact dermatitis cocaine dependence anxiety disorder depressive disorder glioblastoma atypical teratoid rhabdoid tumor breast carcinoma psoriasis malignant ependymoma bipolar disorder cancer pilocytic astrocytoma endogenous depression idiopathic pulmonary fibrosis androgenetic alopecia large cell medulloblastoma malignant glioma mood disorder breast cancer osteoarthritis, hip chronic obstructive pulmonary disease primitive neuroectodermal tumor

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C	OPM	Transmembrane	Alpha-helical polytopic	Rhodopsin-like receptors and pumps	GPCR Secretin (B) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B, C	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	G Protein-Coupled Receptors: Class B1	Corticotropin-releasing factor receptor 1 (CRF1R) in complex with CP-376395 small-molecule antagonist

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.