Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
BFlavi_NS5_2nde4k6mB5 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: Flavi_NS5_2ndECOD (1.6)
BFlavi_NS5_1ste4k6mB4 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: Flavi_NS5_1stECOD (1.6)
BFtsJe4k6mB6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: FtsJECOD (1.6)
AFlavi_NS5_2nde4k6mA5 A: alpha bundlesX: helical bundle domain in reverse transcriptase-like polymerases (From Topology)H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)T: helical bundle domain in reverse transcriptase-like polymerasesF: Flavi_NS5_2ndECOD (1.6)
AFlavi_NS5_1ste4k6mA4 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: Flavi_NS5_1stECOD (1.6)
AFtsJe4k6mA6 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: FtsJECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
B3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
A3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF20483Flavivirus RNA-directed RNA polymerase, thumb domain (Flavi_NS5_thumb)Flavivirus RNA-directed RNA polymerase, thumb domainFlaviviruses produce a large polyprotein from the ssRNA genome, encoding structural proteins required for virus assembly and non-structural (NS1-5) proteins involved in replication of the viral genome [1,2,3]. This polyprotein is cleaved by viral and ...Flaviviruses produce a large polyprotein from the ssRNA genome, encoding structural proteins required for virus assembly and non-structural (NS1-5) proteins involved in replication of the viral genome [1,2,3]. This polyprotein is cleaved by viral and cellular proteases to produce mature viral proteins. NS5 is the largest mature viral protein and contains a N-terminal methyltransferase (MTase) domain separated by a short linker from the C-terminal RNA-directed RNA polymerase domain (RdRp) that adopts a characteristic right-handed fingers-palm-thumb fold and possesses a number of short regions and motifs homologous to other RNA-directed RNA polymerases [2,3]. This entry represents the thumb domain of NS5 RdRp. NS5 binds to a the stem loop A (SLA) at the 5' extremity of Flavivirus genome and regulates translation of the viral genome [3].
Domain
A, B
PF01728FtsJ-like methyltransferase (FtsJ)FtsJ-like methyltransferase- Family
A, B
PF00972Flavivirus RNA-directed RNA polymerase, fingers and palm domains (Flavi_NS5)Flavivirus RNA-directed RNA polymerase, fingers and palm domainsFlaviviruses produce a large polyprotein from the ssRNA genome, encoding structural proteins required for virus assembly and non-structural (NS1-5) proteins involved in replication of the viral genome [1-6]. This polyprotein is cleaved by viral and c ...Flaviviruses produce a large polyprotein from the ssRNA genome, encoding structural proteins required for virus assembly and non-structural (NS1-5) proteins involved in replication of the viral genome [1-6]. This polyprotein is cleaved by viral and cellular proteases to produce mature viral proteins. NS5 is the largest mature viral protein and contains a N-terminal methyltransferase (MTase) domain separated by a short linker from the C-terminal RNA-directed RNA polymerase domain (RdRp) that adopts a characteristic right-handed fingers-palm-thumb fold and possesses a number of short regions and motifs homologous to other RNA-directed RNA polymerases [2,5,6]. This entry covers the fingers and palm domains of RNA-directed RNA polymerase (RdRp) from Flavivirus NS5. NS5 binds to a the stem loop A (SLA) at the 5' extremity of Flavivirus genome and regulates translation of the viral genome [5,6].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Polyprotein

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR000208RNA-directed RNA polymerase, fingers/palm subdomains, flavivirusDomain
A, B
IPR014756Immunoglobulin E-setHomologous Superfamily
A, B
IPR001122Capsid protein C, flavivirusDomain
A, B
IPR027287Glycoprotein E, immunoglobulin-like domain, flavivirusDomain
A, B
IPR014412Genome polyprotein, FlavivirusFamily
A, B
IPR036253Flavivirus glycoprotein, central and dimerisation domain superfamilyHomologous Superfamily
A, B
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, B
IPR026490mRNA cap 0/1 methyltransferaseDomain
A, B
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, B
IPR001650Helicase, C-terminal domain-likeDomain
A, B
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
A, B
IPR013755Flaviviral glycoprotein E, central domain, subdomain 1Homologous Superfamily
A, B
IPR000752Flavivirus non-structural protein NS2ADomain
A, B
IPR047530RNA-dependent RNA polymerase, flavivirusDomain
A, B
IPR049486Flavivridae NS3 helicase, C-terminal helical domainDomain
A, B
IPR046811RNA-directed RNA polymerase, thumb subdomain, flavivirusDomain
A, B
IPR038055Flaviviral glycoprotein E, dimerisation domainHomologous Superfamily
A, B
IPR002877Ribosomal RNA methyltransferase, FtsJ domainDomain
A, B
IPR038302Envelope glycoprotein M superfamily, flavivirusHomologous Superfamily
A, B
IPR000069Envelope glycoprotein M, flavivirusDomain
A, B
IPR011492Non-structural protein NS3-like, DEAD box helicase, flavivirusDomain
A, B
IPR038345Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamilyHomologous Superfamily
A, B
IPR038688Flavivirus polyprotein propeptide superfamilyHomologous Superfamily
A, B
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A, B
IPR026470Flavivirus envelope glycoprotein E, Stem/Anchor domainDomain
A, B
IPR011998Envelope glycoprotein E, central and dimerisation domain, flavivirusDomain
A, B
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, B
IPR037172Flavivirus capsid protein C superfamilyHomologous Superfamily
A, B
IPR000404Flavivirus non-structural protein NS4ADomain
A, B
IPR000487Non-structural protein NS2B, flavivirusDomain
A, B
IPR001528Flavivirus non-structural protein NS4BDomain
A, B
IPR001157Non-structural protein NS1, flavivirusDomain
A, B
IPR013756Flaviviral glycoprotein E, central domain, subdomain 2Homologous Superfamily
A, B
IPR001850Non-structural protein NS3, peptidase S7, flavivirusDomain
A, B
IPR000336Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamilyHomologous Superfamily
A, B
IPR002535Flavivirus polyprotein propeptideDomain
A, B
IPR007094RNA-directed RNA polymerase, catalytic domainDomain