4LKT

Crystal Structure of Human Epidermal Fatty Acid Binding Protein (FABP5) in Complex with Linoleic Acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4lkta1	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Epidermal fatty acid binding protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4lkta2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4lktb1	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Epidermal fatty acid binding protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4lktb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4lktc1	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Epidermal fatty acid binding protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d4lktc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4lktd1	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Epidermal fatty acid binding protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d4lktd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lipocalins	8042653	3001332	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lipocalins	8042653	3001332	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lipocalins	8042653	3001332	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lipocalins	8042653	3001332	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lipocalin_7	e4lktA1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
B	Lipocalin_7	e4lktB1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
C	Lipocalin_7	e4lktC1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
D	Lipocalin_7	e4lktD1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)
B	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)
C	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)
D	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00061	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid ...	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Fatty acid-binding protein, epidermal	fatty acid binding organic acid binding binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding long-chain fatty acid transmembrane transporter activity lipid transporter activity lipid transmembrane transporter activity fatty acid transmembrane transporter activity transporter activity fatty acid binding organic acid binding binding ion binding anion binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding long-chain fatty acid transmembrane transporter activity lipid transporter activity lipid transmembrane transporter activity fatty acid transmembrane transporter activity transporter activity monocarboxylic acid transmembrane transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity retinoic acid binding isoprenoid binding retinoid binding identical protein binding protein binding	glycerophospholipid biosynthetic process cellular biosynthetic process cellular metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process glycerophospholipid biosynthetic process cellular biosynthetic process cellular metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phospholipid biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process glycerolipid metabolic process metabolic process cellular process phosphatidylcholine biosynthetic process phosphorus metabolic process lipid metabolic process multicellular organismal process system process transport lipid localization lipid transport vascular transport establishment of localization localization circulatory system process macromolecule localization vascular process in circulatory system lipid transport across blood-brain barrier transport across blood-brain barrier icosanoid metabolic process prostaglandin metabolic process unsaturated fatty acid metabolic process regulation of cellular process oxoacid metabolic process regulation of unsaturated fatty acid biosynthetic process regulation of lipid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process regulation of primary metabolic process prostanoid metabolic process cellular ketone metabolic process icosanoid biosynthetic process regulation of small molecule metabolic process small molecule metabolic process prostaglandin biosynthetic process prostanoid biosynthetic process regulation of biosynthetic process fatty acid metabolic process regulation of biological process regulation of cellular ketone metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process biological regulation carboxylic acid metabolic process regulation of cellular metabolic process fatty acid biosynthetic process regulation of cellular biosynthetic process unsaturated fatty acid biosynthetic process regulation of fatty acid biosynthetic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process regulation of lipid biosynthetic process regulation of metabolic process regulation of prostaglandin biosynthetic process organic anion transport carboxylic acid transport organic acid transport monocarboxylic acid transport fatty acid transport long-chain fatty acid transport nervous system process regulation of system process sensory perception of pain regulation of nervous system process sensory perception regulation of sensory perception regulation of multicellular organismal process regulation of sensory perception of pain regulation of localization hexose transmembrane transport regulation of transport negative regulation of D-glucose transmembrane transport negative regulation of biological process carbohydrate transport negative regulation of transport negative regulation of transmembrane transport transmembrane transport regulation of transmembrane transport D-glucose transmembrane transport negative regulation of cellular process regulation of D-glucose transmembrane transport monosaccharide transmembrane transport carbohydrate transmembrane transport developmental process epidermis development anatomical structure development tissue development trans-synaptic signaling regulation of signaling regulation of retrograde trans-synaptic signaling by endocanabinoid signaling trans-synaptic signaling by endocannabinoid retrograde trans-synaptic signaling cell-cell signaling retrograde trans-synaptic signaling by endocannabinoid cell communication synaptic signaling regulation of trans-synaptic signaling trans-synaptic signaling by lipid regulation of cell communication retrograde trans-synaptic signaling by lipid monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process glucose metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction response to stimulus intracellular receptor signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction signal transduction positive regulation of peroxisome proliferator activated receptor signaling pathway positive regulation of cellular process positive regulation of intracellular signal transduction peroxisome proliferator activated receptor signaling pathway regulation of response to stimulus regulation of peroxisome proliferator activated receptor signaling pathway nuclear receptor-mediated signaling pathway positive regulation of signaling homeostatic process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process chemical homeostasis glucose homeostasis carbohydrate homeostasis	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen secretory granule primary lysosome secretory vesicle nucleus nucleoplasm nuclear lumen cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane secretory granule membrane synapse cell junction postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR012674	Calycin	Homologous Superfamily
A, B, C, D	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain
A, B, C, D	IPR000463	Cytosolic fatty-acid binding	Domain
A, B, C, D	IPR031259	Intracellular lipid binding protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q01469	coronary artery disease myocardial ischemia hepatocellular carcinoma psoriasis Liver carcinoma schizophrenia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.