4LKV

Determinants of lipid substrate and membrane binding for the tetraacyldisaccharide-1-phosphate 4 -kinase LpxK

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	LpxK C-terminal domain-like	8056588	3002352	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Simibi-like P-loop NTPases	8018018	3002018	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Simibi-like P-loop NTPases	8018018	3002018	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LpxK C-terminal domain-like	8056588	3002352	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Simibi-like P-loop NTPases	8018018	3002018	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	LpxK C-terminal domain-like	8056588	3002352	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	LpxK C-terminal domain-like	8056588	3002352	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Simibi-like P-loop NTPases	8018018	3002018	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LpxK_N	e4lkvA2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: LpxK_N	ECOD (1.6)
A	LpxK_C	e4lkvA1	A: a/b three-layered sandwiches	X: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	H: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	T: Tetraacyldisaccharide 4'-kinase C-terminal domain	F: LpxK_C	ECOD (1.6)
B	LpxK_N	e4lkvB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: LpxK_N	ECOD (1.6)
B	LpxK_C	e4lkvB2	A: a/b three-layered sandwiches	X: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	H: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	T: Tetraacyldisaccharide 4'-kinase C-terminal domain	F: LpxK_C	ECOD (1.6)
C	LpxK_N	e4lkvC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: LpxK_N	ECOD (1.6)
C	LpxK_C	e4lkvC2	A: a/b three-layered sandwiches	X: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	H: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	T: Tetraacyldisaccharide 4'-kinase C-terminal domain	F: LpxK_C	ECOD (1.6)
D	LpxK_N	e4lkvD2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: LpxK_N	ECOD (1.6)
D	LpxK_C	e4lkvD1	A: a/b three-layered sandwiches	X: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	H: Tetraacyldisaccharide 4'-kinase C-terminal domain (From Topology)	T: Tetraacyldisaccharide 4'-kinase C-terminal domain	F: LpxK_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02606	Tetraacyldisaccharide-1-P 4'-kinase (LpxK)	Tetraacyldisaccharide-1-P 4'-kinase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Tetraacyldisaccharide 4'-kinase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding tetraacyldisaccharide 4'-kinase activity kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups	lipopolysaccharide biosynthetic process cellular biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process lipopolysaccharide metabolic process lipopolysaccharide core region biosynthetic process polysaccharide metabolic process oligosaccharide biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process oligosaccharide metabolic process cellular metabolic process lipopolysaccharide biosynthetic process cellular biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process lipopolysaccharide metabolic process lipopolysaccharide core region biosynthetic process polysaccharide metabolic process oligosaccharide biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process oligosaccharide metabolic process cellular metabolic process liposaccharide metabolic process primary metabolic process lipopolysaccharide core region metabolic process macromolecule biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process lipid metabolic process glycolipid metabolic process lipid A biosynthetic process phospholipid metabolic process phosphate-containing compound metabolic process lipooligosaccharide biosynthetic process phosphorus metabolic process membrane lipid metabolic process lipooligosaccharide metabolic process glycolipid biosynthetic process phospholipid biosynthetic process lipid A metabolic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process membrane lipid biosynthetic process	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR003758	Tetraacyldisaccharide 4'-kinase	Family
A, B, C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.