4LVD
Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A [auth B] | PRK09198,NAPRTase | e4lvdB3 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: Nicotinate/Quinolinate PRTase N-terminal domain-like | F: PRK09198,NAPRTase | ECOD (1.6) |
A [auth B] | NAPRTase | e4lvdB1 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: NAPRTase | ECOD (1.6) |
A [auth B] | EUF08675 | e4lvdB2 | A: few secondary structure elements | X: Rubredoxin-like | H: Nicotinate phosphoribosyltransferase C-terminal domain-related (From Topology) | T: Nicotinate phosphoribosyltransferase C-terminal domain-related | F: EUF08675 | ECOD (1.6) |
B [auth A] | PRK09198,NAPRTase | e4lvdA3 | A: a+b complex topology | X: alpha/beta-Hammerhead/Barrel-sandwich hybrid | H: alpha/beta-Hammerhead/Barrel-sandwich hybrid | T: Nicotinate/Quinolinate PRTase N-terminal domain-like | F: PRK09198,NAPRTase | ECOD (1.6) |
B [auth A] | NAPRTase | e4lvdA2 | A: a/b barrels | X: TIM beta/alpha-barrel | H: TIM barrels (From Topology) | T: TIM barrels | F: NAPRTase | ECOD (1.6) |
B [auth A] | EUF08675 | e4lvdA1 | A: few secondary structure elements | X: Rubredoxin-like | H: Nicotinate phosphoribosyltransferase C-terminal domain-related (From Topology) | T: Nicotinate phosphoribosyltransferase C-terminal domain-related | F: EUF08675 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A [auth B] | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
B [auth A] | 3.20.20.70 | Alpha Beta | Alpha-Beta Barrel | TIM Barrel | Aldolase class I | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
A [auth B], B [auth A] | PF04095 | Nicotinate phosphoribosyltransferase (NAPRTase) family (NAPRTase) | Nicotinate phosphoribosyltransferase (NAPRTase) family | - | Family |
A [auth B], B [auth A] | PF18127 | Nicotinamide phosphoribosyltransferase, N-terminal domain (NAMPT_N) | Nicotinamide phosphoribosyltransferase, N-terminal domain | This is the N-terminal domain found in Nicotinamide phosphoribosyltransferase (NAMPT) present in Homo sapiens. NAMPT captures nicotinamide (NAM) and replenish the nicotinamide adenine dinucleotide (NAD+) pool during ADP-ribosylation and transferase r ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
A [auth B], B [auth A] | IPR016471 | Nicotinamide phosphoribosyl transferase | Family |
A [auth B], B [auth A] | IPR041525 | Nicotinate/nicotinamide phosphoribosyltransferase | Domain |
A [auth B], B [auth A] | IPR013785 | Aldolase-type TIM barrel | Homologous Superfamily |
A [auth B], B [auth A] | IPR041529 | Nicotinamide phosphoribosyltransferase, N-terminal domain | Domain |
A [auth B], B [auth A] | IPR036068 | Nicotinate phosphoribosyltransferase-like, C-terminal | Homologous Superfamily |