Annotations: 4M8L

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Rib_5-P_isom_A_C	e4m8lA3	A: a+b two layers	X: Alpha-beta plaits	H: D-ribose-5-phosphate isomerase (RpiA), lid domain (From Topology)	T: D-ribose-5-phosphate isomerase (RpiA), lid domain	F: Rib_5-P_isom_A_C	ECOD (1.6)
A	Rib_5-P_isom_A_N	e4m8lA4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Rib_5-P_isom_A_N	ECOD (1.6)
B	Rib_5-P_isom_A_C	e4m8lB3	A: a+b two layers	X: Alpha-beta plaits	H: D-ribose-5-phosphate isomerase (RpiA), lid domain (From Topology)	T: D-ribose-5-phosphate isomerase (RpiA), lid domain	F: Rib_5-P_isom_A_C	ECOD (1.6)
B	Rib_5-P_isom_A_N	e4m8lB4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Rib_5-P_isom_A_N	ECOD (1.6)
C	Rib_5-P_isom_A_C	e4m8lC3	A: a+b two layers	X: Alpha-beta plaits	H: D-ribose-5-phosphate isomerase (RpiA), lid domain (From Topology)	T: D-ribose-5-phosphate isomerase (RpiA), lid domain	F: Rib_5-P_isom_A_C	ECOD (1.6)
C	Rib_5-P_isom_A_N	e4m8lC4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Rib_5-P_isom_A_N	ECOD (1.6)
D	Rib_5-P_isom_A_C	e4m8lD3	A: a+b two layers	X: Alpha-beta plaits	H: D-ribose-5-phosphate isomerase (RpiA), lid domain (From Topology)	T: D-ribose-5-phosphate isomerase (RpiA), lid domain	F: Rib_5-P_isom_A_C	ECOD (1.6)
D	Rib_5-P_isom_A_N	e4m8lD4	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: NagB/RpiA/CoA transferase-like	F: Rib_5-P_isom_A_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
A	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
B	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
C	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)
D	3.40.50.1360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	3.30.70.260	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	ACT domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF06026	Ribose 5-phosphate isomerase A (phosphoriboisomerase A) (Rib_5-P_isom_A)	Ribose 5-phosphate isomerase A (phosphoriboisomerase A)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Ribose-5-phosphate isomerase A	isomerase activity intramolecular oxidoreductase activity, interconverting aldoses and ketoses intramolecular oxidoreductase activity ribose-5-phosphate isomerase activity catalytic activity	monosaccharide metabolic process carbohydrate metabolic process small molecule metabolic process metabolic process primary metabolic process pentose metabolic process D-ribose metabolic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process cellular aldehyde metabolic process monosaccharide metabolic process carbohydrate metabolic process small molecule metabolic process metabolic process primary metabolic process pentose metabolic process D-ribose metabolic process carbohydrate derivative metabolic process glyceraldehyde-3-phosphate metabolic process glucose 6-phosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process cellular aldehyde metabolic process pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process cellular metabolic process generation of precursor metabolites and energy nucleotide metabolic process purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process cellular process pentose-phosphate shunt, non-oxidative branch	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR037171	NagB/RpiA transferase-like	Homologous Superfamily
A, B, C, D	IPR020672	Ribose-5-phosphate isomerase, type A, subgroup	Family
A, B, C, D	IPR004788	Ribose 5-phosphate isomerase, type A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.