4NP2

Crystal structure of the murine CD44 hyaluronan binding domain complex with a small molecule

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4np2a1	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Link domain	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d4np2a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	C-type lectin-like	8077765	3001261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Xlink	e4np2A1	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: Xlink	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00193	Extracellular link domain (Xlink)	Extracellular link domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CD44 antigen	phosphoprotein binding protein binding binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cargo receptor activity transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding signaling receptor binding cytokine receptor binding kinase binding enzyme binding protein kinase binding phosphoprotein binding protein binding binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cargo receptor activity transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding signaling receptor binding cytokine receptor binding kinase binding enzyme binding protein kinase binding epidermal growth factor receptor binding growth factor receptor binding channel regulator activity molecular function regulator activity transporter regulator activity glycosaminoglycan binding carbohydrate derivative binding hyaluronic acid binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process signal transduction multicellular organismal process homeostatic process leukocyte apoptotic process positive regulation of biological process regulation of programmed cell death regulation of neutrophil apoptotic process positive regulation of myeloid cell apoptotic process positive regulation of neutrophil apoptotic process regulation of immune system process myeloid cell homeostasis positive regulation of leukocyte apoptotic process positive regulation of immune system process positive regulation of cellular process regulation of leukocyte apoptotic process myeloid cell apoptotic process positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process neutrophil homeostasis neutrophil apoptotic process multicellular organismal-level homeostasis leukocyte homeostasis immune system process inflammatory cell apoptotic process homeostasis of number of cells apoptotic process programmed cell death regulation of myeloid cell apoptotic process immune response regulation of adaptive immune response adaptive immune response positive regulation of response to stimulus regulation of response to stimulus positive regulation of immune response regulation of immune response positive regulation of adaptive immune response regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process regulation of B cell apoptotic process negative regulation of biological process lymphocyte apoptotic process negative regulation of leukocyte apoptotic process negative regulation of mature B cell apoptotic process negative regulation of cellular process regulation of lymphocyte apoptotic process mature B cell apoptotic process negative regulation of programmed cell death B cell apoptotic process negative regulation of B cell apoptotic process B cell homeostasis negative regulation of apoptotic process regulation of mature B cell apoptotic process lymphocyte homeostasis negative regulation of lymphocyte apoptotic process regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation cell migration cell motility wound healing wound healing involved in inflammatory response defense response response to stress inflammatory response to wounding inflammatory response response to wounding cell adhesion mesonephric epithelium development kidney epithelium development nephron morphogenesis branching morphogenesis of an epithelial tube nephron tubule morphogenesis nephron epithelium morphogenesis nephron tubule development renal system development multicellular organism development ureteric bud morphogenesis tube morphogenesis branching involved in ureteric bud morphogenesis anatomical structure development renal tubule development animal organ morphogenesis epithelial tube morphogenesis nephron development system development nephron epithelium development developmental process ureteric bud development epithelium development tube development mesonephros development animal organ development morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis kidney morphogenesis morphogenesis of a branching structure mesonephric tubule morphogenesis kidney development mesonephric tubule development renal tubule morphogenesis morphogenesis of a branching epithelium mucopolysaccharide metabolic process carbohydrate derivative catabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process plasma membrane bounded cell projection organization cellular developmental process cell projection organization cell development neuron projection development nervous system development generation of neurons neurogenesis neuron differentiation cell differentiation neuron development localization import into cell transport receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling macrophage fusion syncytium formation by plasma membrane fusion anatomical structure formation involved in morphogenesis cell-cell fusion syncytium formation negative regulation of signaling negative regulation of intracellular signal transduction regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator negative regulation of cell communication cellular response to stress regulation of response to stress regulation of signal transduction by p53 class mediator negative regulation of DNA damage response, signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of signal transduction by p53 class mediator negative regulation of response to stimulus signal transduction by p53 class mediator negative regulation of signal transduction DNA damage response signal transduction in response to DNA damage regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response response to external stimulus regulation of inflammatory response negative regulation of response to external stimulus negative regulation of defense response regulation of developmental process plasma membrane bounded cell projection morphogenesis cell morphogenesis regulation of cell morphogenesis cell projection morphogenesis regulation of lamellipodium organization regulation of lamellipodium morphogenesis regulation of anatomical structure morphogenesis regulation of cell projection organization lamellipodium organization lamellipodium morphogenesis regulation of plasma membrane bounded cell projection organization regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator negative regulation of apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway by p53 class mediator regulation of apoptotic signaling pathway regulation of intrinsic apoptotic signaling pathway intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator regulation of intrinsic apoptotic signaling pathway by p53 class mediator prostate gland development reproductive process gland development developmental process involved in reproduction prostate gland epithelium morphogenesis gland morphogenesis reproductive structure development reproductive system development urogenital system development prostate gland morphogenesis branching involved in prostate gland morphogenesis Wnt signaling pathway negative regulation of lymphocyte proliferation regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation negative regulation of T cell proliferation negative regulation of cell adhesion negative regulation of leukocyte proliferation alpha-beta T cell proliferation T cell activation lymphocyte proliferation alpha-beta T cell activation regulation of leukocyte proliferation cell population proliferation regulation of CD4-positive, alpha-beta T cell proliferation negative regulation of CD4-positive, alpha-beta T cell activation negative regulation of T cell activation negative regulation of leukocyte cell-cell adhesion mononuclear cell proliferation regulation of cell population proliferation negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation lymphocyte activation negative regulation of lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation negative regulation of mononuclear cell proliferation regulation of alpha-beta T cell proliferation cell-cell adhesion CD4-positive, alpha-beta T cell activation regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation CD4-positive, alpha-beta T cell proliferation negative regulation of cell population proliferation regulation of cell adhesion cell activation regulation of T cell activation negative regulation of cell activation regulation of T cell proliferation negative regulation of alpha-beta T cell proliferation regulation of CD4-positive, alpha-beta T cell activation negative regulation of immune system process negative regulation of CD4-positive, alpha-beta T cell proliferation regulation of mononuclear cell proliferation negative regulation of alpha-beta T cell activation regulation of lymphocyte activation epiboly involved in wound healing morphogenesis of an epithelial sheet epiboly wound healing, spreading of cells regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation regulation of cell development negative regulation of T cell differentiation T cell differentiation negative regulation of hemopoiesis negative regulation of leukocyte differentiation negative regulation of lymphocyte differentiation leukocyte differentiation regulation of T cell differentiation negative regulation of regulatory T cell differentiation negative regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis negative regulation of developmental process regulation of regulatory T cell differentiation negative regulation of cell development regulatory T cell differentiation regulation of hemopoiesis peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane cell projection actin-based cell projection microvillus cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane basal part of cell basal plasma membrane plasma membrane region basolateral plasma membrane cell projection actin-based cell projection microvillus plasma membrane bounded cell projection apical part of cell apical plasma membrane membrane microdomain membrane raft protein-containing complex macrophage migration inhibitory factor receptor complex receptor complex cell leading edge leading edge membrane lamellipodium membrane cell projection membrane lamellipodium extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016187	C-type lectin fold	Homologous Superfamily
A	IPR043210	CD44 antigen-like	Family
A	IPR001231	CD44 antigen	Family
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR000538	Link domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.