4NYJ

Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth R]	d4nyjr_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	cH-p21 Ras protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth S]	d4nyjs_	All alpha proteins	Ras GEF	Ras GEF	Ras GEF	Son of sevenless protein homolog 1 (sos-1)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A [auth Q]	d4nyjq_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	cH-p21 Ras protein	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth R]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019405	3002022	SCOP2B (2022-06-29)
C [auth S]	SCOP2B Superfamily	ENTH/VHS domain-like	8057961	3000164	SCOP2B (2022-06-29)
C [auth S]	SCOP2B Superfamily	Ras GEF	8057967	3000128	SCOP2B (2022-06-29)
A [auth Q]	SCOP2B Superfamily	Ras-like P-loop GTPases	8019405	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth R]	Ras	e4nyjR1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
C [auth S]	RasGEF	e4nyjS1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Ras GEF (From Topology)	T: Ras GEF	F: RasGEF	ECOD (1.6)
A [auth Q]	Ras	e4nyjQ1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth R]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
C [auth S]	1.20.870.10	Mainly Alpha	Up-down Bundle	Son of sevenless (SoS) protein	Chain S, domain 1	CATH (4.3.0)
C [auth S]	1.10.840.10	Mainly Alpha	Orthogonal Bundle	Son of Sevenless (SoS) protein	Chain S, domain 2	CATH (4.3.0)
A [auth Q]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth R]	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain
C [auth S]	PF00617	RasGEF domain (RasGEF)	RasGEF domain	-	Family
C [auth S]	PF00618	RasGEF N-terminal motif (RasGEF_N)	RasGEF N-terminal motif	A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.	Domain
A [auth Q]	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B [auth R]	GTPase HRas	pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity enzyme regulator activity enzyme activator activity phospholipase C activator activity molecular function activator activity phospholipase activator activity molecular function regulator activity lipase activator activity pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity enzyme regulator activity enzyme activator activity phospholipase C activator activity molecular function activator activity phospholipase activator activity molecular function regulator activity lipase activator activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GDP binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity G protein activity	positive regulation of response to wounding wound healing regulation of biological process response to stimulus biological regulation positive regulation of biological process regulation of response to wounding positive regulation of response to stimulus positive regulation of wound healing regulation of response to stimulus response to stress regulation of response to stress regulation of wound healing response to wounding positive regulation of response to wounding wound healing regulation of biological process response to stimulus biological regulation positive regulation of biological process regulation of response to wounding positive regulation of response to stimulus positive regulation of wound healing regulation of response to stimulus response to stress regulation of response to stress regulation of wound healing response to wounding regulation of cellular process RNA metabolic process positive regulation of miRNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of RNA metabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cellular response to stimulus cellular response to stress cellular senescence negative regulation of hydrolase activity negative regulation of GTPase activity regulation of catalytic activity negative regulation of molecular function negative regulation of biological process negative regulation of catalytic activity regulation of GTPase activity regulation of molecular function regulation of hydrolase activity signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction chemotaxis taxis response to chemical response to external stimulus locomotion regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of signaling regulation of long-term neuronal synaptic plasticity modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of biological quality positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of signaling biological process involved in interspecies interaction between organisms response to other organism defense response defense response to protozoan response to biotic stimulus response to protozoan defense response to other organism response to external biotic stimulus fibroblast proliferation cell population proliferation positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription transcription by RNA polymerase II positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription protein localization regulation of localization cellular localization establishment of protein localization regulation of protein localization protein targeting positive regulation of establishment of protein localization localization regulation of protein targeting to membrane cellular macromolecule localization regulation of protein localization to membrane establishment of protein localization to membrane regulation of establishment of protein localization positive regulation of protein localization to membrane localization within membrane protein localization to membrane establishment of localization protein targeting to membrane regulation of cellular localization regulation of protein targeting macromolecule localization positive regulation of protein localization positive regulation of protein targeting to membrane regulation of cellular component organization positive regulation of cellular component organization cell projection organization ruffle organization plasma membrane bounded cell projection assembly ruffle assembly cellular component biogenesis cellular component organization cellular component assembly positive regulation of cell projection organization cellular component organization or biogenesis plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis positive regulation of ruffle assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly developmental process connective tissue development adipose tissue development animal organ development anatomical structure development tissue development immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response anatomical structure morphogenesis animal organ morphogenesis positive regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cell death apoptotic signaling pathway apoptotic process intrinsic apoptotic signaling pathway programmed cell death cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus response to gamma radiation import into cell transport endocytosis vesicle-mediated transport regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation positive regulation of molecular function positive regulation of hydrolase activity positive regulation of catalytic activity positive regulation of GTPase activity multicellular organismal process cellular developmental process peripheral nervous system development cell development nervous system development glial cell development multicellular organism development neurogenesis Schwann cell development gliogenesis glial cell differentiation cell differentiation Schwann cell differentiation system development positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process regulation of neuron apoptotic process small GTPase-mediated signal transduction Ras protein signal transduction positive regulation of phosphorylation regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation protein localization to synapse regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane regulation of protein localization to cell periphery protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse oncogene-induced cell senescence cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to insulin cellular response to insulin stimulus negative regulation of cell population proliferation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T-helper 1 type immune response adaptive immune response myelination axon ensheathment ensheathment of neurons cell cycle regulation of cell cycle negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process regulation of type II interferon production type II interferon production cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of type II interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system Golgi membrane cellular anatomical structure intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane perinuclear region of cytoplasm cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane protein-containing complex catalytic complex GTPase complex
C [auth S]	Son of sevenless homolog 1	GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity SH3 domain binding protein binding binding protein domain specific binding protein heterodimerization activity protein dimerization activity molecular condensate scaffold activity GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity SH3 domain binding protein binding binding protein domain specific binding protein heterodimerization activity protein dimerization activity molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding signaling receptor binding growth factor receptor binding	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus cellular process signal transduction multicellular organismal process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation T cell activation lymphocyte proliferation regulation of multicellular organismal process regulation of immune system process T cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation cell activation regulation of T cell activation regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation response to stress response to ischemia cellular component organization sexual reproduction reproductive process multicellular organismal reproductive process cytoplasm organization cellular component organization or biogenesis female gamete generation vitellogenesis gamete generation B cell homeostasis multicellular organismal-level homeostasis leukocyte homeostasis homeostatic process homeostasis of number of cells lymphocyte homeostasis insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction positive regulation of response to stimulus positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of cellular process positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway regulation of signaling regulation of response to stimulus ERBB signaling pathway regulation of cell communication positive regulation of signaling immune response-regulating cell surface receptor signaling pathway immune response Fc receptor signaling pathway immune response-regulating signaling pathway Fc-epsilon receptor signaling pathway regulation of immune response developmental process head development brain morphogenesis animal organ development brain development nervous system development midbrain morphogenesis multicellular organism development anatomical structure morphogenesis central nervous system development midbrain development anatomical structure development animal organ morphogenesis system development regulation of pro-B cell differentiation regulation of developmental process cellular developmental process hemopoiesis cell development regulation of cell differentiation regulation of lymphoid progenitor cell differentiation pro-B cell differentiation cell differentiation lymphoid progenitor cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation multicellular organism growth developmental growth growth pericardium morphogenesis heart development epithelium development embryonic morphogenesis morphogenesis of an epithelium embryo development tissue development morphogenesis of an epithelial sheet circulatory system development tissue morphogenesis pericardium development blood vessel morphogenesis tube development vasculature development tube morphogenesis blood vessel development cardiac atrium morphogenesis cardiac chamber morphogenesis heart morphogenesis cardiac atrium development cardiac chamber development immune response-activating signaling pathway positive regulation of immune response positive regulation of immune system process immune response-activating cell surface receptor signaling pathway B cell receptor signaling pathway antigen receptor-mediated signaling pathway activation of immune response heart trabecula morphogenesis trabecula morphogenesis peripheral nervous system development glial cell development neurogenesis Schwann cell development gliogenesis glial cell differentiation Schwann cell differentiation epidermis development molting cycle process hair cycle skin development skin epidermis development hair follicle development molting cycle hair cycle process small GTPase-mediated signal transduction Ras protein signal transduction intracellular signal transduction intracellular signaling cassette response to fibroblast growth factor cellular response to growth factor stimulus response to endogenous stimulus cellular response to endogenous stimulus fibroblast growth factor receptor signaling pathway response to growth factor cellular response to fibroblast growth factor stimulus cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway response to hormone cellular response to hormone stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to insulin cellular response to insulin stimulus axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis plasma membrane bounded cell projection organization axon guidance axon development cell morphogenesis involved in neuron differentiation generation of neurons neuron projection guidance neuron development leukocyte migration cell migration cell motility regulation of leukocyte differentiation regulation of T cell differentiation in thymus mononuclear cell differentiation lymphocyte differentiation regulation of cell development regulation of T cell differentiation T cell differentiation in thymus T cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of hemopoiesis leukocyte differentiation neurotrophin TRK receptor signaling pathway neurotrophin signaling pathway myelination axon ensheathment ensheathment of neurons RNA metabolic process regulation of primary metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process eyelid development in camera-type eye sensory organ development eye development visual system development camera-type eye development sensory system development regulation of small GTPase mediated signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction positive regulation of small GTPase mediated signal transduction roof of mouth development	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell body neuronal cell body cell periphery plasma membrane membrane protein-containing complex catalytic complex GTPase complex
A [auth Q]	GTPase HRas	pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity enzyme regulator activity enzyme activator activity phospholipase C activator activity molecular function activator activity phospholipase activator activity molecular function regulator activity lipase activator activity pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity enzyme regulator activity enzyme activator activity phospholipase C activator activity molecular function activator activity phospholipase activator activity molecular function regulator activity lipase activator activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GDP binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity G protein activity	positive regulation of response to wounding wound healing regulation of biological process response to stimulus biological regulation positive regulation of biological process regulation of response to wounding positive regulation of response to stimulus positive regulation of wound healing regulation of response to stimulus response to stress regulation of response to stress regulation of wound healing response to wounding positive regulation of response to wounding wound healing regulation of biological process response to stimulus biological regulation positive regulation of biological process regulation of response to wounding positive regulation of response to stimulus positive regulation of wound healing regulation of response to stimulus response to stress regulation of response to stress regulation of wound healing response to wounding regulation of cellular process RNA metabolic process positive regulation of miRNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process primary metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of RNA metabolic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process cellular response to stimulus cellular response to stress cellular senescence negative regulation of hydrolase activity negative regulation of GTPase activity regulation of catalytic activity negative regulation of molecular function negative regulation of biological process negative regulation of catalytic activity regulation of GTPase activity regulation of molecular function regulation of hydrolase activity signaling intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction chemotaxis taxis response to chemical response to external stimulus locomotion regulation of neuronal synaptic plasticity regulation of synaptic plasticity trans-synaptic signaling regulation of signaling regulation of long-term neuronal synaptic plasticity modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication regulation of biological quality positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of signaling biological process involved in interspecies interaction between organisms response to other organism defense response defense response to protozoan response to biotic stimulus response to protozoan defense response to other organism response to external biotic stimulus fibroblast proliferation cell population proliferation positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription transcription by RNA polymerase II positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription protein localization regulation of localization cellular localization establishment of protein localization regulation of protein localization protein targeting positive regulation of establishment of protein localization localization regulation of protein targeting to membrane cellular macromolecule localization regulation of protein localization to membrane establishment of protein localization to membrane regulation of establishment of protein localization positive regulation of protein localization to membrane localization within membrane protein localization to membrane establishment of localization protein targeting to membrane regulation of cellular localization regulation of protein targeting macromolecule localization positive regulation of protein localization positive regulation of protein targeting to membrane regulation of cellular component organization positive regulation of cellular component organization cell projection organization ruffle organization plasma membrane bounded cell projection assembly ruffle assembly cellular component biogenesis cellular component organization cellular component assembly positive regulation of cell projection organization cellular component organization or biogenesis plasma membrane bounded cell projection organization positive regulation of cellular component biogenesis regulation of cell projection organization regulation of cell projection assembly regulation of cellular component biogenesis positive regulation of ruffle assembly regulation of plasma membrane bounded cell projection assembly regulation of ruffle assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly developmental process connective tissue development adipose tissue development animal organ development anatomical structure development tissue development immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response anatomical structure morphogenesis animal organ morphogenesis positive regulation of ERK1 and ERK2 cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cell death apoptotic signaling pathway apoptotic process intrinsic apoptotic signaling pathway programmed cell death cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus response to ionizing radiation cellular response to gamma radiation response to radiation response to abiotic stimulus cellular response to abiotic stimulus response to gamma radiation import into cell transport endocytosis vesicle-mediated transport regulation of cytoskeleton organization regulation of actin filament-based process actin cytoskeleton organization regulation of organelle organization organelle organization regulation of actin cytoskeleton organization actin filament-based process cytoskeleton organization positive regulation of cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation positive regulation of fibroblast proliferation positive regulation of molecular function positive regulation of hydrolase activity positive regulation of catalytic activity positive regulation of GTPase activity multicellular organismal process cellular developmental process peripheral nervous system development cell development nervous system development glial cell development multicellular organism development neurogenesis Schwann cell development gliogenesis glial cell differentiation cell differentiation Schwann cell differentiation system development positive regulation of epithelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process regulation of neuron apoptotic process small GTPase-mediated signal transduction Ras protein signal transduction positive regulation of phosphorylation regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation protein localization to synapse regulation of neurotransmitter receptor localization to postsynaptic specialization membrane regulation of protein localization to synapse neurotransmitter receptor localization to postsynaptic specialization membrane regulation of receptor localization to synapse protein localization to postsynaptic specialization membrane protein localization to cell periphery protein localization to postsynaptic membrane regulation of protein localization to cell periphery protein-containing complex localization regulation of postsynaptic membrane neurotransmitter receptor levels protein localization to organelle protein localization to postsynapse protein localization to cell junction receptor localization to synapse oncogene-induced cell senescence cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus response to endogenous stimulus response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to insulin cellular response to insulin stimulus negative regulation of cell population proliferation positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T-helper 1 type immune response adaptive immune response myelination axon ensheathment ensheathment of neurons cell cycle regulation of cell cycle negative regulation of metabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of macromolecule metabolic process regulation of type II interferon production type II interferon production cytokine production regulation of cytokine production regulation of multicellular organismal process positive regulation of type II interferon production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system Golgi membrane cellular anatomical structure intracellular anatomical structure cytoplasm cytosol synapse cell junction glutamatergic synapse membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane perinuclear region of cytoplasm cell periphery plasma membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane protein-containing complex catalytic complex GTPase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth R]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth R]	IPR020849	Small GTPase, Ras-type	Family
B [auth R]	IPR005225	Small GTP-binding domain	Domain
B [auth R]	IPR001806	Small GTPase	Family
C [auth S]	IPR000219	Dbl homology (DH) domain	Domain
C [auth S]	IPR008937	Ras-like guanine nucleotide exchange factor	Family
C [auth S]	IPR019804	Ras guanine-nucleotide exchange factor, conserved site	Conserved Site
C [auth S]	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Homologous Superfamily
C [auth S]	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
C [auth S]	IPR023578	Ras guanine nucleotide exchange factor domain superfamily	Homologous Superfamily
C [auth S]	IPR001849	Pleckstrin homology domain	Domain
C [auth S]	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal	Domain
C [auth S]	IPR011993	PH-like domain superfamily	Homologous Superfamily
C [auth S]	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain	Domain
C [auth S]	IPR009072	Histone-fold	Homologous Superfamily
A [auth Q]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth Q]	IPR020849	Small GTPase, Ras-type	Family
A [auth Q]	IPR005225	Small GTP-binding domain	Domain
A [auth Q]	IPR001806	Small GTPase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth R]	Pharos: P01112	Costello syndrome urinary bladder cancer thyroid cancer, nonmedullary, 2 cardiofaciocutaneous syndrome Noonan syndrome cancer transitional cell carcinoma large congenital melanocytic nevus seminoma squamous cell carcinoma hepatocellular adenoma angiosarcoma neuroblastoma nevus, epidermal penile neoplasm Costello syndrome urinary bladder cancer thyroid cancer, nonmedullary, 2 cardiofaciocutaneous syndrome Noonan syndrome cancer transitional cell carcinoma large congenital melanocytic nevus seminoma squamous cell carcinoma hepatocellular adenoma angiosarcoma neuroblastoma nevus, epidermal penile neoplasm sarcomatoid carcinoma breast carcinoma carcinoma thyroid gland carcinoma Mammary Neoplasms, Experimental salivary gland adenoid cystic carcinoma liver cancer skin neoplasm prostate cancer linear nevus sebaceus syndrome adenoid cystic carcinoma skin cancer squamous papilloma testicular seminoma papilloma head and neck squamous cell carcinoma thyroid adenoma hepatocellular carcinoma mammary neoplasms, animal hereditary diffuse gastric adenocarcinoma melanoma cervical carcinoma prostate disease hypertrophic cardiomyopathy myositis intellectual disability urothelial carcinoma connective tissue disease rheumatoid arthritis acute myeloid leukemia uterine disease cutaneous melanoma liver neoplasm adenoma skin disease lung benign neoplasm epidermal nevus syndrome bladder carcinoma in situ systemic lupus erythematosus ovarian cancer gastric cancer thymic carcinoma papillomatosis hematologic disease thyroid cancer phakomatosis pigmentokeratotica Hutchinson-Gilford progeria syndrome tongue cancer Charcot-Marie-Tooth disease hypothyroidism urinary bladder carcinoma congenital anemia verrucous nevus astrocytic tumor lung cancer lymphatic system disease brain cancer oral cavity neoplasm systemic sclerosis breast adenocarcinoma ovarian disease gastric neoplasm thymus neoplasm breast disease penile cancer precancerous condition thyroid gland papillary carcinoma cerebral cortical dysplasia hydrops fetalis colorectal adenocarcinoma inflammatory linear verrucous epidermal nevus undifferentiated carcinoma urinary bladder neoplasm rhabdomyosarcoma uterine cervix carcinoma in situ sarcoma woolly hair nevus digestive system disease lung adenocarcinoma autism endometriosis spleen cancer lung disease bladder benign neoplasm breast cancer
C [auth S]	Pharos: Q07889	Noonan syndrome Noonan syndrome 4 hereditary gingival fibromatosis fibromatosis, gingival, 1 pancreatic ductal adenocarcinoma Adenocarcinoma of Lung Costello syndrome hepatocellular carcinoma hypertrophic cardiomyopathy malignant pancreatic neoplasm osteosarcoma tuberculosis cardiofaciocutaneous syndrome intellectual disability medulloblastoma Noonan syndrome Noonan syndrome 4 hereditary gingival fibromatosis fibromatosis, gingival, 1 pancreatic ductal adenocarcinoma Adenocarcinoma of Lung Costello syndrome hepatocellular carcinoma hypertrophic cardiomyopathy malignant pancreatic neoplasm osteosarcoma tuberculosis cardiofaciocutaneous syndrome intellectual disability medulloblastoma Noonan syndrome with multiple lentigines ovarian cancer Charcot-Marie-Tooth disease hydrops fetalis lung adenocarcinoma osteogenesis imperfecta
A [auth Q]	Pharos: P01112	Costello syndrome urinary bladder cancer thyroid cancer, nonmedullary, 2 cardiofaciocutaneous syndrome Noonan syndrome cancer transitional cell carcinoma large congenital melanocytic nevus seminoma squamous cell carcinoma hepatocellular adenoma angiosarcoma neuroblastoma nevus, epidermal penile neoplasm Costello syndrome urinary bladder cancer thyroid cancer, nonmedullary, 2 cardiofaciocutaneous syndrome Noonan syndrome cancer transitional cell carcinoma large congenital melanocytic nevus seminoma squamous cell carcinoma hepatocellular adenoma angiosarcoma neuroblastoma nevus, epidermal penile neoplasm sarcomatoid carcinoma breast carcinoma carcinoma thyroid gland carcinoma Mammary Neoplasms, Experimental salivary gland adenoid cystic carcinoma liver cancer skin neoplasm prostate cancer linear nevus sebaceus syndrome adenoid cystic carcinoma skin cancer squamous papilloma testicular seminoma papilloma head and neck squamous cell carcinoma thyroid adenoma hepatocellular carcinoma mammary neoplasms, animal hereditary diffuse gastric adenocarcinoma melanoma cervical carcinoma prostate disease hypertrophic cardiomyopathy myositis intellectual disability urothelial carcinoma connective tissue disease rheumatoid arthritis acute myeloid leukemia uterine disease cutaneous melanoma liver neoplasm adenoma skin disease lung benign neoplasm epidermal nevus syndrome bladder carcinoma in situ systemic lupus erythematosus ovarian cancer gastric cancer thymic carcinoma papillomatosis hematologic disease thyroid cancer phakomatosis pigmentokeratotica Hutchinson-Gilford progeria syndrome tongue cancer Charcot-Marie-Tooth disease hypothyroidism urinary bladder carcinoma congenital anemia verrucous nevus astrocytic tumor lung cancer lymphatic system disease brain cancer oral cavity neoplasm systemic sclerosis breast adenocarcinoma ovarian disease gastric neoplasm thymus neoplasm breast disease penile cancer precancerous condition thyroid gland papillary carcinoma cerebral cortical dysplasia hydrops fetalis colorectal adenocarcinoma inflammatory linear verrucous epidermal nevus undifferentiated carcinoma urinary bladder neoplasm rhabdomyosarcoma uterine cervix carcinoma in situ sarcoma woolly hair nevus digestive system disease lung adenocarcinoma autism endometriosis spleen cancer lung disease bladder benign neoplasm breast cancer

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