Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATrm112pe4qtuA1 A: few secondary structure elementsX: Trm112p-like (From Topology)H: Trm112p-like (From Topology)T: Trm112p-likeF: Trm112pECOD (1.6)
CTrm112pe4qtuC1 A: few secondary structure elementsX: Trm112p-like (From Topology)H: Trm112p-like (From Topology)T: Trm112p-likeF: Trm112pECOD (1.6)
BMethyltransf_11_1e4qtuB1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_1ECOD (1.6)
DMethyltransf_11_1e4qtuD1 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: S-adenosyl-L-methionine-dependent methyltransferasesF: Methyltransf_11_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.20.25.10 Mainly Beta Single Sheet N-terminal domain of TfIIb CATH (4.3.0)
C2.20.25.10 Mainly Beta Single Sheet N-terminal domain of TfIIb CATH (4.3.0)
B3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)
D3.40.50.150 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Vaccinia Virus protein VP39CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C
PF03966Trm112p-like protein (Trm112p)Trm112p-like proteinThe function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA ...The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W [1]. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast [2]. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices [2].
Domain
B, D
PF08241Methyltransferase domain (Methyltransf_11)Methyltransferase domainMembers of this family are SAM dependent methyltransferases.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C
Multifunctional methyltransferase subunit TRM112
B, D
Putative methyltransferase BUD23

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
B, D
CSO Parent Component: CYS

RESIDAA0205

PSI-MOD :  L-cysteine sulfenic acid MOD:00210