Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AE1-E2_ATPase_N,ATPase-IIC_X-Ke4resA2 A: beta sandwichesX: jelly-rollH: Calcium ATPase, transduction domain A (From Topology)T: Calcium ATPase, transduction domain AF: E1-E2_ATPase_N,ATPase-IIC_X-KECOD (1.6)
ACation_ATPase_Ce4resA3 A: alpha bundlesX: Calcium ATPase transmembrane domain-related (From Homology)H: Calcium ATPase transmembrane domain-relatedT: Calcium ATPase transmembrane domain MF: Cation_ATPase_CECOD (1.6)
ACation_ATPasee4resA1 A: a+b complex topologyX: Metal cation-transporting ATPase, ATP-binding domain (From Topology)H: Metal cation-transporting ATPase, ATP-binding domain (From Topology)T: Metal cation-transporting ATPase, ATP-binding domainF: Cation_ATPaseECOD (1.6)
AHydrolase_3_1e4resA4 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: HAD-likeF: Hydrolase_3_1ECOD (1.6)
D [auth C]E1-E2_ATPase_N,ATPase-IIC_X-Ke4resC3 A: beta sandwichesX: jelly-rollH: Calcium ATPase, transduction domain A (From Topology)T: Calcium ATPase, transduction domain AF: E1-E2_ATPase_N,ATPase-IIC_X-KECOD (1.6)
D [auth C]Cation_ATPase_Ce4resC1 A: alpha bundlesX: Calcium ATPase transmembrane domain-related (From Homology)H: Calcium ATPase transmembrane domain-relatedT: Calcium ATPase transmembrane domain MF: Cation_ATPase_CECOD (1.6)
D [auth C]Cation_ATPasee4resC4 A: a+b complex topologyX: Metal cation-transporting ATPase, ATP-binding domain (From Topology)H: Metal cation-transporting ATPase, ATP-binding domain (From Topology)T: Metal cation-transporting ATPase, ATP-binding domainF: Cation_ATPaseECOD (1.6)
D [auth C]Hydrolase_3_1e4resC2 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: HAD-likeF: Hydrolase_3_1ECOD (1.6)
BNa_K-ATPase_Ce4resB2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Na_K-ATPase_CECOD (1.6)
BNa_K-ATPase_Ne4resB1 A: extended segmentsX: Transmembrane helix in sodium-potassium ATPase beta subunit (From Topology)H: Transmembrane helix in sodium-potassium ATPase beta subunit (From Topology)T: Transmembrane helix in sodium-potassium ATPase beta subunitF: Na_K-ATPase_NECOD (1.6)
E [auth D]Na_K-ATPase_Ce4resD1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Na_K-ATPase_CECOD (1.6)
E [auth D]Na_K-ATPase_Ne4resD2 A: extended segmentsX: Transmembrane helix in sodium-potassium ATPase beta subunit (From Topology)H: Transmembrane helix in sodium-potassium ATPase beta subunit (From Topology)T: Transmembrane helix in sodium-potassium ATPase beta subunitF: Na_K-ATPase_NECOD (1.6)
F [auth E]ATP1G1_PLM_MAT8e4resE1 A: extended segmentsX: FXYD family (From Topology)H: FXYD family (From Topology)T: FXYD familyF: ATP1G1_PLM_MAT8ECOD (1.6)
C [auth G]ATP1G1_PLM_MAT8e4resG1 A: extended segmentsX: FXYD family (From Topology)H: FXYD family (From Topology)T: FXYD familyF: ATP1G1_PLM_MAT8ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.70.150.10 Mainly Beta Distorted Sandwich Calcium-transporting ATPase, cytoplasmic transduction domain A Calcium-transporting ATPase, cytoplasmic transduction domain ACATH (4.3.0)
A1.20.1110.10 Mainly Alpha Up-down Bundle Calcium-transporting ATPase, transmembrane domain Calcium-transporting ATPase, transmembrane domainCATH (4.3.0)
A3.40.50.1000 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold HAD superfamily/HAD-likeCATH (4.3.0)
A3.40.1110.10 Alpha Beta 3-Layer(aba) Sandwich Calcium-transporting ATPase, cytoplasmic domain N Calcium-transporting ATPase, cytoplasmic domain NCATH (4.3.0)
D [auth C]2.70.150.10 Mainly Beta Distorted Sandwich Calcium-transporting ATPase, cytoplasmic transduction domain A Calcium-transporting ATPase, cytoplasmic transduction domain ACATH (4.3.0)
D [auth C]1.20.1110.10 Mainly Alpha Up-down Bundle Calcium-transporting ATPase, transmembrane domain Calcium-transporting ATPase, transmembrane domainCATH (4.3.0)
D [auth C]3.40.50.1000 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold HAD superfamily/HAD-likeCATH (4.3.0)
D [auth C]3.40.1110.10 Alpha Beta 3-Layer(aba) Sandwich Calcium-transporting ATPase, cytoplasmic domain N Calcium-transporting ATPase, cytoplasmic domain NCATH (4.3.0)
B1.20.5.170 Mainly Alpha Up-down Bundle Single alpha-helices involved in coiled-coils or other helix-helix interfaces CATH (4.3.0)
B2.60.40.1660 Mainly Beta Sandwich Immunoglobulin-like Na, k-atpase alpha subunit.CATH (4.3.0)
E [auth D]1.20.5.170 Mainly Alpha Up-down Bundle Single alpha-helices involved in coiled-coils or other helix-helix interfaces CATH (4.3.0)
E [auth D]2.60.40.1660 Mainly Beta Sandwich Immunoglobulin-like Na, k-atpase alpha subunit.CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
D [auth C]
PF00689Cation transporting ATPase, C-terminus (Cation_ATPase_C)Cation transporting ATPase, C-terminus- Family
A,
D [auth C]
PF00702haloacid dehalogenase-like hydrolase (Hydrolase)haloacid dehalogenase-like hydrolaseThis family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted fo ...This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2].
Domain
A,
D [auth C]
PF00690Cation transporter/ATPase, N-terminus (Cation_ATPase_N)Cation transporter/ATPase, N-terminusMembers of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.Domain
A,
D [auth C]
PF00122E1-E2 ATPase (E1-E2_ATPase)E1-E2 ATPase- Family
A,
D [auth C]
PF13246Cation transport ATPase (P-type) (Cation_ATPase)Cation transport ATPase (P-type)- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
D [auth C]
Sodium/potassium-transporting ATPase subunit alpha-1
B,
E [auth D]
Sodium/potassium-transporting ATPase subunit beta-1
C [auth G],
F [auth E]
Na+/K+ ATPase gamma subunit transcript variant a

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
A,
D [auth C]
PHD Parent Component: ASP

RESIDAA0033

PSI-MOD :  L-aspartic 4-phosphoric anhydride MOD:00042