4TLG

Crystal structure of SEC14-like protein 4 (SEC14L4)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4tlga1	All alpha proteins	RuvA C-terminal domain-like	CRAL/TRIO N-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4tlga3	All beta proteins	Supernatant protein factor (SPF), C-terminal domain	Supernatant protein factor (SPF), C-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d4tlga2	Alpha and beta proteins (a/b)	SpoIIaa-like	CRAL/TRIO domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4tlgb1	All alpha proteins	RuvA C-terminal domain-like	CRAL/TRIO N-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4tlgb3	All beta proteins	Supernatant protein factor (SPF), C-terminal domain	Supernatant protein factor (SPF), C-terminal domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4tlgb2	Alpha and beta proteins (a/b)	SpoIIaa-like	CRAL/TRIO domain	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GOLD_2	e4tlgA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: GOLD_2	ECOD (1.6)
A	CRAL_TRIO_N	e4tlgA2	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: CRAL_TRIO_N	ECOD (1.6)
A	CRAL_TRIO	e4tlgA3	A: a/b three-layered sandwiches	X: SpoIIaa-like (From Topology)	H: SpoIIaa-like (From Topology)	T: SpoIIaa-like	F: CRAL_TRIO	ECOD (1.6)
B	GOLD_2	e4tlgB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: GOLD_2	ECOD (1.6)
B	CRAL_TRIO_N	e4tlgB2	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: CRAL_TRIO_N	ECOD (1.6)
B	CRAL_TRIO	e4tlgB3	A: a/b three-layered sandwiches	X: SpoIIaa-like (From Topology)	H: SpoIIaa-like (From Topology)	T: SpoIIaa-like	F: CRAL_TRIO	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.525.10	Alpha Beta	3-Layer(aba) Sandwich	Phosphatidylinositol Transfer Protein Sec14p	CRAL-TRIO lipid binding domain	CATH (4.3.0)
A	2.60.120.680	Mainly Beta	Sandwich	Jelly Rolls	GOLD domain	CATH (4.3.0)
B	3.40.525.10	Alpha Beta	3-Layer(aba) Sandwich	Phosphatidylinositol Transfer Protein Sec14p	CRAL-TRIO lipid binding domain	CATH (4.3.0)
B	2.60.120.680	Mainly Beta	Sandwich	Jelly Rolls	GOLD domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00650	CRAL/TRIO domain (CRAL_TRIO)	CRAL/TRIO domain	-	Domain
A, B	PF03765	CRAL/TRIO, N-terminal domain (CRAL_TRIO_N)	CRAL/TRIO, N-terminal domain	This all-alpha domain is found to the N-terminus of Pfam:PF00650.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	SEC14-like protein 4	binding lipid binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR001251	CRAL-TRIO lipid binding domain	Domain
A, B	IPR011074	CRAL/TRIO, N-terminal domain	Domain
A, B	IPR036598	GOLD domain superfamily	Homologous Superfamily
A, B	IPR051064	SEC14-like and CRAL-TRIO domain-containing protein	Family
A, B	IPR009038	GOLD domain	Domain
A, B	IPR036865	CRAL-TRIO lipid binding domain superfamily	Homologous Superfamily
A, B	IPR036273	CRAL/TRIO, N-terminal domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9UDX3	Creutzfeldt Jacob disease MALT lymphoma pancreatic ductal adenocarcinoma lung adenocarcinoma non-small cell lung carcinoma psoriasis lung carcinoma osteosarcoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.