Annotations: 4TND

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RGS	e4tndA2	A: alpha bundles	X: Regulator of G-protein signaling, RGS (From Topology)	H: Regulator of G-protein signaling, RGS (From Topology)	T: Regulator of G-protein signaling, RGS	F: RGS	ECOD (1.6)
A	Pkinase_Tyr	e4tndA1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.167.10	Mainly Alpha	Orthogonal Bundle	Regulator of G-protein Signalling 4	domain 2	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00615	Regulator of G protein signaling domain (RGS)	Regulator of G protein signaling domain	RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.	Domain
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	G protein-coupled receptor kinase 5	catalytic activity, acting on a protein beta-adrenergic receptor kinase activity kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding phospholipid binding lipid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding catalytic activity, acting on a protein beta-adrenergic receptor kinase activity kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding phospholipid binding lipid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity protein binding kinase binding protein kinase C binding enzyme binding protein kinase binding G protein-coupled receptor kinase activity	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular response to stimulus regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular response to stimulus regulation of signaling response to stimulus signaling regulation of signal transduction cell communication regulation of response to stimulus regulation of cell communication signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway protein phosphorylation protein autophosphorylation phosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of biological process positive regulation of cellular process regulation of G protein-coupled receptor signaling pathway developmental process fat cell differentiation cellular developmental process cell differentiation tachykinin receptor signaling pathway cell surface receptor signaling pathway Wnt signaling pathway cell cycle regulation of cell cycle	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane cytoplasm cytosol cell periphery plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016137	RGS domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR036305	RGS domain superfamily	Homologous Superfamily
A	IPR000719	Protein kinase domain	Domain
A	IPR000961	AGC-kinase, C-terminal	Domain
A	IPR044926	RGS, subdomain 2	Homologous Superfamily
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR000239	GPCR kinase	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P34947	cardiovascular disease liver disease malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis adenoma adrenoleukodystrophy breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma Liver Dysfunction lung carcinoma malignant mesothelioma osteosarcoma cardiovascular disease liver disease malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis adenoma adrenoleukodystrophy breast carcinoma ductal breast carcinoma in situ invasive ductal breast carcinoma Liver Dysfunction lung carcinoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia vascular disease adrenal cortex adenoma astrocytic tumor esophageal adenocarcinoma large cell medulloblastoma lung adenocarcinoma major depressive disorder maturity-onset diabetes of the young ovarian cancer type 2 diabetes mellitus adrenal cortex carcinoma Barrett esophagus dermatomyositis interstitial cystitis lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.