4TWK

Crystal structure of human two pore domain potassium ion channel TREK1 (K2P2.1)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Ion_trans_2_1	e4twkB1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
B	Ion_trans_2	e4twkB2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)
A	Ion_trans_2_1	e4twkA1	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2_1	ECOD (1.6)
A	Ion_trans_2	e4twkA2	A: alpha complex topology	X: Voltage-gated ion channels (From Topology)	H: Voltage-gated ion channels (From Topology)	T: Voltage-gated ion channels	F: Ion_trans_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)
A	1.10.287.70	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07885	Ion channel (Ion_trans_2)	Ion channel	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Potassium channel subfamily K member 2	molecular function inhibitor activity potassium channel regulator activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity potassium channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity molecular function inhibitor activity potassium channel regulator activity channel regulator activity transporter inhibitor activity ion channel inhibitor activity ion channel regulator activity potassium channel inhibitor activity molecular function regulator activity transporter regulator activity channel inhibitor activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity narrow pore channel activity leak channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity gated channel activity outward rectifier potassium channel activity voltage-gated channel activity voltage-gated monoatomic ion channel activity voltage-gated monoatomic cation channel activity voltage-gated potassium channel activity	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development response to stimulus response to stress response to wounding response to axon injury transport monoatomic ion transmembrane transport potassium ion transmembrane transport developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development response to stimulus response to stress response to wounding response to axon injury transport monoatomic ion transmembrane transport potassium ion transmembrane transport inorganic ion transmembrane transport establishment of localization metal ion transport inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport potassium ion transport cellular process monoatomic cation transport regulation of cellular process cellular biosynthetic process negative regulation of biological process regulation of DNA biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of DNA metabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process response to decreased oxygen levels cellular response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus regulation of cellular response to hypoxia positive regulation of biological process regulation of cellular response to stress positive regulation of response to stimulus regulation of response to stress positive regulation of cellular response to hypoxia positive regulation of cellular process regulation of response to stimulus behavior multicellular organismal process system process learning or memory nervous system process cognition memory regulation of growth regulation of cardiac muscle tissue growth regulation of developmental process developmental growth cardiac muscle cell proliferation negative regulation of cardiac muscle tissue growth organ growth striated muscle tissue development negative regulation of organ growth multicellular organism development negative regulation of growth regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation regulation of multicellular organismal process cardiac muscle tissue growth muscle tissue development system development striated muscle cell proliferation heart development negative regulation of cell population proliferation heart growth regulation of multicellular organismal development cell population proliferation regulation of developmental growth negative regulation of heart growth cardiac muscle tissue development negative regulation of developmental process growth tissue development circulatory system development negative regulation of developmental growth regulation of cell population proliferation negative regulation of multicellular organismal process negative regulation of cardiac muscle cell proliferation cardiac chamber development cardiac ventricle development response to mechanical stimulus response to external stimulus stabilization of membrane potential regulation of biological quality regulation of membrane potential signaling G protein-coupled receptor signaling pathway signal transduction cell communication	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane glial cell projection cell projection plasma membrane bounded cell projection astrocyte projection cell surface voltage-gated potassium channel complex protein-containing complex cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane glial cell projection cell projection plasma membrane bounded cell projection astrocyte projection cell surface voltage-gated potassium channel complex protein-containing complex plasma membrane protein complex potassium channel complex membrane protein complex cation channel complex transporter complex transmembrane transporter complex monoatomic ion channel complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane axon synapse neuron projection axon terminus presynapse distal axon calyx of Held cell junction neuron projection terminus somatodendritic compartment cell body neuronal cell body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR013099	Potassium channel domain	Domain
A, B	IPR003976	Two pore domain potassium channel, TREK	Family
A, B	IPR003280	Two pore domain potassium channel	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O95069	melancholia endogenous depression adrenal cortex carcinoma depressive disorder General anesthesia osteosarcoma interstitial cystitis pilocytic astrocytoma medulloblastoma neurotic disorder psoriasis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Ion channel (VIC) superfamily	Two pore Na+ channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.