4U2Q

Full-length AMPA subtype ionotropic glutamate receptor GluA2 in complex with partial agonist kainate

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyType 2 solute binding protein-like 8036483 3000083 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyType 2 solute binding protein-like 8036483 3000083 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyType 2 solute binding protein-like 8036483 3000083 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyType 2 solute binding protein-like 8036483 3000083 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALig_chane4u2qA2 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: Lig_chanECOD (1.6)
AANF_receptor_2nde4u2qA5 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)
AANF_receptor_1ste4u2qA3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_1stECOD (1.6)
ALig_chan_3e4u2qA1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: Lig_chan_3ECOD (1.6)
ASBP_bac_3_1ste4u2qA4 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: SBP_bac_3_1stECOD (1.6)
BLig_chane4u2qB2 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: Lig_chanECOD (1.6)
BANF_receptor_2nde4u2qB4 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)
BANF_receptor_1ste4u2qB1 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_1stECOD (1.6)
BLig_chan_3e4u2qB3 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: Lig_chan_3ECOD (1.6)
BSBP_bac_3_1ste4u2qB5 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: SBP_bac_3_1stECOD (1.6)
CLig_chane4u2qC1 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: Lig_chanECOD (1.6)
CANF_receptor_2nde4u2qC2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)
CANF_receptor_1ste4u2qC4 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_1stECOD (1.6)
CLig_chan_3e4u2qC5 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: Lig_chan_3ECOD (1.6)
CSBP_bac_3_1ste4u2qC3 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: SBP_bac_3_1stECOD (1.6)
DLig_chane4u2qD4 A: alpha complex topologyX: Voltage-gated ion channels (From Topology)H: Voltage-gated ion channels (From Topology)T: Voltage-gated ion channelsF: Lig_chanECOD (1.6)
DANF_receptor_2nde4u2qD3 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_2ndECOD (1.6)
DANF_receptor_1ste4u2qD2 A: a/b three-layered sandwichesX: Flavodoxin-likeH: Class I glutamine amidotransferase-likeT: Periplasmic binding protein-like IF: ANF_receptor_1stECOD (1.6)
DLig_chan_3e4u2qD5 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: Lig_chan_3ECOD (1.6)
DSBP_bac_3_1ste4u2qD1 A: a/b three-layered sandwichesX: Periplasmic binding protein-like II (From Topology)H: Periplasmic binding protein-like II (From Topology)T: Periplasmic binding protein-like IIF: SBP_bac_3_1stECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00060Ligand-gated ion channel (Lig_chan)Ligand-gated ion channel- Family
A, B, C, D
PF01094Receptor family ligand binding region (ANF_receptor)Receptor family ligand binding region- Family
A, B, C, D
PF10613Ligated ion channel L-glutamate- and glycine-binding site (Lig_chan-Glu_bd)Ligated ion channel L-glutamate- and glycine-binding siteThis region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF ...This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine [2]. It is found in association with Lig_chan, Pfam:PF00060.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Glutamate receptor 2

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D
IPR028082Periplasmic binding protein-like IHomologous Superfamily
A, B, C, D
IPR001508Ionotropic glutamate receptor, metazoaFamily
A, B, C, D
IPR001828Receptor, ligand binding regionDomain
A, B, C, D
IPR001320Ionotropic glutamate receptor, C-terminalDomain
A, B, C, D
IPR019594Ionotropic glutamate receptor, L-glutamate and glycine-binding domainDomain
A, B, C, D
IPR015683Ionotropic glutamate receptorFamily

Membrane Protein Annotation: OPM OPM Database Homepage

ChainsExternal LinkTypeClassSuperfamilyFamily
A, B, C, D
OPMTransmembraneAlpha-helical polytopicIon channel (VIC) superfamilyGlutamate-gated Ion Channel (GIC) family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
A, B, C, D
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

ChainsExternal LinkComment
A, B, C, D
MemProtMDAnnotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

ChainsResource LinkGroupSubgroupProtein
A, B, C, D
mpstrucTRANSMEMBRANE PROTEINS: ALPHA-HELICALChannels: Other Ion ChannelsGluA2 Glutamate receptor (AMPA-subtype), apo formA