4UOV

The structure of a tetrameric alpha-carbonic anhydrase from Thermovibrio ammonificans reveals a core formed around intermolecular disulfides, which contribute to its thermostability.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4uova_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Thermovibrio ammonificans ) [TaxId: 228745 ],	SCOPe (2.08)
B	d4uovb_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Thermovibrio ammonificans ) [TaxId: 228745 ],	SCOPe (2.08)
C	d4uovc_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Thermovibrio ammonificans ) [TaxId: 228745 ],	SCOPe (2.08)
D	d4uovd_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Thermovibrio ammonificans ) [TaxId: 228745 ],	SCOPe (2.08)
E	d4uove_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Thermovibrio ammonificans ) [TaxId: 228745 ],	SCOPe (2.08)
F	d4uovf_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	(Thermovibrio ammonificans ) [TaxId: 228745 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Carbonic anhydrase	8065123	3001672	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Carbonic anhydrase	8065123	3001672	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Carbonic anhydrase	8065123	3001672	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Carbonic anhydrase	8065123	3001672	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Carbonic anhydrase	8065123	3001672	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Carbonic anhydrase	8065123	3001672	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Carb_anhydrase	e4uovA1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
B	Carb_anhydrase	e4uovB1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
C	Carb_anhydrase	e4uovC1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
D	Carb_anhydrase	e4uovD1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
E	Carb_anhydrase	e4uovE1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
F	Carb_anhydrase	e4uovF1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
B	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
C	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
D	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
E	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
F	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	CARBONATE DEHYDRATASE	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR041891	Carbonic anhydrase, prokaryotic-like	Family
A, B, C, D, E A, B, C, D, E, F	IPR018338	Carbonic anhydrase, alpha-class, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F	IPR001148	Alpha carbonic anhydrase domain	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR023561	Carbonic anhydrase, alpha-class	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.