4UZJ

STRUCTURE OF THE WNT DEACYLASE NOTUM FROM DROSOPHILA - CRYSTAL FORM I - 2.4A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4uzja1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
A	d4uzja2	Artifacts	Tags	Tags	Tags	N-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d4uzjb1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	automated matches	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d4uzjb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAE	e4uzjA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PAE	ECOD (1.6)
B	PAE	e4uzjB1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PAE	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03283	Pectinacetylesterase (PAE)	Pectinacetylesterase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	NOTUM	hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity catalytic activity palmitoleyl hydrolase activity	developmental process imaginal disc development animal organ development anatomical structure development wing disc development multicellular organismal process digestive system development tube development digestive tract development multicellular organism development anatomical structure morphogenesis tube morphogenesis digestive tract morphogenesis system development developmental process imaginal disc development animal organ development anatomical structure development wing disc development multicellular organismal process digestive system development tube development digestive tract development multicellular organism development anatomical structure morphogenesis tube morphogenesis digestive tract morphogenesis system development pattern specification process regionalization imaginal disc pattern formation wing disc pattern formation cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication cellular process pigmentation regulation of eye pigmentation eye pigmentation regulation of compound eye pigmentation developmental pigmentation regulation of developmental pigmentation compound eye pigmentation regulation of pigmentation central nervous system development ventral cord development nervous system development positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of response to stimulus positive regulation of smoothened signaling pathway positive regulation of cellular process regulation of smoothened signaling pathway smoothened signaling pathway positive regulation of signaling dorsal/ventral pattern formation, imaginal disc wing disc dorsal/ventral pattern formation dorsal/ventral pattern formation catabolic process lipoprotein metabolic process primary metabolic process protein catabolic process macromolecule deacylation protein depalmitoleylation macromolecule catabolic process protein deacylation macromolecule modification metabolic process protein metabolic process macromolecule metabolic process protein modification process lipoprotein catabolic process	cell surface cellular anatomical structure extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004963	Pectinacetylesterase/NOTUM	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.