4UZQ

STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH O-PALMITOLEOYL SERINE - CRYSTAL FORM IX - 1.5A

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PAE	e4uzqA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: PAE	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN NOTUM HOMOLOG	phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity hydrolase activity catalytic activity phospholipase activity lipase activity carboxylic ester hydrolase activity palmitoleyl hydrolase activity	developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development animal organ development bone development system development cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development animal organ development bone development system development cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication cellular process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process lipoprotein metabolic process primary metabolic process protein catabolic process macromolecule deacylation protein depalmitoleylation macromolecule catabolic process protein deacylation macromolecule modification metabolic process protein metabolic process macromolecule metabolic process protein modification process lipoprotein catabolic process regulation of multicellular organismal development regulation of developmental process bone mineralization regulation of biomineral tissue development regulation of bone mineralization tissue development ossification biomineral tissue development regulation of multicellular organismal process regulation of ossification	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm extracellular region
B	PROTEIN WNT-7A	protein binding binding signaling receptor binding G protein-coupled receptor binding frizzled binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity cytokine activity	regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process regulation of cellular component size cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis regulation of axon diameter cellular component organization regulation of neuron projection development multicellular organismal process axonogenesis regulation of cellular component organization regulation of cellular process cellular developmental process regulation of developmental process regulation of cellular component size cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis regulation of axon diameter cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis regulation of axonogenesis cell differentiation anatomical structure development cellular component organization or biogenesis regulation of biological quality regulation of anatomical structure morphogenesis system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development regulation of cell projection size axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development cellular process regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size epithelium development sensory organ development eye development animal organ development visual system development tissue development lens fiber cell development epithelial cell differentiation epithelial cell development camera-type eye development lens fiber cell differentiation sensory system development lens development in camera-type eye oviduct development reproductive system development tube development reproductive process developmental process involved in reproduction reproductive structure development cellular response to stimulus positive regulation of cell communication regulation of postsynaptic membrane potential system process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction positive regulation of cellular process trans-synaptic signaling regulation of signaling cell surface receptor signaling pathway nervous system process cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling wound healing cell population proliferation positive regulation of cell population proliferation positive regulation of epithelial cell proliferation response to stress regulation of cell population proliferation regulation of epithelial cell proliferation response to wounding epithelial cell proliferation positive regulation of epithelial cell proliferation involved in wound healing limb development appendage development embryonic forelimb morphogenesis embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development forelimb morphogenesis appendage morphogenesis limb morphogenesis canonical Wnt signaling pathway Wnt signaling pathway cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process dorsal/ventral pattern formation pattern specification process regionalization apoptotic process cell death programmed cell death uterus development uterus morphogenesis animal organ morphogenesis postsynapse organization postsynapse assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly synapse organization synapse assembly positive regulation of nervous system development positive regulation of cellular component organization regulation of nervous system development positive regulation of developmental process regulation of excitatory synapse assembly regulation of synapse structure or activity regulation of synapse assembly regulation of multicellular organismal development positive regulation of cellular component biogenesis positive regulation of excitatory synapse assembly regulation of cellular component biogenesis excitatory synapse assembly regulation of cell junction assembly regulation of synapse organization positive regulation of cell junction assembly positive regulation of multicellular organismal process positive regulation of synapse assembly establishment of cell polarity establishment or maintenance of cell polarity embryonic hindlimb morphogenesis hindlimb morphogenesis cell aggregation connective tissue development cartilage condensation skeletal system development skeletal system morphogenesis cartilage development intracellular signal transduction positive regulation of JNK cascade regulation of intracellular signal transduction JNK cascade intracellular signaling cassette positive regulation of MAPK cascade regulation of JNK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade Wnt signaling pathway, planar cell polarity pathway non-canonical Wnt signaling pathway blood vessel morphogenesis central nervous system vasculogenesis vasculogenesis vasculature development circulatory system development tube morphogenesis blood vessel development secondary palate development roof of mouth development morphogenesis of an epithelium epiboly involved in wound healing morphogenesis of an epithelial sheet wound healing, spreading of epidermal cells tissue morphogenesis epiboly cell migration wound healing, spreading of cells cell motility cell proliferation in forebrain head development forebrain development brain development central nervous system development neural precursor cell proliferation cell fate commitment dendrite development dendritic spine morphogenesis dendritic spine development dendritic spine organization dendrite morphogenesis neuron projection organization somatic stem cell population maintenance maintenance of cell number stem cell population maintenance skeletal muscle satellite cell activation cell activation negative regulation of biological process regulation of cell differentiation regulation of neurogenesis regulation of cell development negative regulation of neurogenesis negative regulation of cellular process negative regulation of nervous system development negative regulation of cell differentiation negative regulation of developmental process negative regulation of cell development negative regulation of multicellular organismal process chondrocyte differentiation positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of postsynapse organization regulation of localization cellular localization regulated exocytosis transport synaptic vesicle cycle synaptic vesicle exocytosis vesicle-mediated transport vesicle-mediated transport in synapse regulation of regulated secretory pathway localization regulation of secretion by cell secretion by cell signal release establishment of localization in cell neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport regulation of synaptic vesicle exocytosis export from cell neurotransmitter transport regulation of vesicle-mediated transport establishment of localization regulation of secretion signal release from synapse exocytosis regulation of neurotransmitter secretion regulation of exocytosis presynapse organization presynapse assembly tissue regeneration skeletal muscle tissue regeneration developmental growth skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration growth regeneration protein localization regulation of protein localization to presynapse protein localization to synapse regulation of protein localization positive regulation of protein localization to synapse positive regulation of protein localization to presynapse regulation of protein localization to synapse protein localization to presynapse regulation of cellular localization cellular macromolecule localization macromolecule localization positive regulation of protein localization protein localization to cell junction organonitrogen compound metabolic process positive regulation of protein metabolic process regulation of protein metabolic process protein metabolic process establishment of blood-brain barrier positive regulation of locomotion regulation of cell motility endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration regulation of endothelial cell migration epithelial cell migration regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion positive regulation of endothelial cell migration response to hormone response to endogenous stimulus response to chemical response to estrogen angiogenesis anatomical structure formation involved in morphogenesis cellular response to endogenous stimulus cellular response to growth factor stimulus response to transforming growth factor beta cellular response to transforming growth factor beta stimulus response to growth factor synaptic vesicle recycling negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of presynapse assembly regulation of presynapse organization cell fate determination asymmetric protein localization involved in cell fate determination sex differentiation embryonic axis specification embryonic pattern specification axis specification stem cell development stem cell differentiation somatic stem cell division stem cell division cell division cerebellar cortex morphogenesis hindbrain morphogenesis central nervous system neuron differentiation cerebellar granular layer morphogenesis metencephalon development cerebellar cortex formation cerebellum morphogenesis cerebellar granular layer development glutamatergic neuron differentiation cerebellar cortex development cerebellum development cerebellar granule cell differentiation hindbrain development cerebellar granular layer formation cell differentiation in hindbrain response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound embryonic digit morphogenesis	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle synapse cell junction glutamatergic synapse intracellular anatomical structure extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle synapse cell junction glutamatergic synapse intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane cytoplasm organelle membrane endocytic vesicle membrane-enclosed lumen endomembrane system intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum cell surface cell periphery plasma membrane presynapse extracellular matrix external encapsulating structure Golgi apparatus Golgi lumen Schaffer collateral - CA1 synapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR004963	Pectinacetylesterase/NOTUM	Family
B	IPR013300	Wnt-7 protein	Family
B	IPR043158	Wnt, C-terminal domain	Homologous Superfamily
B	IPR005817	Wnt	Family
B	IPR018161	Wnt protein, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q6P988	attention deficit hyperactivity disorder, inattentive type psoriasis
B	Pharos: O00755	Fuhrmann syndrome phocomelia, Schinzel type Female Urogenital Diseases ovarian cancer amyotrophic lateral sclerosis type 1 urogenital neoplasm polydactyly intellectual disability ovarian neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.