Navigation Tabs
Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one External Resource: Annotation Chains Type Family Name Domain Identifier Family Identifier Provenance Source (Version) A SCOP2B Superfamily NAD(P)-linked oxidoreductase 8039875 3000288 SCOP2B (2022-06-29) B SCOP2B Superfamily NAD(P)-linked oxidoreductase 8039875 3000288 SCOP2B (2022-06-29)
Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A Aldo_ket_red e4xo6A1 A: a/b barrels X: TIM beta/alpha-barrel H: TIM barrels (From Topology) T: TIM barrels F: Aldo_ket_red ECOD (1.6) B Aldo_ket_red e4xo6B1 A: a/b barrels X: TIM beta/alpha-barrel H: TIM barrels (From Topology) T: TIM barrels F: Aldo_ket_red ECOD (1.6)
Chains Accession Name Description Comments Source PF00248 Aldo/keto reductase family (Aldo_ket_red) Aldo/keto reductase family This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2]. Domain
Chains Polymer Molecular Function Biological Process Cellular Component Aldo-keto reductase family 1 member C2 oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity oxidoreductase activity, acting on the CH-CH group of donors catalytic activity bile acid binding organic acid binding binding ion binding anion binding carboxylic acid binding monocarboxylic acid binding small molecule binding indanol dehydrogenase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors aldo-keto reductase (NADPH) activity alcohol dehydrogenase [NAD(P)+] activity alcohol dehydrogenase (NADP+) activity aldose reductase (NADPH) activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ketosteroid monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor steroid dehydrogenase activity steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor androstan-3-alpha,17-beta-diol dehydrogenase activity androsterone dehydrogenase activity estradiol 17-beta-dehydrogenase [NAD(P)+] activity
Chains Drug Target Associated Disease Pharos P52895
