4YPM
Crystal structure of a LonA protease domain in complex with bortezomib
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Lon | e4ypmA3 | A: alpha arrays | X: Histone-like | H: Histone-related | T: AAA+ ATPase lid domain | F: Lon | ECOD (1.6) |
A | Lon_C_N | e4ypmA1 | A: a+b two layers | X: Ribosomal protein S5 domain 2-like (From Topology) | H: Ribosomal protein S5 domain 2-like (From Topology) | T: Ribosomal protein S5 domain 2-like | F: Lon_C_N | ECOD (1.6) |
A | Lon_C_C | e4ypmA2 | A: a/b three-layered sandwiches | X: C-terminal subdomain in Lon-related proteases catalytic domains (From Topology) | H: C-terminal subdomain in Lon-related proteases catalytic domains (From Topology) | T: C-terminal subdomain in Lon-related proteases catalytic domains | F: Lon_C_C | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF05362 | Lon protease (S16) C-terminal proteolytic domain (Lon_C) | Lon protease (S16) C-terminal proteolytic domain | The Lon serine proteases must hydrolyse ATP to degrade protein substrates. In Escherichia coli, these proteases are involved in turnover of intracellular proteins, including abnormal proteins following heat-shock. The active site for protease activit ... | Domain | |
PF22667 | Lon protease AAA+ ATPase lid domain (Lon_lid) | Lon protease AAA+ ATPase lid domain | This entry represents the AAA+ ATPase lid domain of Lon proteases [1-5]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR027543 | Lon protease, bacterial | Family | |
IPR015947 | PUA-like superfamily | Homologous Superfamily | |
IPR046336 | Lon protease, N-terminal domain superfamily | Homologous Superfamily | |
IPR003111 | Lon protease, N-terminal domain | Domain | |
IPR004815 | Lon protease, bacterial/eukaryotic-type | Family | |
IPR003593 | AAA+ ATPase domain | Domain | |
IPR008269 | Peptidase S16, Lon proteolytic domain | Domain | |
IPR027065 | Lon protease | Family | |
IPR008268 | Peptidase S16, active site | Active Site | |
IPR003959 | ATPase, AAA-type, core | Domain | |
IPR020568 | Ribosomal protein uS5 domain 2-type superfamily | Homologous Superfamily | |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily | |
IPR014721 | Small ribosomal subunit protein uS5 domain 2-type fold, subgroup | Homologous Superfamily |