Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyDisA linker domain-like 8089949 3002406 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyDacA-like 8089951 3001724 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyHelix-hairpin-helix tandem 8089953 3000163 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDisA linker domain-like 8089949 3002406 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyHelix-hairpin-helix tandem 8089953 3000163 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDacA-like 8089951 3001724 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHHH_9e4yvzA3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHH_9ECOD (1.6)
ADisA-linkere4yvzA2 A: alpha bundlesX: DisA helical linker domain (From Topology)H: DisA helical linker domain (From Topology)T: DisA helical linker domainF: DisA-linkerECOD (1.6)
ADisA_Ne4yvzA1 A: a+b three layersX: DisA nucleotide-binding domain (From Topology)H: DisA nucleotide-binding domain (From Topology)T: DisA nucleotide-binding domainF: DisA_NECOD (1.6)
BHHHe4yvzB3 A: alpha arraysX: HhH/H2THH: SAM/DNA-glycosylaseT: SAM domain-likeF: HHHECOD (1.6)
BDisA-linkere4yvzB2 A: alpha bundlesX: DisA helical linker domain (From Topology)H: DisA helical linker domain (From Topology)T: DisA helical linker domainF: DisA-linkerECOD (1.6)
BDisA_Ne4yvzB1 A: a+b three layersX: DisA nucleotide-binding domain (From Topology)H: DisA nucleotide-binding domain (From Topology)T: DisA nucleotide-binding domainF: DisA_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00633Helix-hairpin-helix motif (HHH)Helix-hairpin-helix motif- Motif
A, B
PF10635DisA bacterial checkpoint controller linker region (DisA-linker)DisA bacterial checkpoint controller linker regionThe DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. the first, N-terminal region, from 1-145 is globular and is represented by family DisA_N, Pfam:PF02457; the n ...The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. the first, N-terminal region, from 1-145 is globular and is represented by family DisA_N, Pfam:PF02457; the next 146-289 residues is this domain that consists of an elongated bundle of three alpha helices (alpha-6, alpha-10, and alpha-11), one side of which carries an additional three helices (alpha7-9), thus forming a spine like-linker between domains 1 and 3. The C-terminal residues of domain 3 are family HHH, Pfam:PF00633, the specific DNA-binding domain. The octameric complex thus has structurally linked nucleotide-binding and DNA-binding HhH domains and the nucleotide-binding domains are bound to a cyclic di-adenosine phosphate such that DisA is a specific di-adenylate cyclase. The di-adenylate cyclase activity is strongly suppressed by binding to branched DNA, but not to duplex or single-stranded DNA, suggesting a role for DisA as a monitor of the presence of stalled replication forks or recombination intermediates via DNA structure-modulated c-di-AMP synthesis [1].
Domain
A, B
PF02457DisA bacterial checkpoint controller nucleotide-binding (DAC)DisA bacterial checkpoint controller nucleotide-binding- Family