4YXM
Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Helix-hairpin-helix tandem | 8089953 | 3000163 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | DisA linker domain-like | 8089949 | 3002406 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | DacA-like | 8089951 | 3001724 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | DisA linker domain-like | 8089949 | 3002406 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Helix-hairpin-helix tandem | 8089953 | 3000163 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | DacA-like | 8089951 | 3001724 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | HHH | e4yxmA3 | A: alpha arrays | X: HhH/H2TH | H: SAM/DNA-glycosylase | T: SAM domain-like | F: HHH | ECOD (1.6) |
A | DisA-linker | e4yxmA2 | A: alpha bundles | X: DisA helical linker domain (From Topology) | H: DisA helical linker domain (From Topology) | T: DisA helical linker domain | F: DisA-linker | ECOD (1.6) |
A | DisA_N | e4yxmA1 | A: a+b three layers | X: DisA nucleotide-binding domain (From Topology) | H: DisA nucleotide-binding domain (From Topology) | T: DisA nucleotide-binding domain | F: DisA_N | ECOD (1.6) |
B | HHH_9 | e4yxmB3 | A: alpha arrays | X: HhH/H2TH | H: SAM/DNA-glycosylase | T: SAM domain-like | F: HHH_9 | ECOD (1.6) |
B | DisA-linker | e4yxmB2 | A: alpha bundles | X: DisA helical linker domain (From Topology) | H: DisA helical linker domain (From Topology) | T: DisA helical linker domain | F: DisA-linker | ECOD (1.6) |
B | DisA_N | e4yxmB1 | A: a+b three layers | X: DisA nucleotide-binding domain (From Topology) | H: DisA nucleotide-binding domain (From Topology) | T: DisA nucleotide-binding domain | F: DisA_N | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.1700.10 | Alpha Beta | 3-Layer(aba) Sandwich | YojJ-like (1 | DNA integrity scanning protein, DisA, N-terminal domain | CATH (4.3.0) |
A | 1.20.1260.110 | Mainly Alpha | Up-down Bundle | Ferritin | DNA integrity scanning linker region | CATH (4.3.0) |
A | 1.10.150.20 | Mainly Alpha | Orthogonal Bundle | DNA polymerase | domain 1 | CATH (4.3.0) |
B | 3.40.1700.10 | Alpha Beta | 3-Layer(aba) Sandwich | YojJ-like (1 | DNA integrity scanning protein, DisA, N-terminal domain | CATH (4.3.0) |
B | 1.20.1260.110 | Mainly Alpha | Up-down Bundle | Ferritin | DNA integrity scanning linker region | CATH (4.3.0) |
B | 1.10.150.20 | Mainly Alpha | Orthogonal Bundle | DNA polymerase | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00633 | Helix-hairpin-helix motif (HHH) | Helix-hairpin-helix motif | - | Motif | |
PF10635 | DisA bacterial checkpoint controller linker region (DisA-linker) | DisA bacterial checkpoint controller linker region | The DisA protein is a bacterial checkpoint protein that dimerises into an octameric complex. The protein consists of three distinct domains. the first, N-terminal region, from 1-145 is globular and is represented by family DisA_N, Pfam:PF02457; the n ... | Domain | |
PF02457 | DisA bacterial checkpoint controller nucleotide-binding (DAC) | DisA bacterial checkpoint controller nucleotide-binding | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR023763 | DNA integrity scanning protein, DisA | Family | |
IPR000445 | Helix-hairpin-helix motif | Conserved Site | |
IPR018906 | DNA integrity scanning, DisA, linker region | Domain | |
IPR038331 | DisA, linker domain superfamily | Homologous Superfamily | |
IPR010994 | RuvA domain 2-like | Homologous Superfamily | |
IPR050338 | DNA integrity scanning protein DisA | Family | |
IPR036888 | DNA integrity scanning protein, DisA, N-terminal domain superfamily | Homologous Superfamily | |
IPR003390 | DNA integrity scanning protein, DisA, N-terminal | Domain |