4ZXH
Crystal Structure of holo-AB3403 a four domain nonribosomal peptide synthetase from Acinetobacter Baumanii
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | AMP-binding_3rd | e4zxhA4 | A: beta barrels | X: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | H: beta-barrel domain in acetyl-CoA synthetase-like proteins (From Topology) | T: beta-barrel domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_3rd | ECOD (1.6) |
A | PP-binding | e4zxhA6 | A: alpha bundles | X: ACP-like | H: Acyl-carrier protein (ACP) (From Topology) | T: Acyl-carrier protein (ACP) | F: PP-binding | ECOD (1.6) |
A | AMP-binding_C | e4zxhA3 | A: a+b two layers | X: Alpha-lytic protease prodomain-like | H: a+b domain in acetyl-CoA synthetase-like proteins (From Topology) | T: a+b domain in acetyl-CoA synthetase-like proteins | F: AMP-binding_C | ECOD (1.6) |
A | Condensation_N | e4zxhA7 | A: a+b complex topology | X: CoA-dependent acyltransferases (From Topology) | H: CoA-dependent acyltransferases (From Topology) | T: CoA-dependent acyltransferases | F: Condensation_N | ECOD (1.6) |
A | Condensation_C_2 | e4zxhA1 | A: a+b complex topology | X: CoA-dependent acyltransferases (From Topology) | H: CoA-dependent acyltransferases (From Topology) | T: CoA-dependent acyltransferases | F: Condensation_C_2 | ECOD (1.6) |
A | Hydrolase_4_1 | e4zxhA8 | A: a/b three-layered sandwiches | X: alpha/beta-Hydrolases (From Topology) | H: alpha/beta-Hydrolases (From Topology) | T: alpha/beta-Hydrolases | F: Hydrolase_4_1 | ECOD (1.6) |
A | AMP-binding_1st | e4zxhA5 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_1st | ECOD (1.6) |
A | AMP-binding_2nd | e4zxhA9 | A: a/b three-layered sandwiches | X: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | H: Rossmann-like domain in Acetyl-CoA synthetase-like proteins (From Topology) | T: Rossmann-like domain in Acetyl-CoA synthetase-like proteins | F: AMP-binding_2nd | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00501 | AMP-binding enzyme (AMP-binding) | AMP-binding enzyme | - | Family | |
PF00975 | Thioesterase domain (Thioesterase) | Thioesterase domain | Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of v ... | Domain | |
PF00668 | Condensation domain (Condensation) | Condensation domain | - | Family | |
PF13193 | AMP-binding enzyme C-terminal domain (AMP-binding_C) | AMP-binding enzyme C-terminal domain | This is a small domain that is found C terminal to Pfam:PF00501. It has a central beta sheet core that is flanked by alpha helices. | Domain | |
PF00550 | Phosphopantetheine attachment site (PP-binding) | Phosphopantetheine attachment site | A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
---|---|---|---|---|
ABBFA_003403 | - |
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR006162 | Phosphopantetheine attachment site | PTM | |
IPR009081 | Phosphopantetheine binding ACP domain | Domain | |
IPR010071 | Amino acid adenylation domain | Domain | |
IPR029058 | Alpha/Beta hydrolase fold | Homologous Superfamily | |
IPR020845 | AMP-binding, conserved site | Conserved Site | |
IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily | Homologous Superfamily | |
IPR020802 | Polyketide synthase, thioesterase domain | Domain | |
IPR045851 | AMP-binding enzyme, C-terminal domain superfamily | Homologous Superfamily | |
IPR020806 | Polyketide synthase, phosphopantetheine-binding domain | Domain | |
IPR001242 | Condensation domain | Domain | |
IPR036736 | ACP-like superfamily | Homologous Superfamily | |
IPR025110 | AMP-binding enzyme, C-terminal domain | Domain | |
IPR000873 | AMP-dependent synthetase/ligase domain | Domain | |
IPR001031 | Thioesterase | Domain |