4ZYO

Crystal Structure of Human Integral Membrane Stearoyl-CoA Desaturase with Substrate

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	FA_desaturase	e4zyoA1	A: alpha complex topology	X: Integral membrane Acyl-CoA desaturase (From Topology)	H: Integral membrane Acyl-CoA desaturase (From Topology)	T: Integral membrane Acyl-CoA desaturase	F: FA_desaturase	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Acyl-CoA desaturase	oxidoreductase activity catalytic activity acyl-CoA desaturase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water stearoyl-CoA 9-desaturase activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding palmitoyl-CoA 9-desaturase activity	multicellular organismal process regulation of biological process regulation of cellular process homeostatic process biological regulation positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process multicellular organismal process regulation of biological process regulation of cellular process homeostatic process biological regulation positive regulation of biological process adaptive thermogenesis positive regulation of metabolic process multicellular organismal-level homeostasis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of multicellular organismal process cellular process metabolic process regulation of multicellular organismal process regulation of metabolic process positive regulation of cellular process fatty acid metabolic process unsaturated fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process oxoacid metabolic process carboxylic acid metabolic process lipid biosynthetic process primary metabolic process organic acid biosynthetic process organic acid metabolic process fatty acid biosynthetic process carboxylic acid biosynthetic process unsaturated fatty acid biosynthetic process biosynthetic process small molecule metabolic process monocarboxylic acid metabolic process lipid metabolic process response to lipid response to stimulus response to fatty acid response to chemical response to oxygen-containing compound monounsaturated fatty acid biosynthetic process monounsaturated fatty acid metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane endoplasmic reticulum cytoplasm endomembrane system organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR015876	Acyl-CoA desaturase	Family
A	IPR001522	Fatty acid desaturase type 1, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00767	sarcomatoid carcinoma liver cancer carcinoma Mammary Neoplasms, Experimental non-alcoholic fatty liver disease pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hydrolethalus syndrome polycystic ovary syndrome invasive ductal breast carcinoma type 2 diabetes mellitus adenoma liver neoplasm malignant colon neoplasm breast cancer sarcomatoid carcinoma liver cancer carcinoma Mammary Neoplasms, Experimental non-alcoholic fatty liver disease pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia hydrolethalus syndrome polycystic ovary syndrome invasive ductal breast carcinoma type 2 diabetes mellitus adenoma liver neoplasm malignant colon neoplasm breast cancer malignant mesothelioma chronic obstructive pulmonary disease mammary neoplasms, animal Crohn disease Down syndrome non-small cell lung carcinoma osteosarcoma Emery-Dreifuss muscular dystrophy pancreatic intraductal papillary-mucinous carcinoma heart disease Pick disease inborn carbohydrate metabolic disorder progressive supranuclear palsy large cell medulloblastoma Sjogren syndrome ulcerative colitis Alzheimer disease lung carcinoma astrocytic tumor malignant ependymoma malignant pancreatic neoplasm congestive heart failure cystic fibrosis myopathy obesity disorder Duchenne muscular dystrophy ovarian cancer glioblastoma pancreatic intraductal papillary-mucinous neoplasm hepatocellular carcinoma pituitary cancer interstitial cystitis psoriasis limb-girdle muscular dystrophy undifferentiated carcinoma lysosomal lipid storage disorder atypical teratoid rhabdoid tumor malignant glioma medulloblastoma oligodendroglioma ductal breast carcinoma in situ

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Fatty acid desaturase/hydroxylase	Fatty acid desaturase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Fatty Acid Desaturases	Stearoyl-coenzyme A desaturase (SCD1) in complex with substrate

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.