Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyDomain of poly(ADP-ribose) polymerase 8036812 3000280 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyADP-ribosylation 8036814 3001208 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APARP_rege5a00A1 A: alpha bundlesX: Domain of poly(ADP-ribose) polymerase (From Topology)H: Domain of poly(ADP-ribose) polymerase (From Topology)T: Domain of poly(ADP-ribose) polymeraseF: PARP_regECOD (1.6)
APARPe5a00A2 A: a+b complex topologyX: ADP-ribosylation (From Topology)H: ADP-ribosylation (From Topology)T: ADP-ribosylationF: PARPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.20.142.10 Mainly Alpha Up-down Bundle Poly(ADP-ribose) Polymerase domain 1CATH (4.3.0)
A3.90.228.10 Alpha Beta Alpha-Beta Complex Phosphoenolpyruvate Carboxykinase domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00644Poly(ADP-ribose) polymerase catalytic domain (PARP)Poly(ADP-ribose) polymerase catalytic domain- Family
PF02877Poly(ADP-ribose) polymerase, regulatory domain (PARP_reg)Poly(ADP-ribose) polymerase, regulatory domainPoly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active [2].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
POLY [ADP-RIBOSE] POLYMERASE 1