5A64

Crystal structure of mouse thiamine triphosphatase in complex with thiamine triphosphate.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5a64b_	Alpha and beta proteins (a+b)	CYTH-like phosphatases	CYTH-like phosphatases	CYTH domain	Thiamine-triphosphatase (ThTPase)	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
A	d5a64a_	Alpha and beta proteins (a+b)	CYTH-like phosphatases	CYTH-like phosphatases	CYTH domain	Thiamine-triphosphatase (ThTPase)	HOUSE MOUSE (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	CYTH-like phosphatases	8034698	3001426	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	CYTH-like phosphatases	8034698	3001426	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	CYTH	e5a64B1	A: a+b complex topology	X: mRNA triphosphatase CET1-related (From Topology)	H: mRNA triphosphatase CET1-related (From Topology)	T: mRNA triphosphatase CET1-related	F: CYTH	ECOD (1.6)
A	CYTH	e5a64A1	A: a+b complex topology	X: mRNA triphosphatase CET1-related (From Topology)	H: mRNA triphosphatase CET1-related (From Topology)	T: mRNA triphosphatase CET1-related	F: CYTH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	2.40.320.10	Mainly Beta	Beta Barrel	Hypothetical Protein Pfu-838710-001	Hypothetical Protein Pfu-838710-001	CATH (4.3.0)
A	2.40.320.10	Mainly Beta	Beta Barrel	Hypothetical Protein Pfu-838710-001	Hypothetical Protein Pfu-838710-001	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01928	CYTH domain (CYTH)	CYTH domain	These sequences are functionally identified as members of the adenylate cyclase family, which catalyses the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. Six distinct non-homologous classes of AC have been identified. The structure of th ...	These sequences are functionally identified as members of the adenylate cyclase family, which catalyses the conversion of ATP to 3',5'-cyclic AMP and pyrophosphate. Six distinct non-homologous classes of AC have been identified. The structure of three classes of adenylyl cyclases have been solved [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	THIAMINE TRIPHOSPHATASE	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity thiamine triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity	pyrimidine-containing compound metabolic process cellular metabolic process organic hydroxy compound metabolic process thiamine-containing compound metabolic process alcohol metabolic process thiamine metabolic process vitamin metabolic process small molecule metabolic process metabolic process sulfur compound metabolic process cellular process water-soluble vitamin metabolic process primary alcohol metabolic process cellular biosynthetic process pyrimidine-containing compound metabolic process cellular metabolic process organic hydroxy compound metabolic process thiamine-containing compound metabolic process alcohol metabolic process thiamine metabolic process vitamin metabolic process small molecule metabolic process metabolic process sulfur compound metabolic process cellular process water-soluble vitamin metabolic process primary alcohol metabolic process cellular biosynthetic process vitamin biosynthetic process phosphate-containing compound metabolic process thiamine diphosphate metabolic process pyrimidine-containing compound biosynthetic process phosphorus metabolic process water-soluble vitamin biosynthetic process small molecule biosynthetic process sulfur compound biosynthetic process biosynthetic process organophosphate metabolic process organophosphate biosynthetic process thiamine diphosphate biosynthetic process thiamine-containing compound biosynthetic process dephosphorylation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023577	CYTH domain	Domain
A, B	IPR039582	Thiamine-triphosphatase	Family
A, B	IPR033469	CYTH-like domain superfamily	Homologous Superfamily
A, B	IPR012177	Thiamine triphosphatase, eukaryotes	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.