5AAN

Crystal structure of Drosophila NCS-1 bound to penothiazine FD44

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5aana_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	automated matches	FRUIT FLY (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8078475	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_7_2	e5aanA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_2	ECOD (1.6)
A	EF-hand_7_10	e5aanA2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_7_10	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain
A	PF00036	EF hand (EF-hand_1)	EF hand	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typica ...	The EF-hands can be divided into two classes: signalling proteins and buffering/transport proteins. The first group is the largest and includes the most well-known members of the family such as calmodulin, troponin C and S100B. These proteins typically undergo a calcium-dependent conformational change which opens a target binding site. The latter group is represented by calbindin D9k and do not undergo calcium dependent conformational changes.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	CG5907-PA, ISOFORM A	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity cyclase regulator activity enzyme activator activity cyclase activator activity molecular function activator activity calcium sensitive guanylate cyclase activator activity guanylate cyclase activator activity molecular function regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity cyclase regulator activity enzyme activator activity cyclase activator activity molecular function activator activity calcium sensitive guanylate cyclase activator activity guanylate cyclase activator activity molecular function regulator activity guanylate cyclase regulator activity	trans-synaptic signaling synaptic signaling regulation of biological process signaling anterograde trans-synaptic signaling biological regulation cell-cell signaling cellular process chemical synaptic transmission cell communication cellular localization neurotransmitter secretion transport secretion trans-synaptic signaling synaptic signaling regulation of biological process signaling anterograde trans-synaptic signaling biological regulation cell-cell signaling cellular process chemical synaptic transmission cell communication cellular localization neurotransmitter secretion transport secretion export from cell neurotransmitter transport establishment of localization localization signal release from synapse secretion by cell signal release establishment of localization in cell vesicle-mediated transport cellular component organization cell junction organization neuromuscular junction development synapse organization cellular component organization or biogenesis regulation of localization regulation of cellular process modulation of chemical synaptic transmission regulation of secretion by cell regulation of signaling regulation of transport regulation of neurotransmitter transport regulation of secretion regulation of trans-synaptic signaling regulation of neurotransmitter secretion regulation of cell communication	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle transport vesicle synapse intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle presynapse cytoplasmic vesicle synaptic vesicle organelle intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle transport vesicle synapse intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle presynapse cytoplasmic vesicle synaptic vesicle organelle cell junction secretory vesicle vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028846	Recoverin family	Family
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.