5AAV

Optimization of a novel binding motif to to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H- pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyNuclear receptor ligand-binding domain 8044103 3001442 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyNuclear receptor ligand-binding domain 8044103 3001442 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AHormone_recepe5aavA1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recepECOD (1.6)
BHormone_recep_1e5aavB1 A: alpha arraysX: Nuclear receptor ligand-binding domain (From Topology)H: Nuclear receptor ligand-binding domain (From Topology)T: Nuclear receptor ligand-binding domainF: Hormone_recep_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)
B1.10.565.10 Mainly Alpha Orthogonal Bundle Retinoid X Receptor Retinoid X ReceptorCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00104Ligand-binding domain of nuclear hormone receptor (Hormone_recep)Ligand-binding domain of nuclear hormone receptorThis all helical domain is involved in binding the hormone in these receptors.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ESTROGEN RECEPTOR
ESTROGEN RECEPTOR

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
PharosP03372
PharosP03372