5AF2

Crystal structure of the C-terminal 2',5'-phosphodiesterase domain of group A rotavirus protein VP3

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	LigT-like	8104144	3001408	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	LigT-like	8104144	3001408	SCOP2B (2022-06-29)
C	SCOP2 Family	NS2A PDE domain-like	8046962	4005388	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	LigT-like	8104144	3001408	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	LigT-like	8104144	3001408	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Corona_NS2A	e5af2A1	A: beta barrels	X: LigT-like	H: LigT-related (From Topology)	T: LigT-related	F: Corona_NS2A	ECOD (1.6)
B	Corona_NS2A	e5af2B1	A: beta barrels	X: LigT-like	H: LigT-related (From Topology)	T: LigT-related	F: Corona_NS2A	ECOD (1.6)
C	Corona_NS2A	e5af2C1	A: beta barrels	X: LigT-like	H: LigT-related (From Topology)	T: LigT-related	F: Corona_NS2A	ECOD (1.6)
D	Corona_NS2A	e5af2D1	A: beta barrels	X: LigT-like	H: LigT-related (From Topology)	T: LigT-related	F: Corona_NS2A	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF05213	Coronavirus NS2A protein (Corona_NS2A)	Coronavirus NS2A protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	VP3	guanylyltransferase activity mRNA guanylyltransferase activity RNA guanylyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid transferase activity catalytic activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity hydrolase activity RNA binding guanylyltransferase activity mRNA guanylyltransferase activity RNA guanylyltransferase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid transferase activity catalytic activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity hydrolase activity RNA binding binding organic cyclic compound binding nucleic acid binding RNA methyltransferase activity transferase activity, transferring one-carbon groups S-adenosylmethionine-dependent methyltransferase activity mRNA 5'-cap (guanine-N7-)-methyltransferase activity N-methyltransferase activity methyltransferase activity mRNA methyltransferase activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	symbiont-mediated perturbation of host defense response biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process viral process modulation by virus of host process virus-mediated perturbation of host defense response modulation of process of another organism biological process involved in interaction with host modulation by virus of host cellular process biological process involved in symbiotic interaction response to host defenses response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host defense response biological process involved in interspecies interaction between organisms symbiont-mediated perturbation of host process viral process modulation by virus of host process virus-mediated perturbation of host defense response modulation of process of another organism biological process involved in interaction with host modulation by virus of host cellular process biological process involved in symbiotic interaction response to host defenses response to stimulus response to other organism symbiont-mediated perturbation of host immune response symbiont-mediated perturbation of host defenses response to defenses of other organism response to external stimulus response to biotic stimulus symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated suppression of host defenses symbiont-mediated perturbation of host innate immune response response to host response to external biotic stimulus RNA (guanine-N7)-methylation RNA metabolic process 7-methylguanosine RNA capping RNA capping nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA processing RNA 5'-cap (guanine-N7)-methylation primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process macromolecule methylation RNA modification biosynthetic process methylation macromolecule modification RNA 5'-end processing metabolic process cellular process macromolecule metabolic process RNA methylation	viral nucleocapsid viral capsid virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR039573	NS2A-like	Domain
A, B, C, D	IPR011181	Protein VP3, rotavirus	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.