Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad5avta2 All beta proteins Double-stranded beta-helix Metal cation-transporting ATPase, actuator domain A Metal cation-transporting ATPase, actuator domain A Sodium/potassium-transporting ATPase, actuator domain A (Squalus acanthias ) [TaxId: 7797 ], SCOPe (2.08)
Ad5avta3 Alpha and beta proteins (a/b) HAD-like HAD-like Meta-cation ATPase, catalytic domain P Sodium/potassium-transporting ATPase alpha chain (Squalus acanthias ) [TaxId: 7797 ], SCOPe (2.08)
Ad5avta4 Alpha and beta proteins (a+b) Metal cation-transporting ATPase, ATP-binding domain N Metal cation-transporting ATPase, ATP-binding domain N Metal cation-transporting ATPase, ATP-binding domain N Sodium/potassium-transporting ATPase alpha chain (Squalus acanthias ) [TaxId: 7797 ], SCOPe (2.08)
Ad5avta1 Membrane and cell surface proteins and peptides Metal cation-transporting ATPase, transmembrane domain Metal cation-transporting ATPase, transmembrane domain Metal cation-transporting ATPase, transmembrane domain Sodium/potassium-transporting ATPase, transmembrane domain (Squalus acanthias ) [TaxId: 7797 ], SCOPe (2.08)
Bd5avtb2 All beta proteins Immunoglobulin-like beta-sandwich Sodium/potassium-transporting ATPase, beta subunit extracellular domain Sodium/potassium-transporting ATPase, beta subunit extracellular domain Sodium/potassium-transporting ATPase, beta subunit extracellular domain (Squalus acanthias ) [TaxId: 7797 ], SCOPe (2.08)
Bd5avtb1 Membrane and cell surface proteins and peptides Single transmembrane helix Sodium/potassium-transporting ATPase, beta subunit transmembrane helix Sodium/potassium-transporting ATPase, beta subunit transmembrane helix Sodium/potassium-transporting ATPase, beta subunit transmembrane helix (Squalus acanthias ) [TaxId: 7797 ], SCOPe (2.08)
C [auth G]d5avtg_ Membrane and cell surface proteins and peptides Single transmembrane helix ATP1G1/PLM/MAT8-like (FXYD-like) ATP1G1/PLM/MAT8-like (FXYD-like) Phospholemman-like protein, FXYD10 (Squalus acanthias ) [TaxId: 7797 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AE1-E2_ATPase_Ne5avtA1 A: beta sandwichesX: jelly-rollH: Calcium ATPase, transduction domain A (From Topology)T: Calcium ATPase, transduction domain AF: E1-E2_ATPase_NECOD (1.6)
ACation_ATPase_Ce5avtA3 A: alpha bundlesX: Calcium ATPase transmembrane domain-related (From Homology)H: Calcium ATPase transmembrane domain-relatedT: Calcium ATPase transmembrane domain MF: Cation_ATPase_CECOD (1.6)
ACation_ATPasee5avtA4 A: a+b complex topologyX: Metal cation-transporting ATPase, ATP-binding domain (From Topology)H: Metal cation-transporting ATPase, ATP-binding domain (From Topology)T: Metal cation-transporting ATPase, ATP-binding domainF: Cation_ATPaseECOD (1.6)
AHydrolase_3_1e5avtA2 A: a/b three-layered sandwichesX: HAD domain-likeH: HAD domain-relatedT: HAD-likeF: Hydrolase_3_1ECOD (1.6)
BNa_K-ATPase_Ce5avtB2 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Na_K-ATPase_CECOD (1.6)
BNa_K-ATPase_Ne5avtB1 A: extended segmentsX: Transmembrane helix in sodium-potassium ATPase beta subunit (From Topology)H: Transmembrane helix in sodium-potassium ATPase beta subunit (From Topology)T: Transmembrane helix in sodium-potassium ATPase beta subunitF: Na_K-ATPase_NECOD (1.6)
C [auth G]ATP1G1_PLM_MAT8e5avtG1 A: extended segmentsX: FXYD family (From Topology)H: FXYD family (From Topology)T: FXYD familyF: ATP1G1_PLM_MAT8ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00689Cation transporting ATPase, C-terminus (Cation_ATPase_C)Cation transporting ATPase, C-terminus- Family
PF00702haloacid dehalogenase-like hydrolase (Hydrolase)haloacid dehalogenase-like hydrolaseThis family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted fo ...This family is structurally different from the alpha/beta hydrolase family (Pfam:PF00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain [1]. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria [2].
Domain
PF00690Cation transporter/ATPase, N-terminus (Cation_ATPase_N)Cation transporter/ATPase, N-terminusMembers of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.Domain
PF00122E1-E2 ATPase (E1-E2_ATPase)E1-E2 ATPase- Family
PF13246Cation transport ATPase (P-type) (Cation_ATPase)Cation transport ATPase (P-type)- Family
C [auth G]PF02038ATP1G1/PLM/MAT8 family (ATP1G1_PLM_MAT8)ATP1G1/PLM/MAT8 family- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Na, K-ATPase alpha subunit
Na+,K+-ATPase beta subunit
C [auth G]Phospholemman-like protein

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage