5AX3

Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors.

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Protein kinase-like (PK-like)	8036635	3000066	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e5ax3A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Mitogen-activated protein kinase 1	phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity MAP kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups phosphatase binding enzyme binding RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat kinase activity identical protein binding protein serine kinase activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process pyrimidine-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process small molecule metabolic process metabolic process primary metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process pyrimidine nucleobase metabolic process pyrimidine-containing compound metabolic process nucleobase-containing small molecule metabolic process nucleobase metabolic process small molecule metabolic process metabolic process primary metabolic process cytosine metabolic process developmental process multicellular organismal process tube development animal organ development respiratory tube development multicellular organism development anatomical structure morphogenesis anatomical structure development lung morphogenesis lung development respiratory system development animal organ morphogenesis system development regulation of cellular process intracellular receptor signaling pathway response to lipid signaling hormone-mediated signaling pathway intracellular signal transduction cell communication cellular response to endogenous stimulus response to hormone response to steroid hormone androgen receptor signaling pathway signal transduction nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus regulation of biological process response to endogenous stimulus biological regulation cellular response to organic cyclic compound cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway apoptotic process cell death programmed cell death protein phosphorylation phosphorylation cellular metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation cell surface receptor signaling pathway insulin-like growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway enzyme-linked receptor protein signaling pathway regulation of cellular component organization Golgi inheritance organelle inheritance regulation of organelle organization cellular component organization regulation of Golgi organization organelle organization regulation of Golgi inheritance cellular component organization or biogenesis Golgi organization endomembrane system organization ERBB signaling pathway ear morphogenesis embryonic organ morphogenesis ear development sensory organ development embryonic morphogenesis embryo development outer ear morphogenesis sensory organ morphogenesis embryonic organ development positive regulation of locomotion regulation of cell motility macrophage migration positive regulation of chemotaxis positive regulation of cell migration taxis cell migration regulation of immune system process regulation of mononuclear cell migration positive regulation of immune system process chemotaxis regulation of leukocyte chemotaxis positive regulation of macrophage migration regulation of leukocyte migration response to external stimulus positive regulation of leukocyte chemotaxis granulocyte migration leukocyte migration regulation of response to stimulus regulation of locomotion regulation of response to external stimulus macrophage chemotaxis positive regulation of biological process positive regulation of response to stimulus regulation of granulocyte chemotaxis regulation of macrophage migration positive regulation of response to external stimulus positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration cell motility locomotion positive regulation of cellular process cell chemotaxis regulation of macrophage chemotaxis positive regulation of leukocyte migration regulation of chemotaxis immune system process granulocyte chemotaxis mononuclear cell migration positive regulation of macrophage chemotaxis leukocyte chemotaxis ERBB2 signaling pathway ERBB2-ERBB3 signaling pathway ERBB3 signaling pathway regulation of protein stability regulation of biological quality response to epidermal growth factor response to growth factor positive regulation of organelle organization telomere organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process regulation of primary metabolic process telomere maintenance via telomere lengthening positive regulation of metabolic process positive regulation of telomere maintenance via telomere lengthening positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process DNA metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening positive regulation of chromosome organization telomere maintenance biosynthetic process positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase regulation of macromolecule biosynthetic process DNA biosynthetic process regulation of metabolic process regulation of DNA metabolic process regulation of telomere maintenance positive regulation of cellular component organization cellular biosynthetic process positive regulation of cellular metabolic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of biosynthetic process telomere maintenance via telomerase chromosome organization positive regulation of DNA biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulation of telomere maintenance via telomerase regulation of cellular biosynthetic process positive regulation of cellular biosynthetic process trans-synaptic signaling synaptic signaling anterograde trans-synaptic signaling cell-cell signaling chemical synaptic transmission peptidyl-serine modification peptidyl-serine phosphorylation progesterone receptor signaling pathway regulation of developmental process cellular developmental process negative regulation of developmental process negative regulation of biological process regulation of cell differentiation cell differentiation negative regulation of cellular process negative regulation of cell differentiation response to nutrient levels cellular response to amino acid starvation cellular response to starvation cellular response to nutrient levels response to amino acid starvation response to starvation cellular response to metal ion response to metal ion cellular response to cadmium ion response to cadmium ion head development face development immune response-regulating cell surface receptor signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway regulation of immune response antigen receptor-mediated signaling pathway activation of immune response labyrinthine layer blood vessel development placenta blood vessel development placenta development chordate embryonic development labyrinthine layer development in utero embryonic development vasculature development circulatory system development embryonic placenta development embryo development ending in birth or egg hatching blood vessel development T cell receptor signaling pathway immune system development gland development hematopoietic or lymphoid organ development thymus development thyroid gland development endocrine system development stress-activated MAPK cascade stress-activated protein kinase signaling cascade intracellular signaling cassette MAPK cascade localization import into cell transport endocytosis caveolin-mediated endocytosis establishment of localization vesicle-mediated transport positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-threonine phosphorylation positive regulation of phosphate metabolic process positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-threonine phosphorylation regulation of protein metabolic process regulation of phosphorus metabolic process regulation of phosphorylation ERK1 and ERK2 cascade response to dsRNA response to nitrogen compound response to exogenous dsRNA peripheral nervous system development cell development nervous system development glial cell development neurogenesis Schwann cell development gliogenesis glial cell differentiation Schwann cell differentiation biological process involved in interspecies interaction between organisms cellular response to lipopolysaccharide response to biotic stimulus lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to external biotic stimulus response to other organism response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to molecule of bacterial origin ossification regulation of multicellular organismal process regulation of ossification regulation of cytoskeleton organization cytoskeleton organization epithelium development cell population proliferation mammary gland development tissue development mammary gland epithelium development epithelial cell proliferation mammary gland epithelial cell proliferation regulation of cellular response to stress regulation of signal transduction regulation of intracellular signal transduction regulation of response to stress regulation of signaling regulation of stress-activated protein kinase signaling cascade regulation of MAPK cascade regulation of stress-activated MAPK cascade regulation of cell communication trachea morphogenesis trachea formation trachea development anatomical structure formation involved in morphogenesis animal organ formation regulation of localization cellular localization regulation of transport intracellular transport regulation of vesicle-mediated transport endosomal transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport early endosome to late endosome transport regulation of cellular localization establishment of localization in cell regulation of intracellular transport astrocyte differentiation central nervous system development Bergmann glial cell differentiation response to peptide cellular response to tumor necrosis factor response to cytokine cellular response to cytokine stimulus response to tumor necrosis factor homeostatic process cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress regulation of leukocyte proliferation positive regulation of cell population proliferation leukocyte proliferation macrophage proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation positive regulation of macrophage proliferation regulation of macrophage proliferation cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway cellular response to peptide hormone stimulus response to insulin cellular response to insulin stimulus stem cell development heart development neural crest cell differentiation cardiac neural crest cell development involved in heart development neural crest cell development mesenchyme development cardiocyte differentiation stem cell differentiation cardiac neural crest cell differentiation involved in heart development mesenchymal cell differentiation behavior system process learning or memory nervous system process cognition myelination axon ensheathment ensheathment of neurons positive regulation of telomere capping telomere capping regulation of telomere capping response to nicotine positive regulation of cell communication modulation of chemical synaptic transmission long-term synaptic potentiation regulation of synaptic plasticity positive regulation of synaptic transmission regulation of trans-synaptic signaling positive regulation of signaling	cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system cytoskeleton cell projection pseudopodium cellular anatomical entity plasma membrane bounded cell projection intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum mitochondrion anchoring junction cell junction focal adhesion cell-substrate junction centrosome microtubule organizing center microtubule cytoskeleton membrane microdomain cell periphery membrane raft plasma membrane raft membrane plasma membrane plasma membrane region caveola lytic vacuole intracellular vesicle cytoplasmic vesicle lumen vacuolar lumen cytoplasmic vesicle vesicle lysosome vesicle lumen azurophil granule vacuole secretory granule lumen azurophil granule lumen secretory granule primary lysosome secretory vesicle mitotic spindle spindle ficolin-1-rich granule ficolin-1-rich granule lumen nucleus nucleoplasm nuclear lumen early endosome endosome extracellular region synapse late endosome
B	allosteric and ATP-competitive inhibitor	RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding primary miRNA binding protein phosphatase binding phosphatase binding protein binding enzyme binding DNA binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding primary miRNA binding protein phosphatase binding phosphatase binding protein binding enzyme binding DNA binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity signaling receptor binding protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity identical protein binding protein homodimerization activity kinase binding protein kinase binding chromatin binding chromatin DNA binding transcription factor binding DNA-binding transcription factor binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding transcription regulatory region nucleic acid binding nuclear receptor activity molecular transducer activity ligand-activated transcription factor activity signaling receptor activity RNA polymerase II-specific DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular sequestering activity RNA sequestering activity	regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process regulation of response to wounding response to stress regulation of response to stress response to wounding regulation of biological process regulation of inflammatory response to wounding defense response negative regulation of response to stimulus biological regulation regulation of defense response response to stimulus regulation of response to external stimulus negative regulation of inflammatory response negative regulation of biological process regulation of response to wounding response to stress regulation of response to stress response to wounding regulation of biological process regulation of inflammatory response to wounding defense response negative regulation of response to stimulus biological regulation response to external stimulus regulation of inflammatory response negative regulation of response to wounding negative regulation of inflammatory response to wounding regulation of response to stimulus negative regulation of response to external stimulus inflammatory response to wounding negative regulation of defense response inflammatory response negative regulation of stem cell differentiation developmental process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of developmental process regulation of cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation negative regulation of cellular process cellular process negative regulation of cell differentiation cellular response to stimulus cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway signaling cell communication signal transduction ribonucleotide catabolic process pyridine nucleotide catabolic process negative regulation of small molecule metabolic process negative regulation of glycolytic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process negative regulation of ATP metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process cellular metabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process primary metabolic process regulation of cellular metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process metabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process regulation of metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process positive regulation of macromolecule biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of miRNA transcription regulation of multicellular organism growth multicellular organismal process regulation of growth regulation of developmental growth developmental growth growth multicellular organism growth regulation of multicellular organismal process interleukin-15-mediated signaling pathway response to cytokine cellular response to interleukin-15 cytokine-mediated signaling pathway response to peptide response to chemical cellular response to cytokine stimulus response to interleukin-15 positive regulation of interleukin-8 production cytokine production regulation of cytokine production interleukin-8 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production regulation of interleukin-8 production cell surface receptor signaling pathway via JAK-STAT cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of vascular endothelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation vascular endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation positive regulation of vascular endothelial cell proliferation multicellular organism development anatomical structure development nervous system development system development mRNA transcription by RNA polymerase II mRNA transcription mRNA metabolic process transcription by RNA polymerase II interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production negative regulation of cellular catabolic process autophagy regulation of autophagy cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process process utilizing autophagic mechanism somatic stem cell population maintenance maintenance of cell number stem cell population maintenance cellular response to leptin stimulus cellular response to endogenous stimulus response to hormone response to leptin cellular response to hormone stimulus leptin-mediated signaling pathway response to endogenous stimulus cellular response to chemical stimulus negative regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process regulation of behavior behavior feeding behavior regulation of feeding behavior response to interleukin-9 interleukin-9-mediated signaling pathway cellular response to interleukin-9 cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway interleukin-23-mediated signaling pathway sexual reproduction reproductive process eating behavior multicellular organismal-level homeostasis homeostatic process energy homeostasis interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 interleukin-10-mediated signaling pathway positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion temperature homeostasis regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response negative regulation of gene expression negative regulation of locomotion negative regulation of neuron migration regulation of neuron migration neurogenesis negative regulation of cell migration neuron migration generation of neurons negative regulation of cell motility regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus cell surface receptor protein tyrosine kinase signaling pathway growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound response to growth hormone cellular response to interleukin-17 response to interleukin-17 protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport intracellular transport protein localization to nucleus establishment of localization localization import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity positive regulation of molecular function regulation of molecular function regulation of DNA-binding transcription factor activity cell development regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of metalloendopeptidase activity regulation of proteolysis proteolysis regulation of endopeptidase activity protein metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity regulation of metalloendopeptidase activity positive regulation of hydrolase activity regulation of metallopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis positive regulation of metallopeptidase activity sensory organ development photoreceptor cell differentiation visual system development eye morphogenesis neuron differentiation eye photoreceptor cell differentiation animal organ morphogenesis sensory system development eye development animal organ development anatomical structure morphogenesis sensory organ morphogenesis phosphorylation positive regulation of transcription by RNA polymerase II intracellular receptor signaling pathway intracellular signal transduction chemical homeostasis glucose homeostasis carbohydrate homeostasis post-transcriptional regulation of gene expression RNA processing regulation of miRNA processing primary miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing negative regulation of primary miRNA processing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing regulation of primary miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains immune response adaptive immune response T-helper 17 type immune response intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction interleukin-2-mediated signaling pathway cellular response to interleukin-2 response to interleukin-2 interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production gliogenesis glial cell differentiation radial glial cell differentiation astrocyte differentiation central nervous system development negative regulation of cell population proliferation angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis retina development in camera-type eye neural retina development camera-type eye morphogenesis camera-type eye photoreceptor cell differentiation retina morphogenesis in camera-type eye camera-type eye development retinal rod cell differentiation positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus regulation of signaling Notch signaling pathway regulation of Notch signaling pathway regulation of cell communication positive regulation of Notch signaling pathway positive regulation of signaling cell cycle regulation of cell cycle interleukin-11-mediated signaling pathway CD4-positive or CD8-positive, alpha-beta T cell lineage commitment mononuclear cell differentiation lymphocyte activation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response leukocyte activation alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response alpha-beta T cell activation T cell differentiation CD4-positive, alpha-beta T cell lineage commitment lymphocyte activation involved in immune response T-helper cell differentiation alpha-beta T cell lineage commitment cell activation T-helper cell lineage commitment T cell differentiation involved in immune response T cell lineage commitment immune effector process T-helper 17 cell lineage commitment positive T cell selection T cell selection T-helper 17 cell differentiation cell fate commitment leukocyte differentiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex transcription regulator complex intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane protein-containing complex transcription regulator complex intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site	Conserved Site
A	IPR000719	Protein kinase domain	Domain
A	IPR017441	Protein kinase, ATP binding site	Binding Site
A	IPR050117	Mitogen-activated protein kinase	Family
A	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A	IPR008349	Mitogen-activated protein (MAP) kinase, ERK1/2	Family
A	IPR008271	Serine/threonine-protein kinase, active site	Active Site
B	IPR048988	Signal transducer and activator of transcription, linker domain	Domain
B	IPR013800	STAT transcription factor, all-alpha domain	Domain
B	IPR035855	STAT3, SH2 domain	Domain
B	IPR036860	SH2 domain superfamily	Homologous Superfamily
B	IPR013799	STAT transcription factor, protein interaction	Domain
B	IPR015988	STAT transcription factor, coiled coil	Homologous Superfamily
B	IPR036535	STAT transcription factor, N-terminal domain superfamily	Homologous Superfamily
B	IPR000980	SH2 domain	Domain
B	IPR001217	Transcription factor STAT	Family
B	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
B	IPR013801	STAT transcription factor, DNA-binding	Domain
B	IPR012345	STAT transcription factor, DNA-binding, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P28482	trigeminal neuralgia squamous cell carcinoma substance withdrawal syndrome cardiomyopathy chromosome 22q11.2 deletion syndrome, distal female infertility head and neck cancer Neoplasm Metastasis brain ischemia Sezary syndrome cocaine abuse streptococcal pneumonia cocaine dependence extrahepatic cholestasis ovarian cancer trigeminal neuralgia squamous cell carcinoma substance withdrawal syndrome cardiomyopathy chromosome 22q11.2 deletion syndrome, distal female infertility head and neck cancer Neoplasm Metastasis brain ischemia Sezary syndrome cocaine abuse streptococcal pneumonia cocaine dependence extrahepatic cholestasis ovarian cancer juvenile idiopathic arthritis esophageal adenocarcinoma tuberculosis gastric neoplasm medulloblastoma neuronal ceroid lipofuscinosis 6 ovarian neoplasm psoriasis schizophrenia kidney neoplasm lung benign neoplasm malignant tumor of neck glioblastoma head and neck neoplasm neoplasm of neck amyotrophic lateral sclerosis osteosarcoma atypical teratoid rhabdoid tumor Pick disease breast cancer juvenile dermatomyositis large cell medulloblastoma gastric cancer hereditary diffuse gastric adenocarcinoma bipolar disorder primitive neuroectodermal tumor cancer IgA glomerulonephritis kidney cancer
B	Pharos: P40763	Hyper-IgE recurrent infection syndrome 1 psoriasis Crohn disease STAT3-related early-onset multisystem autoimmune disease ulcerative colitis adult T-cell leukemia/lymphoma anaplastic large cell lymphoma autoimmune disease acute myeloid leukemia cardiomyopathy T-cell leukemia prostate cancer medulloblastoma squamous cell carcinoma T-cell non-Hodgkin lymphoma Hyper-IgE recurrent infection syndrome 1 psoriasis Crohn disease STAT3-related early-onset multisystem autoimmune disease ulcerative colitis adult T-cell leukemia/lymphoma anaplastic large cell lymphoma autoimmune disease acute myeloid leukemia cardiomyopathy T-cell leukemia prostate cancer medulloblastoma squamous cell carcinoma T-cell non-Hodgkin lymphoma tubular adenocarcinoma Copper-Overload Cirrhosis medullomyoblastoma with myogenic differentiation sarcomatoid carcinoma liver cancer non-small cell lung carcinoma malignant colon neoplasm ovarian cancer breast carcinoma melanotic medulloblastoma juvenile idiopathic arthritis cervical cancer atherosclerosis brain ischemia adenocarcinoma carcinoma adult medulloblastoma middle cerebral artery infarction childhood medulloblastoma granular cell carcinoma hematopoietic and lymphoid system neoplasm astrocytic tumor lymphatic system disease colonic neoplasm osteosarcoma atopic eczema malignant glioma congenital diaphragmatic hernia ovarian neoplasm pancreatic neoplasm atypical teratoid rhabdoid tumor undifferentiated carcinoma pituitary cancer B cell deficiency cribriform carcinoma of breast acquired metabolic disease breast cancer depressive disorder prostate disease inflammatory bowel disease pulmonary fibrosis gastric neoplasm arteriosclerosis disorder head and neck squamous cell carcinoma T-cell large granular lymphocyte leukemia lung disease colitis hepatitis combined immunodeficiency due to DOCK8 deficiency type 1 diabetes mellitus pancreatic ductal adenocarcinoma permanent neonatal diabetes mellitus herpes zoster craniosynostosis plasma cell myeloma benign colon neoplasm idiopathic interstitial pneumonia desmoplastic/nodular medulloblastoma acute T cell leukemia ischemia reperfusion injury cancer rheumatoid arthritis kidney disease skin disease liver disease glioblastoma arthritic joint disease lung adenocarcinoma hematologic disease colonic disease obesity disorder malignant ependymoma ovarian disease hereditary diffuse gastric adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm pilocytic astrocytoma autoimmune lymphoproliferative syndrome vertebral column disease malignant pancreatic neoplasm cribriform carcinoma precancerous condition hyper-IgE syndrome mammary neoplasms, animal breast disease diabetes mellitus pustulosis palmaris et plantaris gastric cancer ankylosing spondylitis liver neoplasm stomach disease lung cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.