5CIM

Structure of Mycobacterium thermoresistibile GlgE in complex with maltose (cocrystallisation with maltose-1-phosphate) at 3.32A resolution

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DUF3416	e5cimA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF3416	ECOD (1.6)
A	Malt_amylase_C_6	e5cimA3	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Malt_amylase_C_6	ECOD (1.6)
A	Alpha-amylase	e5cimA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Alpha-amylase	ECOD (1.6)
B	DUF3416	e5cimB3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: DUF3416	ECOD (1.6)
B	Malt_amylase_C_6	e5cimB1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: Glycosyl hydrolase domain (From Topology)	T: Glycosyl hydrolase domain	F: Malt_amylase_C_6	ECOD (1.6)
B	Alpha-amylase	e5cimB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Alpha-amylase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
A	1.20.58.80	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
B	1.20.58.80	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF11896	Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S (GlgE_dom_N_S)	Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S	-	Family
A, B	PF00128	Alpha amylase, catalytic domain (Alpha-amylase)	Alpha amylase, catalytic domain	Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, a ...	Alpha amylase is classified as family 13 of the glycosyl hydrolases. The structure is an 8 stranded alpha/beta barrel containing the active site, interrupted by a ~70 a.a. calcium-binding domain protruding between beta strand 3 and alpha helix 3, and a carboxyl-terminal Greek key beta-barrel domain.	Domain
A, B	PF21702	GLGE, C-terminal (GLGE_C)	GLGE, C-terminal	This entry represents the C-terminal domain of alpha-1,4-glucan:maltose-1-phosphate maltosyltransferases (GLGE) which has an all-beta fold [1-5]. This domain, referred to domain C, together with the catalytic one, is involved in the binding of alpha- ...	This entry represents the C-terminal domain of alpha-1,4-glucan:maltose-1-phosphate maltosyltransferases (GLGE) which has an all-beta fold [1-5]. This domain, referred to domain C, together with the catalytic one, is involved in the binding of alpha-glucan chains [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase	glycosyltransferase activity transferase activity hexosyltransferase activity catalytic activity hydrolase activity, acting on glycosyl bonds hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity	carbohydrate metabolic process glucan biosynthetic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process primary metabolic process macromolecule biosynthetic process alpha-glucan metabolic process polysaccharide metabolic process glucan metabolic process biosynthetic process alpha-glucan biosynthetic process metabolic process carbohydrate metabolic process glucan biosynthetic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process primary metabolic process macromolecule biosynthetic process alpha-glucan metabolic process polysaccharide metabolic process glucan metabolic process biosynthetic process alpha-glucan biosynthetic process metabolic process cellular process macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006047	Glycosyl hydrolase, family 13, catalytic domain	Domain
A, B	IPR049171	Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, C-terminal	Domain
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A, B	IPR021828	Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase, domain N/S	Domain
A, B	IPR013780	Glycosyl hydrolase, all-beta	Homologous Superfamily
A, B	IPR026585	Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.