5CKX

Non-covalent complex of DAHP synthase and chorismate mutase from Mycobacterium tuberculosis with bound transition state analog and feedback effectors tyrosine and phenylalanine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5ckxb_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class-II DAHP synthetase	automated matches	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
A	d5ckxa_	Alpha and beta proteins (a/b)	TIM beta/alpha-barrel	Aldolase	Class-II DAHP synthetase	automated matches	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Aldolase	8037699	3000445	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Aldolase	8037699	3000445	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	DAHP_synth_2	e5ckxB1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: DAHP_synth_2	ECOD (1.6)
A	DAHP_synth_2	e5ckxA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: DAHP_synth_2	ECOD (1.6)
D	CM_2	e5ckxD1	A: alpha bundles	X: Chorismate mutase II (From Topology)	H: Chorismate mutase II (From Topology)	T: Chorismate mutase II	F: CM_2	ECOD (1.6)
C	CM_2	e5ckxC1	A: alpha bundles	X: Chorismate mutase II (From Topology)	H: Chorismate mutase II (From Topology)	T: Chorismate mutase II	F: CM_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D	1.20.59.10	Mainly Alpha	Up-down Bundle	Chorismate Mutase Domain, subunit A	Chorismate mutase	CATH (4.3.0)
C	1.20.59.10	Mainly Alpha	Up-down Bundle	Chorismate Mutase Domain, subunit A	Chorismate mutase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01474	Class-II DAHP synthetase family (DAHP_synth_2)	Class-II DAHP synthetase family	Members of this family are aldolase enzymes that catalyse the first step of the shikimate pathway.	Domain
C, D	PF01817	Chorismate mutase type II (CM_2)	Chorismate mutase type II	Chorismate mutase EC:5.4.99.5 catalyses the conversion of chorismate to prephenate in the pathway of tyrosine and phenylalanine biosynthesis. This enzyme is negatively regulated by tyrosine, tryptophan and phenylalanine [2,3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Phospho-2-dehydro-3-deoxyheptonate aldolase AroG	cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding transferase activity 3-deoxy-7-phosphoheptulonate synthase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity	amino acid biosynthetic process biosynthetic process amino acid metabolic process primary metabolic process metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis amino acid biosynthetic process biosynthetic process amino acid metabolic process primary metabolic process metabolic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization cellular process cellular component organization or biogenesis small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process chorismate metabolic process chorismate biosynthetic process small molecule metabolic process dicarboxylic acid biosynthetic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery plasma membrane membrane external encapsulating structure cell wall peptidoglycan-based cell wall
C, D	Intracellular chorismate mutase	isomerase activity chorismate mutase activity catalytic activity intramolecular transferase activity	aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process aromatic amino acid family biosynthetic process, prephenate pathway biosynthetic process aromatic amino acid family biosynthetic process aromatic amino acid metabolic process small molecule biosynthetic process oxoacid metabolic process cellular biosynthetic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process aromatic amino acid family biosynthetic process, prephenate pathway biosynthetic process small molecule metabolic process metabolic process cellular process amino acid biosynthetic process monocarboxylic acid biosynthetic process benzene-containing compound metabolic process salicylic acid biosynthetic process organic hydroxy compound metabolic process salicylic acid metabolic process organic hydroxy compound biosynthetic process phenol-containing compound metabolic process phenol-containing compound biosynthetic process monocarboxylic acid metabolic process dicarboxylic acid metabolic process chorismate metabolic process	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002480	DAHP synthetase, class II	Family
A, B	IPR013785	Aldolase-type TIM barrel	Homologous Superfamily
C, D	IPR036979	Chorismate mutase domain superfamily	Homologous Superfamily
C, D	IPR010958	Chorismate mutase, high GC Gram-positive bacteria/archaeal	Domain
C, D	IPR051331	Chorismate mutase-related enzymes	Family
C, D	IPR002701	Chorismate mutase II, prokaryotic-type	Domain
C, D	IPR036263	Chorismate mutase type II superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.