Annotations: 5CXY

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Sialyltransferase/TPK catalytic domain-like	8053227	3000683	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sialyltransferase/TPK catalytic domain-like	8053227	3000683	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_transf_29	e5cxyA1	A: a/b three-layered sandwiches	X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	T: Alpha-2,3/8-sialyltransferase CstII-related	F: Glyco_transf_29	ECOD (1.6)
B	Glyco_transf_29	e5cxyB1	A: a/b three-layered sandwiches	X: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	H: Alpha-2,3/8-sialyltransferase CstII-related (From Topology)	T: Alpha-2,3/8-sialyltransferase CstII-related	F: Glyco_transf_29	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.1480.20	Alpha Beta	Alpha-Beta Complex	sialyltransferase cstii, chain A	Glycosyl transferase family 29	CATH (4.3.0)
B	3.90.1480.20	Alpha Beta	Alpha-Beta Complex	sialyltransferase cstii, chain A	Glycosyl transferase family 29	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00777	Glycosyltransferase family 29 (sialyltransferase) (Glyco_transf_29)	Glycosyltransferase family 29 (sialyltransferase)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase	sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding glycosyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity sialyltransferase activity transferase activity catalytic activity identical protein binding sialic acid binding organic acid binding binding ion binding anion binding carboxylic acid binding carbohydrate derivative binding small molecule binding glycosyltransferase activity alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity sialyltransferase activity transferase activity catalytic activity identical protein binding protein binding	carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process carbohydrate derivative biosynthetic process glycoprotein biosynthetic process carbohydrate derivative metabolic process primary metabolic process glycoprotein metabolic process protein glycosylation macromolecule biosynthetic process biosynthetic process glycosylation macromolecule modification macromolecule glycosylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process carbohydrate metabolic process oligosaccharide metabolic process sphingolipid biosynthetic process glycolipid metabolic process lipid biosynthetic process ganglioside biosynthetic process amide metabolic process ceramide metabolic process membrane lipid metabolic process glycosphingolipid metabolic process liposaccharide metabolic process amide biosynthetic process sphingolipid metabolic process glycolipid biosynthetic process ceramide biosynthetic process glycosphingolipid biosynthetic process membrane lipid biosynthetic process ganglioside metabolic process lipid metabolic process N-glycan processing sialylation	membrane-bounded organelle Golgi membrane intracellular anatomical structure Golgi apparatus membrane intracellular membrane-bounded organelle endomembrane system intracellular organelle bounding membrane of organelle cellular anatomical structure organelle cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR050943	Glycosyltransferase 29 (Sialyltransferase)	Family
A, B	IPR012163	Sialyltransferase	Family
A, B	IPR001675	Glycosyl transferase family 29	Family
A, B	IPR038578	GT29-like superfamiliy	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O43173	astrocytic tumor large cell medulloblastoma malignant glioma Pick disease atypical teratoid rhabdoid tumor lung carcinoma medulloblastoma pilocytic astrocytoma glioblastoma malignant ependymoma oligodendroglioma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.