Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyMacro domain-like 8075150 3000458 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AMacro_3e5dusA1 A: a/b three-layered sandwichesX: Macro domain-like (From Topology)H: Macro domain-like (From Topology)T: Macro domain-likeF: Macro_3ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.220.10 Alpha Beta 3-Layer(aba) Sandwich Leucine Aminopeptidase, subunit E domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF01661Macro domain (Macro)Macro domainThe Macro or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose (an NAD metabolite) or related ligands. Binding to ADP-ribose could be either covalent or non-covalent [1]: in certain cases it is believed to bind non-covalently ...The Macro or A1pp domain is a module of about 180 amino acids which can bind ADP-ribose (an NAD metabolite) or related ligands. Binding to ADP-ribose could be either covalent or non-covalent [1]: in certain cases it is believed to bind non-covalently [2]; while in other cases (such as Aprataxin) it appears to bind both non-covalently through a zinc finger motif, and covalently through a separate region of the protein [3]. This domain is found in a number of otherwise unrelated proteins. It is found at the C-terminus of the macro-H2A histone protein 4 and also in the non-structural proteins of several types of ssRNA viruses such as NSP3 from alpha-viruses and coronaviruses. This domain is also found on its own in a family of proteins from bacteria, archaebacteria and eukaryotes. The 3D structure of the SARS-CoV Macro domain has a mixed alpha/beta fold consisting of a central seven-stranded twisted mixed beta sheet sandwiched between two alpha helices on one face, and three on the other. The final alpha-helix, located on the edge of the central beta-sheet, forms the C terminus of the protein [4]. The crystal structure of AF1521 (a Macro domain-only protein from Archaeoglobus fulgidus) has also been reported and compared with other Macro domain containing proteins. Several Macro domain only proteins are shorter than AF1521, and appear to lack either the first strand of the beta-sheet or the C-terminal helix 5. Well conserved residues form a hydrophobic cleft and cluster around the AF1521-ADP-ribose binding site [5].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
ORF1a

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR022733DPUP/SUD, C-terminal, betacoronavirusDomain
IPR043611Coronavirus replicase NSP3, C-terminalDomain
IPR038123Non-structural protein NSP4, C-terminal superfamily, coronavirusHomologous Superfamily
IPR042570Non-structural protein NSP3, nucleic acid-binding domain superfamily, betacoronavirusHomologous Superfamily
IPR047566Coronavirus replicase NSP3, Y domainDomain
IPR043178Papain-like protease, thumb domain superfamily, coronavirusHomologous Superfamily
IPR044388Non-structural protein 2, MERS-CoV-likeDomain
IPR043612Non-structural protein NSP4, N-terminal, coronavirusDomain
IPR044353NSP3, second ubiquitin-like (Ubl) domain, coronavirusDomain
IPR009003Peptidase S1, PA clanHomologous Superfamily
IPR044382NSP3, SUD-C domain, MERS-CoV-likeDomain
IPR013016Peptidase C16, coronavirusDomain
IPR037204Non-structural protein NSP7 superfamily, coronavirusHomologous Superfamily
IPR044357NSP3, first ubiquitin-like (Ubl) domain, coronavirusDomain
IPR046443NSP1, globular domain, alpha/betacoronavirusDomain
IPR043610Non-structural protein 6, coronavirusDomain
IPR043477Peptidase C30, domain 3, coronavirusHomologous Superfamily
IPR018995RNA synthesis protein NSP10, coronavirusDomain
IPR038400Non-structural protein NSP3, SUD-M domain superfamily, betacoronavirusHomologous Superfamily
IPR046442NSP1, C-terminal domain, betacoronavirusDomain
IPR043615Nonstructural protein 2, N-terminal domain, coronavirusDomain
IPR043177Papain-like protease, N-terminal domain superfamily, coronavirusHomologous Superfamily
IPR014822Non-structural protein NSP9, coronavirusDomain
IPR021590NSP1, globular domain, betacoronavirusDomain
IPR024375Non-structural protein NSP3, SUD-M domain, betacoronavirusDomain
IPR044367Non-structural protein 6, betacoronavirusDomain
IPR037230Non-structural protein NSP8 superfamily, coronavirusHomologous Superfamily
IPR014828Non-structural protein NSP7, coronavirusDomain
IPR032505Non-structural protein NSP4, C-terminal, coronavirusDomain
IPR043503Papain-like viral protease, palm and finger domains, coronavirusHomologous Superfamily
IPR014829Non-structural protein NSP8, coronavirusDomain
IPR036499Non-structural protein NSP9 superfamily, coronavirusHomologous Superfamily
IPR002589Macro domainDomain
IPR047567Non-structural protein NSP3, group 2-specific marker domain, betacoronavirusDomain
IPR008740Peptidase C30, coronavirusDomain
IPR036333RNA synthesis protein NSP10 superfamily, coronavirusHomologous Superfamily
IPR047573Non-structural protein 2, middle domain, coronavirusDomain
IPR049894Coronavirus NSP3, 3Ecto domainDomain
IPR043472Macro domain-likeHomologous Superfamily
IPR044371Non-structural protein 3, X-domain-likeDomain
IPR032592Non-structural protein NSP3, nucleic acid-binding domain, betacoronavirusDomain
IPR043613Non-structural protein 2, C-terminal domain, coronavirusDomain
IPR038083Non-structural protein NSP3A domain-like superfamilyHomologous Superfamily
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily