5DVX

Crystal structure of the catalytic-domain of human carbonic anhydrase IX at 1.6 angstrom resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5dvxa_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5dvxb_	All beta proteins	Carbonic anhydrase	Carbonic anhydrase	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Carbonic anhydrase	8065103	3001672	SCOP2B (2022-06-29)
B	SCOP2 Family	Carbonic anhydrase	8065102	4002732	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Carbonic anhydrase	8065103	3001672	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Carb_anhydrase	e5dvxA1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)
B	Carb_anhydrase	e5dvxB1	A: beta meanders	X: Carbonic anhydrase (From Topology)	H: Carbonic anhydrase (From Topology)	T: Carbonic anhydrase	F: Carb_anhydrase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)
B	3.10.200.10	Alpha Beta	Roll	Carbonic Anhydrase II	Alpha carbonic anhydrase	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00194	Eukaryotic-type carbonic anhydrase (Carb_anhydrase)	Eukaryotic-type carbonic anhydrase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Carbonic anhydrase 9	molecular function activator activity molecular function regulator activity cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding carbonate dehydratase activity hydro-lyase activity lyase activity catalytic activity carbon-oxygen lyase activity	response to stimulus response to chemical response to xenobiotic stimulus localization secretion transport establishment of localization cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process developmental process tissue morphogenesis response to stimulus response to chemical response to xenobiotic stimulus localization secretion transport establishment of localization cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process developmental process tissue morphogenesis anatomical structure morphogenesis epithelium development anatomical structure development morphogenesis of an epithelium tissue development response to decreased oxygen levels response to hypoxia response to stress response to oxygen levels response to abiotic stimulus response to ketone response to lipid response to oxygen-containing compound response to testosterone response to organic cyclic compound	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane plasma membrane plasma membrane bounded cell projection cell periphery cell projection actin-based cell projection plasma membrane region microvillus microvillus membrane cell projection membrane basal part of cell basal plasma membrane basolateral plasma membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018338	Carbonic anhydrase, alpha-class, conserved site	Conserved Site
A, B	IPR001148	Alpha carbonic anhydrase domain	Domain
A, B	IPR036398	Alpha carbonic anhydrase domain superfamily	Homologous Superfamily
A, B	IPR023561	Carbonic anhydrase, alpha-class	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q16790	chronic myelogenous leukemia, BCR-ABL1 positive Anaplasia pulmonary hypertension psoriasis malignant colon neoplasm malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm breast ductal adenocarcinoma ductal breast carcinoma in situ malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis cancer kidney disease chronic myelogenous leukemia, BCR-ABL1 positive Anaplasia pulmonary hypertension psoriasis malignant colon neoplasm malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm breast ductal adenocarcinoma ductal breast carcinoma in situ malignant ependymoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis cancer kidney disease malignant mesothelioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.