5FBG

S1 nuclease from Aspergillus oryzae, mutant D65N, in complex with phosphate, 2'-deoxycytidine and 2'-deoxyguanosine.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5fbgb_	All alpha proteins	Phospholipase C/P1 nuclease	Phospholipase C/P1 nuclease	automated matches	automated matches	Yellow koji mold (Aspergillus oryzae RIB40 ) [TaxId: 510516 ],	SCOPe (2.08)
A	d5fbga_	All alpha proteins	Phospholipase C/P1 nuclease	Phospholipase C/P1 nuclease	automated matches	automated matches	Yellow koji mold (Aspergillus oryzae RIB40 ) [TaxId: 510516 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Phospholipase C/P1 nuclease	8079027	3001513	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Phospholipase C/P1 nuclease	8079027	3001513	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	S1-P1_nuclease	e5fbgB1	A: alpha bundles	X: Phospholipase C/P1 nuclease (From Topology)	H: Phospholipase C/P1 nuclease (From Topology)	T: Phospholipase C/P1 nuclease	F: S1-P1_nuclease	ECOD (1.6)
A	S1-P1_nuclease	e5fbgA1	A: alpha bundles	X: Phospholipase C/P1 nuclease (From Topology)	H: Phospholipase C/P1 nuclease (From Topology)	T: Phospholipase C/P1 nuclease	F: S1-P1_nuclease	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.10.575.10	Mainly Alpha	Orthogonal Bundle	P1 Nuclease	P1 Nuclease	CATH (4.3.0)
A	1.10.575.10	Mainly Alpha	Orthogonal Bundle	P1 Nuclease	P1 Nuclease	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02265	S1/P1 Nuclease (S1-P1_nuclease)	S1/P1 Nuclease	This family contains both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Nuclease S1	binding organic cyclic compound binding nucleic acid binding nuclease activity hydrolase activity, acting on ester bonds hydrolase activity catalytic activity endonuclease activity cation binding ion binding metal ion binding small molecule binding	catabolic process primary metabolic process DNA metabolic process nucleic acid metabolic process macromolecule catabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process DNA catabolic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR003154	S1/P1 nuclease	Family
A, B	IPR008947	Phospholipase C/P1 nuclease domain superfamily	Homologous Superfamily
A, B	IPR023827	Peptidase S8, subtilisin, Asp-active site	Active Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.