5GI9

Crystal Structure of Drosophila melanogaster Dopamine N-Acetyltransferase in Ternary Complex with CoA and Acetyl-Tryptamine

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acetyltransf_10_5	e5gi9A1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13673	Acetyltransferase (GNAT) domain (Acetyltransf_10)	Acetyltransferase (GNAT) domain	This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dopamine N-acetyltransferase	acetyltransferase activity N-acetyltransferase activity acyltransferase activity arylamine N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity N-acyltransferase activity aralkylamine N-acetyltransferase activity	multicellular organismal process sleep developmental process chitin-based cuticle sclerotization molting cycle molting cycle process molting cycle, chitin-based cuticle developmental maturation amine metabolic process catecholamine metabolic process phenol-containing compound metabolic process organic hydroxy compound metabolic process metabolic process cellular process multicellular organismal process sleep developmental process chitin-based cuticle sclerotization molting cycle molting cycle process molting cycle, chitin-based cuticle developmental maturation amine metabolic process catecholamine metabolic process phenol-containing compound metabolic process organic hydroxy compound metabolic process metabolic process cellular process catechol-containing compound metabolic process biogenic amine metabolic process regulation of hormone levels biological regulation indole-containing compound metabolic process amide biosynthetic process hormone metabolic process melatonin metabolic process biosynthetic process indole-containing compound biosynthetic process amide metabolic process regulation of biological quality melatonin biosynthetic process hormone biosynthetic process alcohol catabolic process catabolic process ethanolamine-containing compound metabolic process alcohol metabolic process biogenic amine catabolic process octopamine metabolic process phenol-containing compound catabolic process octopamine catabolic process organic hydroxy compound catabolic process small molecule metabolic process small molecule catabolic process amine catabolic process rhythmic process circadian sleep/wake cycle, sleep circadian sleep/wake cycle regulation of biological process rhythmic behavior regulation of circadian sleep/wake cycle circadian rhythm regulation of circadian rhythm regulation of behavior behavior circadian behavior regulation of multicellular organismal process regulation of circadian sleep/wake cycle, sleep circadian sleep/wake cycle process serotonin metabolic process serotonin catabolic process primary amino compound metabolic process ammonium ion metabolic process indole-containing compound catabolic process primary amino compound catabolic process catecholamine catabolic process catechol-containing compound catabolic process dopamine metabolic process dopamine catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000182	GNAT domain	Domain
A	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.