5I9J

Structure of the cholesterol and lutein-binding domain of human STARD3 at 1.74A

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d5i9ja_	Alpha and beta proteins (a+b)	TBP-like	Bet v1-like	STAR domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bet v1-like	8036380	3000738	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	START	e5i9jA1	A: a+b two layers	X: TBP-like	H: Bet v1-like (From Topology)	T: Bet v1-like	F: START	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.530.20	Alpha Beta	2-Layer Sandwich	Alpha-D-Glucose-1,6-Bisphosphate	Chain A, domain 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01852	START domain (START)	START domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	StAR-related lipid transfer protein 3	sterol binding binding organic cyclic compound binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity cholesterol transfer activity identical protein binding sterol binding binding organic cyclic compound binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity cholesterol transfer activity identical protein binding protein binding protein homodimerization activity protein dimerization activity	vesicle localization establishment of organelle localization cellular localization transport establishment of vesicle localization vesicle tethering to endoplasmic reticulum establishment of localization vesicle targeting vesicle-mediated transport cellular component organization localization organelle localization establishment of localization in cell cellular process vesicle localization establishment of organelle localization cellular localization transport establishment of vesicle localization vesicle tethering to endoplasmic reticulum establishment of localization vesicle targeting vesicle-mediated transport cellular component organization localization organelle localization establishment of localization in cell cellular process cellular component organization or biogenesis vesicle tethering macromolecule localization lipid localization cholesterol transport lipid transport sterol transport organic hydroxy compound transport primary metabolic process metabolic process lipid metabolic process secondary alcohol metabolic process organic hydroxy compound metabolic process sterol metabolic process steroid metabolic process cholesterol metabolic process alcohol metabolic process small molecule metabolic process mitochondrial transport cellular biosynthetic process lipid biosynthetic process C21-steroid hormone metabolic process cellular ketone metabolic process progesterone metabolic process regulation of biological quality steroid biosynthetic process hormone biosynthetic process steroid hormone biosynthetic process olefinic compound biosynthetic process small molecule biosynthetic process progesterone biosynthetic process regulation of hormone levels cellular metabolic process biological regulation C21-steroid hormone biosynthetic process hormone metabolic process biosynthetic process olefinic compound metabolic process ketone biosynthetic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle organelle membrane contact site endoplasmic reticulum-endosome membrane contact site cytosol endosome membrane endosome membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle organelle membrane contact site endoplasmic reticulum-endosome membrane contact site cytosol endosome membrane endosome membrane intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome vesicle organelle membrane nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000799	Steroidogenic acute regulatory protein-like	Family
A	IPR029867	StAR-related lipid transfer protein 3, C-terminal	Domain
A	IPR023393	START-like domain superfamily	Homologous Superfamily
A	IPR019498	MENTAL domain	Domain
A	IPR002913	START domain	Domain
A	IPR051869	StAR-related Lipid Transfer (STARD3)	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14849	prostate cancer bipolar disorder inflammatory bowel disease rheumatoid arthritis cocaine use systemic lupus erythematosus Crohn disease ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.