Annotations: 5IL2

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Mettl3/Mettl14-like	8046758	4005285	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8090782	3000118	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8090781	3000118	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MT-A70	e5il2A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: MT-A70	ECOD (1.6)
B	MT-A70	e5il2B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: MT-A70	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF05063	MT-A70 (MT-A70)	MT-A70	-	Family
B	PF05063	MT-A70 (MT-A70)	MT-A70	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	METTL3	cation binding binding ion binding S-adenosyl-L-methionine binding sulfur compound binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid transferase activity cation binding binding ion binding S-adenosyl-L-methionine binding sulfur compound binding small molecule binding protein heterodimerization activity protein binding protein dimerization activity RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity mRNA m(6)A methyltransferase activity mRNA methyltransferase activity RNA binding organic cyclic compound binding nucleic acid binding mRNA binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process hemopoiesis biological regulation cell development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process hemopoiesis biological regulation cell development regulation of cell differentiation regulation of hematopoietic stem cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation anatomical structure development hematopoietic stem cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation rhythmic process circadian rhythm multicellular organismal process head development forebrain generation of neurons forebrain development animal organ development brain development nervous system development forebrain radial glial cell differentiation generation of neurons neurogenesis multicellular organism development gliogenesis central nervous system development glial cell differentiation radial glial cell differentiation system development oogenesis cellular process involved in reproduction in multicellular organism female gamete generation germ cell development nucleobase-containing compound metabolic process RNA modification macromolecule modification mRNA modification RNA metabolic process metabolic process primary metabolic process macromolecule metabolic process mRNA metabolic process nucleic acid metabolic process regulation of type I interferon-mediated signaling pathway negative regulation of biological process response to cytokine regulation of signal transduction response to biotic stimulus cell communication interferon-mediated signaling pathway cellular response to type I interferon cellular response to cytokine stimulus regulation of immune system process signal transduction immune response response to other organism regulation of innate immune response negative regulation of immune response response to external stimulus regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of response to stimulus response to chemical defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response response to type I interferon regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus negative regulation of response to biotic stimulus negative regulation of signaling signaling negative regulation of cell communication cytokine-mediated signaling pathway regulation of response to stress negative regulation of cellular process innate immune response response to external biotic stimulus regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus defense response regulation of cytokine-mediated signaling pathway defense response to symbiont negative regulation of signal transduction response to peptide negative regulation of immune system process negative regulation of cytokine-mediated signaling pathway immune system process type I interferon-mediated signaling pathway regulation of cell communication negative regulation of type I interferon-mediated signaling pathway negative regulation of innate immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process translational initiation positive regulation of macromolecule metabolic process cap-independent translational initiation regulation of translational initiation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process regulation of gene expression biosynthetic process positive regulation of cytoplasmic translational initiation regulation of macromolecule biosynthetic process positive regulation of translational initiation regulation of cytoplasmic translation regulation of metabolic process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process regulation of cap-independent translational initiation positive regulation of cap-independent translational initiation positive regulation of biosynthetic process protein metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of macromolecule metabolic process translation gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process positive regulation of gene expression regulation of translation regulation of cytoplasmic translational initiation cytoplasmic translation cytoplasmic translational initiation positive regulation of cellular biosynthetic process macromolecule methylation methylation RNA methylation regulation of cell adhesion cell morphogenesis negative regulation of cell adhesion endothelial to hematopoietic transition anatomical structure morphogenesis cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion delamination regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation T cell activation T cell differentiation regulation of multicellular organismal process regulation of lymphocyte differentiation regulation of multicellular organismal development cell activation regulation of T cell activation regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation nucleobase-containing compound biosynthetic process mRNA processing RNA biosynthetic process nucleic acid biosynthetic process RNA processing regulation of meiotic cell cycle regulation of reproductive process meiotic cell cycle cell cycle regulation of cell cycle Notch signaling pathway negative regulation of Notch signaling pathway regulation of Notch signaling pathway maintenance of cell number stem cell population maintenance negative regulation of cellular metabolic process cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process heterochromatin formation sex-chromosome dosage compensation epigenetic regulation of gene expression negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process dosage compensation by inactivation of X chromosome negative regulation of gene expression, epigenetic response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV RNA splicing RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulatory ncRNA processing regulatory ncRNA-mediated gene silencing primary miRNA processing miRNA processing regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA catabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process nucleobase-containing compound catabolic process positive regulation of RNA metabolic process nucleic acid catabolic process catabolic process mRNA destabilization macromolecule catabolic process regulation of mRNA catabolic process RNA destabilization regulation of catabolic process positive regulation of catabolic process regulation of mRNA stability positive regulation of mRNA catabolic process regulation of RNA stability regulation of mRNA metabolic process	protein-containing complex intracellular anatomical structure catalytic complex RNA N6-methyladenosine methyltransferase complex methyltransferase complex transferase complex cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body protein-containing complex intracellular anatomical structure catalytic complex RNA N6-methyladenosine methyltransferase complex methyltransferase complex transferase complex cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol oxidoreductase complex Golgi apparatus endomembrane system
B	METTL14	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity mRNA m(6)A methyltransferase activity RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding RNA methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity mRNA m(6)A methyltransferase activity mRNA methyltransferase activity	regulation of cellular process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of cellular process cellular biosynthetic process positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process protein metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process developmental process negative regulation of hematopoietic progenitor cell differentiation regulation of developmental process cellular developmental process negative regulation of developmental process hemopoiesis negative regulation of biological process cell development regulation of cell differentiation cell differentiation negative regulation of cellular process anatomical structure development negative regulation of cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation multicellular organismal process nervous system development neurogenesis multicellular organism development gliogenesis system development spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation head development forebrain generation of neurons forebrain development animal organ development brain development forebrain radial glial cell differentiation generation of neurons central nervous system development glial cell differentiation radial glial cell differentiation maintenance of cell number stem cell population maintenance catabolic process RNA metabolic process negative regulation of cellular metabolic process macromolecule catabolic process nucleobase-containing compound metabolic process RNA catabolic process negative regulation of macromolecule metabolic process mRNA catabolic process negative regulation of metabolic process mRNA metabolic process negative regulation of cellular biosynthetic process nucleic acid metabolic process nucleobase-containing compound catabolic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process neuron differentiation regulation of neuron differentiation RNA splicing nucleobase-containing compound biosynthetic process mRNA processing RNA biosynthetic process nucleic acid biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing RNA modification macromolecule modification mRNA modification macromolecule methylation methylation RNA methylation regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process positive regulation of RNA metabolic process mRNA destabilization regulation of mRNA catabolic process RNA destabilization regulation of catabolic process positive regulation of catabolic process regulation of mRNA stability positive regulation of mRNA catabolic process regulation of RNA stability regulation of mRNA metabolic process negative regulation of nucleobase-containing compound metabolic process mRNA stabilization negative regulation of RNA metabolic process negative regulation of mRNA metabolic process negative regulation of catabolic process negative regulation of mRNA catabolic process negative regulation of RNA catabolic process RNA stabilization	protein-containing complex intracellular anatomical structure catalytic complex RNA N6-methyladenosine methyltransferase complex methyltransferase complex transferase complex cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm protein-containing complex intracellular anatomical structure catalytic complex RNA N6-methyladenosine methyltransferase complex methyltransferase complex transferase complex cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A	IPR007757	MT-A70-like	Family
A	IPR025848	N6-adenosine-methyltransferase MT-A70-like	Family
B	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
B	IPR045123	N6-adenosine-methyltransferase non-catalytic subunit METTL14-like	Family
B	IPR007757	MT-A70-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q86U44	astrocytic tumor lymphoplasmacytic lymphoma medulloblastoma ovarian cancer Pick disease psoriasis atypical teratoid rhabdoid tumor malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor dermatomyositis malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia astrocytic tumor lymphoplasmacytic lymphoma medulloblastoma ovarian cancer Pick disease psoriasis atypical teratoid rhabdoid tumor malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor dermatomyositis malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia progressive supranuclear palsy
B	Pharos: Q9HCE5	cystic fibrosis osteosarcoma sinusitis juvenile dermatomyositis ovarian cancer medulloblastoma Pick disease

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
B	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.