Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad5imsa2 Alpha and beta proteins (a/b) DHS-like NAD/FAD-binding domain DHS-like NAD/FAD-binding domain Pyruvate oxidase and decarboxylase, middle domain Acetohydroxyacid synthase catalytic subunit Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ], SCOPe (2.08)
Ad5imsa1 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) Pyruvate oxidase and decarboxylase Pyr module Acetohydroxyacid synthase catalytic subunit Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ], SCOPe (2.08)
Ad5imsa3 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) Pyruvate oxidase and decarboxylase PP module Acetohydroxyacid synthase catalytic subunit Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ], SCOPe (2.08)
Bd5imsb2 Alpha and beta proteins (a/b) DHS-like NAD/FAD-binding domain DHS-like NAD/FAD-binding domain Pyruvate oxidase and decarboxylase, middle domain Acetohydroxyacid synthase catalytic subunit Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ], SCOPe (2.08)
Bd5imsb1 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) Pyruvate oxidase and decarboxylase Pyr module Acetohydroxyacid synthase catalytic subunit Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ], SCOPe (2.08)
Bd5imsb3 Alpha and beta proteins (a/b) Thiamin diphosphate-binding fold (THDP-binding) Thiamin diphosphate-binding fold (THDP-binding) Pyruvate oxidase and decarboxylase PP module Acetohydroxyacid synthase catalytic subunit Baker's yeast (Saccharomyces cerevisiae S288C ) [TaxId: 559292 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042434 3001790 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDHS-like NAD/FAD-binding domain 8042432 3001728 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThiamin diphosphate-binding fold (THDP-binding) 8042435 3001790 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ATPP_enzyme_Me5imsA3 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
ATPP_enzyme_Ce5imsA1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
ATPP_enzyme_Ne5imsA2 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)
BTPP_enzyme_Me5imsB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: DHS-like NAD/FAD-binding domainF: TPP_enzyme_MECOD (1.6)
BTPP_enzyme_Ce5imsB1 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_CECOD (1.6)
BTPP_enzyme_Ne5imsB3 A: a/b three-layered sandwichesX: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)H: Thiamin diphosphate-binding fold (THDP-binding) (From Topology)T: Thiamin diphosphate-binding fold (THDP-binding)F: TPP_enzyme_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00205Thiamine pyrophosphate enzyme, central domain (TPP_enzyme_M)Thiamine pyrophosphate enzyme, central domainThe central domain of TPP enzymes contains a 2-fold Rossman fold.Domain
A, B
PF02775Thiamine pyrophosphate enzyme, C-terminal TPP binding domain (TPP_enzyme_C)Thiamine pyrophosphate enzyme, C-terminal TPP binding domain- Domain
A, B
PF02776Thiamine pyrophosphate enzyme, N-terminal TPP binding domain (TPP_enzyme_N)Thiamine pyrophosphate enzyme, N-terminal TPP binding domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Acetolactate synthase catalytic subunit, mitochondrial