Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyE set domains 8073018 3000070 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyE set domains 8073018 3000070 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyE set domains 8073018 3000070 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFlavi_glycop_Ce5ireA1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Flavi_glycop_CECOD (1.6)
AFlavi_glycoprote5ireA2 A: beta complex topologyX: Viral glycoprotein, central and dimerisation domains-likeH: Viral glycoprotein, central and dimerisation domains (From Topology)T: Viral glycoprotein, central and dimerisation domainsF: Flavi_glycoprotECOD (1.6)
Aflavi_E_steme5ireA3 A: alpha arraysX: Transmembrane domain of envelope protein E (From Topology)H: Transmembrane domain of envelope protein E (From Topology)T: Transmembrane domain of envelope protein EF: flavi_E_stemECOD (1.6)
CFlavi_glycop_Ce5ireC1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Flavi_glycop_CECOD (1.6)
CFlavi_glycoprote5ireC2 A: beta complex topologyX: Viral glycoprotein, central and dimerisation domains-likeH: Viral glycoprotein, central and dimerisation domains (From Topology)T: Viral glycoprotein, central and dimerisation domainsF: Flavi_glycoprotECOD (1.6)
Cflavi_E_steme5ireC3 A: alpha arraysX: Transmembrane domain of envelope protein E (From Topology)H: Transmembrane domain of envelope protein E (From Topology)T: Transmembrane domain of envelope protein EF: flavi_E_stemECOD (1.6)
EFlavi_glycop_Ce5ireE1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: Flavi_glycop_CECOD (1.6)
EFlavi_glycoprote5ireE3 A: beta complex topologyX: Viral glycoprotein, central and dimerisation domains-likeH: Viral glycoprotein, central and dimerisation domains (From Topology)T: Viral glycoprotein, central and dimerisation domainsF: Flavi_glycoprotECOD (1.6)
Eflavi_E_steme5ireE2 A: alpha arraysX: Transmembrane domain of envelope protein E (From Topology)H: Transmembrane domain of envelope protein E (From Topology)T: Transmembrane domain of envelope protein EF: flavi_E_stemECOD (1.6)
BFlavi_Me5ireB1 A: extended segmentsX: Small envelope protein M (From Topology)H: Small envelope protein M (From Topology)T: Small envelope protein MF: Flavi_MECOD (1.6)
DFlavi_Me5ireD1 A: extended segmentsX: Small envelope protein M (From Topology)H: Small envelope protein M (From Topology)T: Small envelope protein MF: Flavi_MECOD (1.6)
FFlavi_Me5ireF1 A: extended segmentsX: Small envelope protein M (From Topology)H: Small envelope protein M (From Topology)T: Small envelope protein MF: Flavi_MECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.60.98.10 Mainly Beta Sandwich Tick-borne Encephalitis virus Glycoprotein domain 1CATH (4.3.0)
A3.30.67.10 Alpha Beta 2-Layer Sandwich Viral Envelope Glycoprotein domain 2CATH (4.3.0)
A3.30.387.10 Alpha Beta 2-Layer Sandwich Viral Envelope Glycoprotein domain 3CATH (4.3.0)
A2.60.40.350 Mainly Beta Sandwich Immunoglobulin-like CATH (4.3.0)
A1.20.1280.260 Mainly Alpha Up-down Bundle Monooxygenase CATH (4.3.0)
C2.60.98.10 Mainly Beta Sandwich Tick-borne Encephalitis virus Glycoprotein domain 1CATH (4.3.0)
C3.30.67.10 Alpha Beta 2-Layer Sandwich Viral Envelope Glycoprotein domain 2CATH (4.3.0)
C3.30.387.10 Alpha Beta 2-Layer Sandwich Viral Envelope Glycoprotein domain 3CATH (4.3.0)
C2.60.40.350 Mainly Beta Sandwich Immunoglobulin-like CATH (4.3.0)
C1.20.1280.260 Mainly Alpha Up-down Bundle Monooxygenase CATH (4.3.0)
E2.60.98.10 Mainly Beta Sandwich Tick-borne Encephalitis virus Glycoprotein domain 1CATH (4.3.0)
E3.30.67.10 Alpha Beta 2-Layer Sandwich Viral Envelope Glycoprotein domain 2CATH (4.3.0)
E3.30.387.10 Alpha Beta 2-Layer Sandwich Viral Envelope Glycoprotein domain 3CATH (4.3.0)
E2.60.40.350 Mainly Beta Sandwich Immunoglobulin-like CATH (4.3.0)
E1.20.1280.260 Mainly Alpha Up-down Bundle Monooxygenase CATH (4.3.0)
B1.10.8.970 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
D1.10.8.970 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)
F1.10.8.970 Mainly Alpha Orthogonal Bundle Helicase, Ruva Protein domain 3CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, C, E
PF00869Flavivirus glycoprotein, central and dimerisation domains (Flavi_glycoprot)Flavivirus glycoprotein, central and dimerisation domains- Domain
A, C, E
PF21659Flavivirus envelope glycoprotein E, stem/anchor domain (Flavi_E_stem)Flavivirus envelope glycoprotein E, stem/anchor domainThis entry represents the stem/anchor domain found at the C-terminal of envelope glycoprotein E from Flavivirus. This domain comprises a stem region followed by two transmembrane anchor domains [1-5].Domain
A, C, E
PF02832Flavivirus glycoprotein, immunoglobulin-like domain (Flavi_glycop_C)Flavivirus glycoprotein, immunoglobulin-like domain- Domain
B, D, F
PF01004Flavivirus envelope glycoprotein M (Flavi_M)Flavivirus envelope glycoprotein M- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E
E protein
B, D, F
M protein

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C, E
IPR000208RNA-directed RNA polymerase, fingers/palm subdomains, flavivirusDomain
A, C, E
IPR014756Immunoglobulin E-setHomologous Superfamily
A, C, E
IPR001122Capsid protein C, flavivirusDomain
A, C, E
IPR027287Glycoprotein E, immunoglobulin-like domain, flavivirusDomain
A, C, E
IPR014412Genome polyprotein, FlavivirusFamily
A, C, E
IPR036253Flavivirus glycoprotein, central and dimerisation domain superfamilyHomologous Superfamily
A, C, E
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
A, C, E
IPR026490mRNA cap 0/1 methyltransferaseDomain
A, C, E
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, C, E
IPR001650Helicase, C-terminal domain-likeDomain
A, C, E
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
A, C, E
IPR013755Flaviviral glycoprotein E, central domain, subdomain 1Homologous Superfamily
A, C, E
IPR000752Flavivirus non-structural protein NS2ADomain
A, C, E
IPR047530RNA-dependent RNA polymerase, flavivirusDomain
A, C, E
IPR049486Flavivridae NS3 helicase, C-terminal helical domainDomain
A, C, E
IPR046811RNA-directed RNA polymerase, thumb subdomain, flavivirusDomain
A, C, E
IPR038055Flaviviral glycoprotein E, dimerisation domainHomologous Superfamily
A, C, E
IPR002877Ribosomal RNA methyltransferase, FtsJ domainDomain
A, C, E
IPR038302Envelope glycoprotein M superfamily, flavivirusHomologous Superfamily
A, C, E
IPR000069Envelope glycoprotein M, flavivirusDomain
A, C, E
IPR011492Non-structural protein NS3-like, DEAD box helicase, flavivirusDomain
A, C, E
IPR038345Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamilyHomologous Superfamily
A, C, E
IPR038688Flavivirus polyprotein propeptide superfamilyHomologous Superfamily
A, C, E
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
A, C, E
IPR026470Flavivirus envelope glycoprotein E, Stem/Anchor domainDomain
A, C, E
IPR011998Envelope glycoprotein E, central and dimerisation domain, flavivirusDomain
A, C, E
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
A, C, E
IPR037172Flavivirus capsid protein C superfamilyHomologous Superfamily
A, C, E
IPR000404Flavivirus non-structural protein NS4ADomain
A, C, E
IPR000487Non-structural protein NS2B, flavivirusDomain
A, C, E
IPR001528Flavivirus non-structural protein NS4BDomain
A, C, E
IPR001157Non-structural protein NS1, flavivirusDomain
A, C, E
IPR013756Flaviviral glycoprotein E, central domain, subdomain 2Homologous Superfamily
A, C, E
IPR001850Non-structural protein NS3, peptidase S7, flavivirusDomain
A, C, E
IPR000336Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamilyHomologous Superfamily
A, C, E
IPR002535Flavivirus polyprotein propeptideDomain
A, C, E
IPR007094RNA-directed RNA polymerase, catalytic domainDomain
B, D, F
IPR000208RNA-directed RNA polymerase, fingers/palm subdomains, flavivirusDomain
B, D, F
IPR014756Immunoglobulin E-setHomologous Superfamily
B, D, F
IPR001122Capsid protein C, flavivirusDomain
B, D, F
IPR027287Glycoprotein E, immunoglobulin-like domain, flavivirusDomain
B, D, F
IPR014412Genome polyprotein, FlavivirusFamily
B, D, F
IPR036253Flavivirus glycoprotein, central and dimerisation domain superfamilyHomologous Superfamily
B, D, F
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
B, D, F
IPR026490mRNA cap 0/1 methyltransferaseDomain
B, D, F
IPR009003Peptidase S1, PA clanHomologous Superfamily
B, D, F
IPR001650Helicase, C-terminal domain-likeDomain
B, D, F
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain
B, D, F
IPR013755Flaviviral glycoprotein E, central domain, subdomain 1Homologous Superfamily
B, D, F
IPR000752Flavivirus non-structural protein NS2ADomain
B, D, F
IPR047530RNA-dependent RNA polymerase, flavivirusDomain
B, D, F
IPR049486Flavivridae NS3 helicase, C-terminal helical domainDomain
B, D, F
IPR046811RNA-directed RNA polymerase, thumb subdomain, flavivirusDomain
B, D, F
IPR038055Flaviviral glycoprotein E, dimerisation domainHomologous Superfamily
B, D, F
IPR002877Ribosomal RNA methyltransferase, FtsJ domainDomain
B, D, F
IPR038302Envelope glycoprotein M superfamily, flavivirusHomologous Superfamily
B, D, F
IPR000069Envelope glycoprotein M, flavivirusDomain
B, D, F
IPR011492Non-structural protein NS3-like, DEAD box helicase, flavivirusDomain
B, D, F
IPR038345Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamilyHomologous Superfamily
B, D, F
IPR038688Flavivirus polyprotein propeptide superfamilyHomologous Superfamily
B, D, F
IPR029063S-adenosyl-L-methionine-dependent methyltransferase superfamilyHomologous Superfamily
B, D, F
IPR026470Flavivirus envelope glycoprotein E, Stem/Anchor domainDomain
B, D, F
IPR011998Envelope glycoprotein E, central and dimerisation domain, flavivirusDomain
B, D, F
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
B, D, F
IPR037172Flavivirus capsid protein C superfamilyHomologous Superfamily
B, D, F
IPR000404Flavivirus non-structural protein NS4ADomain
B, D, F
IPR000487Non-structural protein NS2B, flavivirusDomain
B, D, F
IPR001528Flavivirus non-structural protein NS4BDomain
B, D, F
IPR001157Non-structural protein NS1, flavivirusDomain
B, D, F
IPR013756Flaviviral glycoprotein E, central domain, subdomain 2Homologous Superfamily
B, D, F
IPR001850Non-structural protein NS3, peptidase S7, flavivirusDomain
B, D, F
IPR000336Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamilyHomologous Superfamily
B, D, F
IPR002535Flavivirus polyprotein propeptideDomain
B, D, F
IPR007094RNA-directed RNA polymerase, catalytic domainDomain

Membrane Protein Annotation: OPM OPM Database Homepage

ChainsExternal LinkTypeClassSuperfamilyFamily
A, B, C, D, E
OPMTransmembraneBitopic proteinsViral membrane fusion glycoproteinFlavivirus glycoprotein