5KTW

CREBBP bromodomain in complex with Cpd 44 (3-((5-acetyl-1-(cyclopropylmethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-isopropylbenzamide)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d5ktwb1	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	CREB-binding protein, CBP	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d5ktwb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5ktwa1	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	CREB-binding protein, CBP	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d5ktwa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5ktwc1	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	CREB-binding protein, CBP	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d5ktwc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Bromodomain	8040939	3001843	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Bromodomain	8040939	3001843	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Bromodomain	8040939	3001843	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Bromodomain	e5ktwB1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
A	Bromodomain	e5ktwA1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
C	Bromodomain	e5ktwC1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
A	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
C	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00439	Bromodomain (Bromodomain)	Bromodomain	Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	CREB-binding protein	transcription factor binding protein binding binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity catalytic activity, acting on a protein N-acetyltransferase activity histone H3 acetyltransferase activity transcription factor binding protein binding binding bHLH transcription factor binding DNA-binding transcription factor binding MRF binding acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity catalytic activity, acting on a protein N-acetyltransferase activity histone H3 acetyltransferase activity peptide N-acetyltransferase activity histone H3K27 acetyltransferase activity histone acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity N-acyltransferase activity p53 binding RNA polymerase II-specific DNA-binding transcription factor binding chromatin binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding histone H3K18 acetyltransferase activity transcription corepressor activity peptide lactyltransferase (CoA-dependent) activity transcription coregulator binding transcription coactivator binding chromatin DNA binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	protein destabilization regulation of protein stability biological regulation regulation of biological quality cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular process regulation of DNA recombination regulation of cellular process regulation of double-strand break repair regulation of cellular response to stress positive regulation of biological process protein destabilization regulation of protein stability biological regulation regulation of biological quality cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus cellular process regulation of DNA recombination regulation of cellular process regulation of double-strand break repair regulation of cellular response to stress positive regulation of biological process positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination positive regulation of cellular process DNA repair positive regulation of DNA recombination double-strand break repair regulation of biological process positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular response to heat regulation of cellular response to heat response to heat response to temperature stimulus cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular component organization or biogenesis protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization signaling canonical NF-kappaB signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling smoothened signaling pathway regulation of smoothened signaling pathway peptidyl-lysine acetylation N-terminal peptidyl-lysine acetylation peptidyl-lysine modification protein acylation protein maturation protein acetylation N-terminal protein amino acid modification macromolecule modification peptidyl-amino acid modification N-terminal protein amino acid acetylation protein metabolic process protein modification process positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus response to lectin defense response to other organism cellular response to lectin positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway innate immune response response to external biotic stimulus positive regulation of innate immune response defense response defense response to symbiont stimulatory C-type lectin receptor signaling pathway immune system process rhythmic process response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV homeostatic process negative regulation of transcription by RNA polymerase I transcription by RNA polymerase I regulation of transcription by RNA polymerase I developmental process multicellular organismal process limb development appendage development embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development multicellular organism development anatomical structure morphogenesis appendage morphogenesis anatomical structure development embryonic digit morphogenesis limb morphogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic complex transferase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic complex transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen nuclear body

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
A, B, C	IPR018359	Bromodomain, conserved site	Conserved Site
A, B, C	IPR036529	Coactivator CBP, KIX domain superfamily	Homologous Superfamily
A, B, C	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
A, B, C	IPR000197	Zinc finger, TAZ-type	Domain
A, B, C	IPR000433	Zinc finger, ZZ-type	Domain
A, B, C	IPR003101	Coactivator CBP, KIX domain	Domain
A, B, C	IPR013178	Histone acetyltransferase Rtt109/CBP	Family
A, B, C	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B, C	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A, B, C	IPR010303	CREB-binding protein/p300, atypical RING domain	Domain
A, B, C	IPR001487	Bromodomain	Domain
A, B, C	IPR035898	TAZ domain superfamily	Homologous Superfamily
A, B, C	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Homologous Superfamily
A, B, C	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking	Domain
A, B, C	IPR038547	CBP/p300, atypical RING domain superfamily	Homologous Superfamily
A, B, C	IPR031162	CBP/p300-type histone acetyltransferase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C	Pharos: Q92793	Rubinstein-Taybi syndrome transitional cell carcinoma urinary bladder cancer esophageal squamous cell carcinoma follicular lymphoma Rubinstein-Taybi syndrome due to CREBBP mutations adenoid cystic carcinoma Sezary syndrome small cell lung carcinoma prostate cancer salivary gland adenoid cystic carcinoma squamous cell carcinoma Rubinstein-Taybi syndrome due to 16p13.3 microdeletion amyotrophic lateral sclerosis type 1 Lymphoma, Large-Cell, Follicular Rubinstein-Taybi syndrome transitional cell carcinoma urinary bladder cancer esophageal squamous cell carcinoma follicular lymphoma Rubinstein-Taybi syndrome due to CREBBP mutations adenoid cystic carcinoma Sezary syndrome small cell lung carcinoma prostate cancer salivary gland adenoid cystic carcinoma squamous cell carcinoma Rubinstein-Taybi syndrome due to 16p13.3 microdeletion amyotrophic lateral sclerosis type 1 Lymphoma, Large-Cell, Follicular non-Hodgkin lymphoma ovarian cancer acute myeloid leukemia cancer endogenous depression intellectual disability osteogenesis imperfecta plasma cell myeloma acute myeloid leukemia with t(8;16)(p11;p13) translocation small cell carcinoma astrocytic tumor cleft lip lung adenocarcinoma osteosarcoma schizophrenia bipolar disorder subependymal giant cell astrocytoma diffuse large B-cell lymphoma urinary bladder neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.