Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Bd5ky0b_ Small proteins Knottins (small inhibitors, toxins, lectins) EGF/Laminin automated matches automated matches Mouse (Mus musculus ) [TaxId: 10090 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AO-FucT_Ce5ky0A2 A: a/b three-layered sandwichesX: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)T: UDP-Glycosyltransferase/glycogen phosphorylaseF: O-FucT_CECOD (1.6)
AO-FucT_Ne5ky0A1 A: a/b three-layered sandwichesX: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)H: UDP-Glycosyltransferase/glycogen phosphorylase (From Topology)T: UDP-Glycosyltransferase/glycogen phosphorylaseF: O-FucT_NECOD (1.6)
BhEGF_2e5ky0B1 A: few secondary structure elementsX: EGF-likeH: EGF-relatedT: EGF/LamininF: hEGF_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.11340 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)
A3.40.50.11350 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF10250GDP-fucose protein O-fucosyltransferase (O-FucT)GDP-fucose protein O-fucosyltransferase- Family
PF12661Human growth factor-like EGF (hEGF)Human growth factor-like EGFhEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteristic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selec ...hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteristic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
GDP-fucose protein O-fucosyltransferase 1
Neurogenic locus notch homolog protein 1