5LA9

HIF prolyl hydroxylase 2 (PHD2-R281C/V314C) cross-linked to HIF-1alpha NODD-L397C/D412C and N-oxalylglycine (NOG) (complex-2)

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	2OG-FeII_Oxy_3	e5la9A1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: 2OG-FeII_Oxy_3	ECOD (1.6)
B	2OG-FeII_Oxy_3	e5la9B1	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: 2OG-FeII_Oxy_3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.620	Mainly Beta	Sandwich	Jelly Rolls	q2cbj1_9rhob like domain	CATH (4.3.0)
B	2.60.120.620	Mainly Beta	Sandwich	Jelly Rolls	q2cbj1_9rhob like domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13640	2OG-Fe(II) oxygenase superfamily (2OG-FeII_Oxy_3)	2OG-Fe(II) oxygenase superfamily	This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Egl nine homolog 1	cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding peptidyl-proline 4-dioxygenase activity oxidoreductase activity catalytic activity, acting on a protein oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-proline dioxygenase activity catalytic activity cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding peptidyl-proline 4-dioxygenase activity oxidoreductase activity catalytic activity, acting on a protein oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen peptidyl-proline dioxygenase activity catalytic activity 2-oxoglutarate-dependent dioxygenase activity dioxygenase activity organic acid binding carbohydrate binding vitamin binding organic cyclic compound binding anion binding monosaccharide binding carboxylic acid binding heterocyclic compound binding L-ascorbic acid binding hypoxia-inducible factor-proline dioxygenase activity protein binding enzyme binding	intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis developmental process multicellular organismal process regulation of multicellular organismal development regulation of biological process regulation of developmental process blood vessel morphogenesis tube development biological regulation angiogenesis vasculature development regulation of vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis regulation of angiogenesis anatomical structure development anatomical structure formation involved in morphogenesis regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development heart development cardiac chamber morphogenesis animal organ development heart morphogenesis ventricular septum development cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development regulation of cellular process cellular biosynthetic process negative regulation of DNA-binding transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process negative regulation of molecular function primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process cardiac muscle tissue development tissue development muscle tissue morphogenesis striated muscle tissue development muscle structure development tissue morphogenesis cardiac muscle tissue morphogenesis muscle organ development muscle tissue development muscle organ morphogenesis placenta development chordate embryonic development labyrinthine layer development embryo development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching embryonic organ development response to decreased oxygen levels cellular response to stimulus response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to chemical response to oxygen levels response to abiotic stimulus regulation protein catabolic process at synapse catabolic process regulation of catabolic process regulation protein catabolic process at postsynapse negative regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity negative regulation of cyclic-nucleotide phosphodiesterase activity negative regulation of catalytic activity regulation of cyclic-nucleotide phosphodiesterase activity heart trabecula formation heart trabecula morphogenesis trabecula formation trabecula morphogenesis intracellular oxygen homeostasis positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process transcription by RNA polymerase II positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of cellular component organization regulation of modification of synaptic structure cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity regulation of modification of postsynaptic structure synapse organization cellular component organization or biogenesis regulation of biological quality modification of synaptic structure modification of postsynaptic structure response to nitric oxide response to oxygen-containing compound response to nitrogen compound	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle synapse cell junction glutamatergic synapse postsynaptic density postsynapse neuron to neuron synapse intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle synapse cell junction glutamatergic synapse postsynaptic density postsynapse neuron to neuron synapse postsynaptic specialization asymmetric synapse nucleus
C, D	Hypoxia-inducible factor 1-alpha	histone deacetylase binding protein binding binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein domain specific binding kinase binding protein kinase binding histone deacetylase binding protein binding binding enzyme binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity protein domain specific binding kinase binding protein kinase binding transcription factor binding transcription coregulator binding transcription coactivator binding E-box binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding DNA-binding transcription repressor activity p53 binding Hsp90 protein binding heat shock protein binding molecular function activator activity molecular function regulator activity transcription regulator activator activity protein heterodimerization activity protein dimerization activity	response to stimulus response to activity response to muscle activity multicellular organismal process embryonic epithelial tube formation chordate embryonic development neural fold formation tube formation embryo development multicellular organism development epithelial tube formation primary neural tube formation tube morphogenesis neural fold elevation formation response to stimulus response to activity response to muscle activity multicellular organismal process embryonic epithelial tube formation chordate embryonic development neural fold formation tube formation embryo development multicellular organism development epithelial tube formation primary neural tube formation tube morphogenesis neural fold elevation formation embryo development ending in birth or egg hatching anatomical structure development epithelial tube morphogenesis system development developmental process morphogenesis of an epithelial fold morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development tissue morphogenesis anatomical structure morphogenesis neural tube formation anatomical structure formation involved in morphogenesis ossification bone mineralization animal organ development biomineral tissue development cellular developmental process cell development epithelial cell differentiation intestinal epithelial cell maturation columnar/cuboidal epithelial cell development cell differentiation cell maturation digestive system development intestinal epithelial cell differentiation intestinal epithelial cell development developmental maturation digestive tract development epithelial cell development anatomical structure maturation cellular process columnar/cuboidal epithelial cell differentiation epithelial cell maturation columnar/cuboidal epithelial cell maturation ribonucleotide catabolic process pyridine nucleotide catabolic process regulation of cellular process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of primary metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process pyruvate metabolic process regulation of biological process cellular metabolic process purine nucleoside diphosphate metabolic process primary metabolic process regulation of cellular metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process metabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process regulation of metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process biological regulation ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process response to metal ion response to iron ion response to chemical positive regulation of macromolecule biosynthetic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of miRNA transcription cellular response to stimulus response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress cellular response to oxidative stress cellular response to chemical stress hemopoiesis embryonic hemopoiesis embryonic organ development mammary gland epithelial cell differentiation mammary gland development gland development epithelial cell differentiation involved in mammary gland alveolus development mammary gland lobule development mammary gland epithelium development mammary gland alveolus development regulation of cytokine production cytokine production regulation of multicellular organismal process regulation of chemokine production positive regulation of gene expression chemokine production positive regulation of chemokine production positive regulation of multicellular organismal process positive regulation of cytokine production negative regulation of metabolic process reactive oxygen species metabolic process negative regulation of biological process negative regulation of cellular metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of cellular process regulation of reactive oxygen species metabolic process camera-type eye morphogenesis sensory organ development eye development visual system development eye morphogenesis sensory organ morphogenesis camera-type eye development iris morphogenesis animal organ morphogenesis sensory system development glandular epithelial cell development glandular epithelial cell maturation glandular epithelial cell differentiation digestive tract morphogenesis regulation of body fluid levels secretion transport establishment of localization body fluid secretion localization lactation regulation of biological quality negative regulation of mesenchymal cell apoptotic process mesenchymal cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of mesenchymal cell apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death response to decreased oxygen levels cellular response to oxygen levels signaling cellular response to hypoxia cellular response to decreased oxygen levels intracellular signal transduction cell communication response to hypoxia hypoxia-inducible factor-1alpha signaling pathway response to oxygen levels response to abiotic stimulus signal transduction connective tissue development skeletal system development chondrocyte differentiation cartilage development protein metabolic process glycoprotein metabolic process elastin metabolic process response to oxygen-containing compound response to reactive oxygen species response to peptide cellular response to interleukin-1 response to cytokine cellular response to cytokine stimulus response to interleukin-1 establishment of organelle localization cellular localization organelle transport along microtubule establishment of mitochondrion localization intracellular transport axonal transport mitochondrion localization establishment of mitochondrion localization, microtubule-mediated axo-dendritic transport mitochondrion transport along microtubule organelle localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement microtubule-based process axonal transport of mitochondrion retina vasculature development in camera-type eye retina development in camera-type eye vasculature development circulatory system development cellular catabolic process positive regulation of ATP metabolic process positive regulation of carbohydrate metabolic process positive regulation of purine nucleotide catabolic process positive regulation of glycolytic process positive regulation of catabolic process positive regulation of phosphate metabolic process positive regulation of nucleotide catabolic process positive regulation of phosphorus metabolic process positive regulation of nucleotide metabolic process positive regulation of purine nucleotide metabolic process regulation of cellular catabolic process positive regulation of cellular catabolic process positive regulation of small molecule metabolic process positive regulation of cell communication positive regulation of signal transduction regulation of chemokine-mediated signaling pathway response to chemokine regulation of signal transduction positive regulation of response to cytokine stimulus cytokine-mediated signaling pathway cellular response to chemokine chemokine-mediated signaling pathway positive regulation of response to stimulus positive regulation of chemokine-mediated signaling pathway regulation of G protein-coupled receptor signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of cytokine-mediated signaling pathway positive regulation of G protein-coupled receptor signaling pathway regulation of response to cytokine stimulus regulation of response to stimulus regulation of cell communication G protein-coupled receptor signaling pathway positive regulation of cytokine-mediated signaling pathway positive regulation of signaling placenta development in utero embryonic development embryonic placenta development regulation of protein modification process regulation of post-translational protein modification regulation of protein metabolic process regulation of protein neddylation macromolecule modification regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification protein neddylation protein modification by small protein conjugation protein modification by small protein conjugation or removal negative regulation of miRNA transcription negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process negative regulation of miRNA metabolic process positive regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of blood vessel endothelial cell migration regulation of locomotion positive regulation of endothelial cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration cell migration cell motility locomotion neuron apoptotic process collagen metabolic process regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response defense response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response inflammatory response negative regulation of gene expression cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation dopaminergic neuron differentiation generation of neurons neurogenesis neuron differentiation heart development heart morphogenesis outflow tract morphogenesis positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration epithelial cell migration regulation of epithelial cell migration epithelium migration intracellular iron ion homeostasis inorganic ion homeostasis cellular homeostasis chemical homeostasis homeostatic process intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis neuroblast proliferation neural precursor cell proliferation glucose homeostasis carbohydrate homeostasis intracellular glucose homeostasis regulation of catalytic activity positive regulation of catalytic activity regulation of oxidoreductase activity positive regulation of oxidoreductase activity positive regulation of nitric-oxide synthase activity regulation of molecular function positive regulation of molecular function regulation of monooxygenase activity positive regulation of monooxygenase activity regulation of nitric-oxide synthase activity cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway regulation of vascular endothelial growth factor receptor signaling pathway cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus vascular endothelial growth factor receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway response to growth factor cardiac chamber morphogenesis cardiac ventricle morphogenesis cardiac chamber development cardiac ventricle development regulation of hormone biosynthetic process regulation of hormone metabolic process hormone biosynthetic process positive regulation of hormone metabolic process regulation of hormone levels hormone metabolic process positive regulation of hormone biosynthetic process intracellular oxygen homeostasis positive regulation of signaling receptor activity regulation of signaling receptor activity head development forebrain development brain development pallium development cerebral cortex development central nervous system development telencephalon development negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of cell communication negative regulation of TOR signaling regulation of intracellular signal transduction TOR signaling regulation of TOR signaling negative regulation of response to stimulus negative regulation of signal transduction mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition regulation of developmental process regulation of cell differentiation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation regulation of immune system process myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells regulation of transforming growth factor beta production regulation of transforming growth factor beta2 production transforming growth factor beta production transforming growth factor beta2 production intrinsic apoptotic signaling pathway in response to oxidative stress regulation of oxidative stress-induced intrinsic apoptotic signaling pathway negative regulation of neuron apoptotic process regulation of intrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway neuron intrinsic apoptotic signaling pathway in response to oxidative stress apoptotic signaling pathway negative regulation of intrinsic apoptotic signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway regulation of neuron apoptotic process regulation of apoptotic signaling pathway regulation of growth negative regulation of growth growth aerobic respiration cellular respiration energy derivation by oxidation of organic compounds regulation of cellular respiration regulation of aerobic respiration transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II pattern specification process embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry determination of left/right symmetry specification of symmetry embryonic organ morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation muscle cell cellular homeostasis regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production blood vessel morphogenesis angiogenesis blood vessel development wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response inflammatory response to wounding tissue remodeling connective tissue replacement response to wounding organic hydroxy compound metabolic process lactate metabolic process stem cell development neural crest cell differentiation neural crest cell development mesenchymal cell migration stem cell differentiation neural crest cell migration response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation protein localization establishment of protein localization nitrogen compound transport cellular macromolecule localization establishment of protein localization to extracellular region protein secretion cellular response to oxygen-containing compound cellular response to carbohydrate stimulus response to glucose insulin secretion involved in cellular response to glucose stimulus hormone secretion protein localization to extracellular region peptide secretion secretion by cell response to monosaccharide response to carbohydrate amide transport signal release cellular response to hexose stimulus cellular response to monosaccharide stimulus cell-cell signaling export from cell cellular response to glucose stimulus peptide transport response to hexose protein transport peptide hormone secretion macromolecule localization hormone transport insulin secretion regulation of localization positive regulation of establishment of protein localization positive regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of insulin secretion regulation of peptide hormone secretion positive regulation of peptide hormone secretion regulation of protein secretion regulation of secretion positive regulation of protein localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion positive regulation of secretion by cell positive regulation of protein transport regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion positive regulation of peptide secretion regulation of transport regulation of peptide transport regulation of establishment of protein localization regulation of protein transport positive regulation of protein secretion positive regulation of transport regulation of cellular localization regulation of insulin secretion regulation of insulin secretion involved in cellular response to glucose stimulus hemoglobin biosynthetic process hemoglobin metabolic process regulation of vasculature development regulation of anatomical structure morphogenesis positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis B cell homeostasis leukocyte homeostasis B-1 B cell homeostasis lymphocyte homeostasis macroautophagy autophagy regulation of autophagy positive regulation of autophagy of mitochondrion mitophagy regulation of autophagy of mitochondrion positive regulation of macroautophagy process utilizing autophagic mechanism positive regulation of autophagy positive regulation of mitophagy regulation of mitophagy regulation of macroautophagy autophagy of mitochondrion negative regulation of thymocyte apoptotic process leukocyte apoptotic process lymphocyte apoptotic process thymocyte apoptotic process negative regulation of leukocyte apoptotic process regulation of T cell apoptotic process regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process negative regulation of T cell apoptotic process regulation of thymocyte apoptotic process T cell apoptotic process negative regulation of lymphocyte apoptotic process positive regulation of nervous system development regulation of neuroblast proliferation regulation of neurogenesis regulation of nervous system development positive regulation of neurogenesis regulation of neural precursor cell proliferation positive regulation of cell development positive regulation of neural precursor cell proliferation positive regulation of neuroblast proliferation cellular response to virus biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus negative regulation of biomineral tissue development regulation of biomineral tissue development regulation of bone mineralization negative regulation of bone mineralization negative regulation of developmental process negative regulation of ossification negative regulation of multicellular organismal process regulation of ossification	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection cilium motile cilium protein-containing complex euchromatin intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription regulator complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006620	Prolyl 4-hydroxylase, alpha subunit	Domain
A, B	IPR002893	Zinc finger, MYND-type	Domain
A, B	IPR044862	Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain	Domain
A, B	IPR051559	Hypoxia-inducible factor prolyl hydroxylases	Family
A, B	IPR005123	Oxoglutarate/iron-dependent dioxygenase domain	Domain
C, D	IPR013655	PAS fold-3	Domain
C, D	IPR001321	Hypoxia-inducible factor-1 alpha	Family
C, D	IPR035965	PAS domain superfamily	Homologous Superfamily
C, D	IPR014887	HIF-1 alpha, C-terminal transactivation domain	Domain
C, D	IPR000014	PAS domain	Domain
C, D	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain	Domain
C, D	IPR001610	PAC motif	Repeat
C, D	IPR036638	Helix-loop-helix DNA-binding domain superfamily	Homologous Superfamily
C, D	IPR021537	Hypoxia-inducible factor, alpha subunit-like	Domain
C, D	IPR013767	PAS fold	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9GZT9	erythrocytosis, familial, 3 familial polycythemia polycythemia ovarian cancer Refractory anemia (clinical) toxic encephalopathy acquired polycythemia vera facioscapulohumeral muscular dystrophy glioblastoma malignant glioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma adrenal medulla cancer atypical teratoid rhabdoid tumor large cell medulloblastoma erythrocytosis, familial, 3 familial polycythemia polycythemia ovarian cancer Refractory anemia (clinical) toxic encephalopathy acquired polycythemia vera facioscapulohumeral muscular dystrophy glioblastoma malignant glioma non-small cell lung carcinoma pancreatic ductal adenocarcinoma adrenal medulla cancer atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma secondary polycythemia benign neoplasm of adrenal gland erythropoietin polycythemia lung cancer myopathy
C, D	Pharos: Q16665	glioblastoma sclerosing cholangitis breast carcinoma hypertensive disorder astrocytic tumor esophageal squamous cell carcinoma hemangioblastoma primary biliary cholangitis Neoplasm Invasiveness thyroid adenoma hyperplasia childhood cerebral astrocytoma pilocytic astrocytoma primary sclerosing cholangitis lung disease glioblastoma sclerosing cholangitis breast carcinoma hypertensive disorder astrocytic tumor esophageal squamous cell carcinoma hemangioblastoma primary biliary cholangitis Neoplasm Invasiveness thyroid adenoma hyperplasia childhood cerebral astrocytoma pilocytic astrocytoma primary sclerosing cholangitis lung disease pulmonary hypertension ductal breast carcinoma in situ malignant pancreatic neoplasm gemistocytic astrocytoma idiopathic pulmonary fibrosis prostate cancer protoplasmic astrocytoma brain ischemia skin cancer fibrillary astrocytoma giant cell glioblastoma carcinoma subependymal giant cell astrocytoma thyroid gland carcinoma anaplastic astrocytoma juvenile pilocytic astrocytoma congestive heart failure sarcomatoid carcinoma skin neoplasm breast ductal adenocarcinoma gastric carcinoma heart failure oligodendroglioma amyotrophic lateral sclerosis ovarian disease kidney disease dermatomyositis diffuse astrocytoma major depressive disorder brain hypoxia - ischemia erythropoietin polycythemia small cell lung carcinoma familial polycythemia cancer spinal cord injury stomach disease cerebral astrocytoma thyroid cancer osteosarcoma cerebrovascular disorder ulcerative colitis pancreatic ductal adenocarcinoma colonic disease juvenile dermatomyositis congenital heart disease B-cell chronic lymphocytic leukemia bipolar disorder breast disease myopathy ovarian cancer cervical cancer undifferentiated carcinoma inborn carbohydrate metabolic disorder pancreatic neoplasm liver disease astrocytoma (excluding glioblastoma) prostate disease diabetes mellitus lymphatic system disease psoriasis Duchenne muscular dystrophy bone disease Emery-Dreifuss muscular dystrophy breast cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.