5LV2
Crystal structure of mouse CARM1 in complex with inhibitor LH1246
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
E | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
F | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
G | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
H | SCOP2B Superfamily | Arginine methyltransferase C-terminal oligomerisation domain-like | 8053426 | 3002184 | SCOP2B (2022-06-29) |
H | SCOP2B Superfamily | S-adenosyl-L-methionine-dependent methyltransferases | 8046583 | 3000118 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PRMT5_C_1 | e5lv2A1 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
A | PrmA | e5lv2A2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
B | PRMT5_C_1 | e5lv2B1 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
B | PrmA | e5lv2B2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
C | PRMT5_C_1 | e5lv2C2 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
C | PrmA | e5lv2C1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
D | PRMT5_C_1 | e5lv2D2 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
D | PrmA | e5lv2D1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
E | PRMT5_C_1 | e5lv2E1 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
E | PrmA | e5lv2E2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
F | PRMT5_C_1 | e5lv2F2 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
F | PrmA | e5lv2F1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
G | PRMT5_C_1 | e5lv2G1 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
G | PrmA | e5lv2G2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
H | PRMT5_C_1 | e5lv2H1 | A: beta sandwiches | X: Arginine methyltransferase oligomerization subdomain (From Topology) | H: Arginine methyltransferase oligomerization subdomain (From Topology) | T: Arginine methyltransferase oligomerization subdomain | F: PRMT5_C_1 | ECOD (1.6) |
H | PrmA | e5lv2H2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: S-adenosyl-L-methionine-dependent methyltransferases | F: PrmA | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF22528 | Arginine methyltransferase oligomerization subdomain (PRMT_C) | Arginine methyltransferase oligomerization subdomain | This entry represents a domain found C-terminal in protein arginine methyltransferases. This domain is involved in oligomerisation. | Domain | |
PF06325 | Ribosomal protein L11 methyltransferase (PrmA) (PrmA) | Ribosomal protein L11 methyltransferase (PrmA) | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR020989 | Histone-arginine methyltransferase CARM1, N-terminal | Domain | |
IPR011993 | PH-like domain superfamily | Homologous Superfamily | |
IPR025799 | Protein arginine N-methyltransferase | Family | |
IPR029063 | S-adenosyl-L-methionine-dependent methyltransferase superfamily | Homologous Superfamily |